+ 86 (1812) 4514114 info@phcoker.com

I-Raw Flibanserin HCL powder (147359-76-0)

I-Raw Flibanserin hydrochloride powder, ethengiswa phantsi kwegama le-Addyi, igama lonyango elivunywe ukuba lonyango ... ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1250kg / inyanga

inkcazelo

Ividiyo yeRF Flibanserin HCL (147359-76-0)

I-Raw Flibanserin HCL powder (147359-76-0) Suqobo

Igama lemveliso Flibanserin hydrochloride powder
Igama leKhemikhali UNII-96XTC36K1B, 96XTC36K1B
uhlobo Numama Addyi
Iqela leziyobisi I-Serotonin antiagonist (MSAA)
Inani leCAS 147359-76-0
InChIKey XGAGFLQFMFCIHZ-UHFFFAOYSA-N
I molecular Fi-ormula C20H22ClF3N4O
I molecular WSibhozo 426.8630896
IMasaisotopic Mass 426.143 g / mol
Ukuxuba Point > 225 ° C (i-dec.)
Fukuhlaziywa kwakhona Point Akukho mhla okhoyo
I-Biological Half-Life iiyure 11
umbala OMhlophe
Sukufaneleka I-DMSO (Kancinci), i-Methanol (Kancinci)
Sisibetho Tukushisa Ukushisa kwamagumbi
Aukuguquka Kuphuhliswe ukuba unyango lweengxaki zobunqweno obunqwenelekayo ngokwesini kubasetyhini.

I-Raw Flibanserin HCL powder (147359-76-0) Inkcazo

I-Flibanserin hydrochloride yilezi zixhobo zokuqala eziza kuvunyelwa ukugula ngengxaki yesondo (HSDD) kwi-women's premenopausal kwi-FDA ngo-Agasti 2015. Kwakusungulwa okokuqala njengemithi yokuxhatshazwa yi-Boehringer Ingelheim, kodwa yabonisa ukungabi nanobuchule kwizilingo kwaye yaqhutyiswa phambili njengengxaki yesifo sobisi ngokwesini se-Sprout Pharmaceuticals. Indlela yokusebenza kaFlibanserin ibangelwa ukuxhamla kwayo ephezulu ye-5-HTA1 kunye ne-5-HTA2, i-5-HTA1 kunye nomchasi kwi-5-HTA2, okubangelwa ukunciphisa i-serotonin ebuchosheni kunye nomphumo wokwandisa i-norepinephrine kunye ne-dopamine neurotransmitters.

I-Flibanserin hydrochloride powder (147359-76-0) Indlela yokuSebenza

I-Flibanserin hydrochloride isebenza kwiikhemikhali ezintathu zobuchopho ezibalulekileyo: i-dopamine, i-norepinephrin, kunye ne-serotonin. Ezi khemikhali ziyi-neurotransmitters. Banoxanduva lokuthumela iimpawu phakathi kwengqondo kunye nezinye iinxalenye zomzimba ngokusebenzisa inkqubo ye-nervous.

I-Dopamine kunye ne-norepinephrin ibandakanyeka kwixabiso lesondo. Nangona kunjalo, i-serotonin inegalelo ekukhuselweni ngokwesondo kwaye inokunciphisa isondo. Kucingelwa ukuba ukuba le michiza ayinakulinganisela - ukuba i-dopamine kunye ne-norepinephrine amanqanaba aphantsi kakhulu kwaye / okanye amazinga e-serotonin aphakamileyo kakhulu-umfazi unokuziva unqwenela umnqweno wesini.

I-Flibanserin hydrochloride isebenza ngokuphakamisa amanqanaba e-dopamine kunye ne-norepinephrin ngelixa ihlalisa amanqanaba e-serotonin. Ngale ndlela, iikhemikhali ezikunceda ukukhuthaza umnqweno wesondo zonyuka kwaye enye inokukunqanda umnqweno iyancipha.

Ukusetyenziswa kwe-Raw Flibanserin HCL powder (147359-76-0)

I-Flibanserin hydrochloride yi-5-HT1A i-agonist kunye ne-5-HT2A inxamnye nayo eyenziwa ukunyangwa kwengxaki yokunyaniseka ngokwesini kunye nabesifazane (1,2).

Ukuphakanyiswa kwe-Raw Flibanserin HCL powder (147359-76-0) Isisombululo

100 mg ngomlomo ngenye imini ngexesha lokulala

Ubude bonyango: Eli liza kufuneka liyeke emva kweeveki ze-8 ukuba isiguli asibibi ukuphucula iimpawu.

Iingxelo: Eli chiza alibonakalwanga ukuphucula ukusebenza kwezesondo, kwaye alubonakalwanga kunyango kuma-postmenopausal abesifazane okanye kumadoda.

Imiphumo emibi yeFlibanserin hydrochloride powder (147359-76-0)

Iziganeko ezimbi ziqhelekileyo phakathi kwabasetyhini abathatha i-flibanserin. Uninzi lweziganeko ezimbi zazingenangqondo ukuya kumodareyitha. Iziganeko ezichasiweyo eziqhelekileyo ziquka ukungcola, isisongela, ukuziva ude, ukulala, kunye neengxaki zokulala.

Ukusela utywala ngelixa i-flibanserin ingakhokelela ekubeni uxinzelelo oluphantsi lwegazi (uxinzelelo oluphantsi lwegazi oluvelisa iimpawu emva kweglasi ze-2 zewayini zenzeka kwi-17%).


=

I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

Qhagamshelana nathi