I-Nicotinamide riboside chloride (NR-CL) (23111-00-4)

Matshi 11, 2020
SKU: 129938-20-1
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Nicotinamide riboside (NR) yi-nicotinamide entsha ye-nicotinamide adenine dinucleotide (NAD +) eyandulelayo. I …………….


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

Ividiyo yeNicotinamide riboside chloride (NR-CL) (23111-00-4) ividiyo

I-Nicotinamide riboside chloride (NR-CL) (23111-00-4) Suqobo

Igama lemveliso I-Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Igama leKhemikhali I-NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; I-Nicotinamide ribose chloride; I-3-Carbamoyl-1- (β-D-ribofuranosyl) i-pyridinium chloride; I-3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) i-pyridin-1-ium chloride; INicotinamide BD Riboside Chloride (WX900111); I-NR-CL;
Inani leCAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
I-Molecular Formula C11H15ClN2O5
Isisindo somzimba 290.7002
IMasaisotopic Mass 290.066949 g / mol
Indawo yokunyibilika N / A
umbala mhlophe
Sitempile yetanki -20 ° C Ifreezer
isicelo izongezo zokutya, intsimi yamayeza

Yintoni i I-Nicotinamide riboside chloride(NR-CL)?

I-Nicotinamide riboside (NR) yi-nicotinamide adenine dinucleotide entsha (NAD +) eyandulelayo. Uhlobo lwekristali ye-NR chloride ibizwa ngokuba yi-NIAGEN, eyindlela yokwenza i-nicotinamide riboside kunye nomthombo apho i-nicotinamide ngohlobo lwe-nicotinic acid inokufumaneka kwi-bioavava kwaye igqalwa njengekhuselekileyo (GRAS). I-chloride ye-NR ingumxholo wezaziso ezitsha zokutya, ezisetyenziswa ikakhulu kwizongezelelo zokutya.

INicotinamide Riboside Chloride sisithako sendalo esifunyanwa kubisi. Ngokwenene inxulumene ne-niacin kunye nezinye iintlobo zevithamini B3. Olunye uphando lufumanise ukuba iNicotinamide Riboside Chloride ineempawu ezizezinye ezinokuphucula imetabolism yokunceda ukutshisa iikhalori ezingaphezulu kunye nokukhusela ubunzima. Ukongeza ukunciphisa umzimba, iyanceda ukwandisa ukusebenza kwemisipha, ukwandisa inkcitho yamandla, kunye nokucutha umngcipheko wesifo seswekile.

Kwakhona, uphando ebantwini lubonise ukuba zozibini ezi ziNicotinamide Riboside Chloride ziphakamisa amanqanaba eNAD +, ezinceda ukuphucula iimeko ezinxulumene nobudala, nangona kusekutsha kakhulu ukwazi ukuba ziya kusebenza njani.

iinzuzo I-Nicotinamide riboside chloride(NR-CL)

I-Nicotinamide riboside chloride yindlela yokwenza i-nicotinamide riboside, izibonelelo zayo / ukusebenza kuyafana ne-nicotinamide riboside. Ukuthatha inxaxheba kwi-metabolism emzimbeni, kunokusetyenziselwa ukukhusela isifo se-pellagra okanye esinye isifo sokukhubazeka kwe-niacin kunye nokunciphisa i-cholesterol kunye ne-triglycerides egazini. Isetyenziselwa ukwehlisa umngcipheko wokuhlaselwa sisifo sentliziyo kubantu abane cholesterol ephezulu esele banesifo sentliziyo. Ngamanye amaxesha isetyenziselwa ukunyanga isifo se-coronary artery isifo (isifo sokuqina kwemithambo yegazi), ukukhusela ingqondo kunye nesibindi (isifo sentliziyo, isifo seswekile, isifo se-Alzheimer's).

Ngaphandle koko, iNicotinamide riboside chloride inezinye izibonelelo ebantwini:

  • Ukugaya ukutya ngokuchanekileyo kunye nokufunxa kweeprotheni kunye namafutha;
  • Siza ukuguqula i-amino acid tryptophan ebalulekileyo kwi-niacin;
  • Ukunciphisa ukugabha, kunye nokunciphisa iziphumo zokuthatha ii-antidepressant ngenxa yomlomo owomileyo kunye nobunzima bokuchama;
  • Ukukhuthaza i-nucleic acid synthesis kunye nokukhusela ukwaluphala kwezicubu namalungu, ngaloo ndlela ufezekisa injongo yokulibazisa ukuguga;
  • Ukuhamba kancinci kwemisipha yokuhamba kancinci, ukukhubazeka kwethambo kunye nesandla kunye nonyawo;
  • Unyango lwe-hypometabolism ye-kuzaliwa kunye nokunyusa amandla imetabolism;
  • Uthintelo kunye nonyango lokunqongophala kweevithamini B6;
  • Unyango lwe-carpal tunnel syndrome;
  • Inceda ukunciphisa umzimba kunye nokuqinisa ukusebenza kwemisipha.
  • Ukuphucula ukumelana komzimba kwiiseli zomhlaza
  • Thintela ukulahleka kwendlebe
  • Ngaba yindalo yendalo.
  • Ukuthatha imithamo emikhulu kunokuphelisa ukulutha kweziyobisi kwaye ube nesiphumo esihle sokudanjiswa.
  • Ukuphucula ukusebenza kweeseli ze-epidermal, kunye nemisebenzi yezinye iiseli emzimbeni womntu, ukugcina ulusu luvutha.

I-Nicotinamide riboside chloride(NR-CL) Ukusetyenziswa

Kuba iNicotinamide riboside chloride ineepropathi zamayeza eziluncedo, ihlala isetyenziswa kwizongezo zokutya, amayeza kunye nensimu yokutya.

Imbekiselo:

  • Conze D, Brenner C, Kruger CL. Ezokhuseleko kunye neMetabolism yoLawulo lwexesha elide lwe-NIAGEN (Nicotinamide Riboside Chloride) Kwindawo ekungekho si sifo kuyo, uLwazi oluphinda kabini, uLawulo lweKlinikhi oluLawulwa ngabadala abaDala. I-Sci Rep. I-2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. I-PMID: 31278280 PMCID: PMC6611812.
  • UBogan, KL, uBrenner, uC. (2008). "I-Nicotinic acid, i-nicotinamide, kunye ne-nicotinamide riboside: Uvavanyo lweemolekyuli zeevithamini ze-NAD + zangaphambili kwizondlo zabantu". Annu. Umfundisi Nutr. 28: 115–130. doi: 10.1146 / annurev.nutr.28.061807.155443. I-PMID 18429699.
  • I-Chi Y, i-Sauve AA (Novemba 2013). "I-Nicotinamide riboside, isakhamzimba sokutya, iyivithamini B3 eneziphumo kwimetabolism yamandla kunye ne-neuroprotection". I-Curr Opin Clin Nutr Metab yoKhathalelo. 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. I-PMID 24071780.