I-Oleoylethanolamide (OEA) (111-58-0)

Matshi 11, 2020
SKU: 16589-24-5
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Oleoylethanolamide (OEA) yi-endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Yi……..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

I-Oleoylethanolamide (OEA) (111-58-0) ividiyo

I-Oleoylethanolamide (OEA) (111-58-0) Iinkcukacha

Igama lemveliso I-Oleoylethanolamide (OEA) umgubo
Igama leKhemikhali n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

I-N-oleoyl ethanolamine; i-Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Inani leCAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
I-Molecular Formula C20H39NO2
Isisindo somzimba 325.5 g / mol
IMasaisotopic Mass 325.537 g · mol-1
Indawo yokunyibilika I-59-60 ° C (138-140 ° F; 332-333 K)
Point yo kubilisa 496.4 ± 38.0 ° C (Kuxelwe kwangaphambili)
mninzi 0.915 0.06 3 g / cmXNUMX (Kuxelwe kwangaphambili)
umbala Powder
Sitempile yetanki -20 ° C
Ukunyibilika kwi-ethanol kunye ne-DMSO I-Soluble
isicelo Indawo yePhamaceutical; izinto ezongeziweyo

isishwankathelo

I-Oleoylethanolamide (OEA) okanye i-N-Oleoylethanolamide (OEA) sisimolekyuli esiveliswa emzimbeni, esidla ngokufumaneka emathunjini. Ubungqina obongezayo bicebisa ukuba i-OEA inokuthi isebenze njenge-endo native neuroprotective factor kwaye ithathe inxaxheba kulawulo lwezinto ezinxulumene nokuziphatha. Kwakhona, ichazwe njenge-arhente esebenza ngokungapheliyo ekwehlisa ukutya kunye nokufumana umzimba.

Yintoni iOleoylethanolamide (OEA)?

I-Oleoylethanolamide (OEA) yi-endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Yenzeka ngokwendalo i-glycolamide lipid eneempawu ezizodwa zasekhaya ezifana nokulawulwa komnqweno wokutya, imisebenzi yokuchasana nomhlaza, ukukhuthaza i-lipolysis kunye ne-acid oxidation. I-Oleoylethanolamide inokuthathwa njengehomoni ye-amathumbu yobuchopho bamathumbu. I-Oatmeal, amandongomane, kunye nomgubo wecocoa zizinto eziphambili zokutya kwiOleoylethanolamide ekutyeni. Nangona kunjalo, isixa se-Oleoylethanolamide esifunyenwe kwezi zinto zokutya siphantsi (sangaphantsi kwe-2 µg / g).

Njengomntu osebenzayo kwi-lipid medium, i-oleylethanolamide (i-OEA) iveliswa emathunjini kunye nezinye izicubu, kwaye ibandakanyeka kummiselo wamandla ohlobo lwe-mammalian, ukulawula ukutya kunye nemetabolism ye-lipid, njengokulawula ukutya kweVertebrate kunye nobunzima bomzimba. I-Oleoylethanolamide yi-fatty acid ethanolamide (i-FAE), i-analog ye-monounsaturated ye-endocannabinoid arachidonic acid ethanolamide (anandamide), kunye nomchaphazeli osebenzayo weanamamide. Kuya kufuneka ukuba uqaphele ukuba i-Oleoylethanolamide yahlukile kwi-anandamide, izimeleyo kwi-cannabinoid receptor, kwaye ikhuphe umsebenzi wayo webhayoloji ngenye indlela, ilawula umsebenzi we-PPAR-α ukukhuthaza i-lipolysis. I-Oleoylethanolamide ichiza elinokubakho kwaye likhuseleke ngokuchasene nokukhuluphala elingena endaweni ye-CB1 antagonism.

Izifundo zangaphambi kwexesha zibonise ukuba i-Oleoylethanolamide ikwayinto esebenzayo yokuthintela ukuvuvukala kunye ne-antioxidant ekhupha iziphumo ze-neuroprotective kubusela. Ulawulo lwe-Exo zemvelo lwe-Oleoylethanolamide lunokuthintela ngokufanelekileyo i-TLR4-mediated proinfigueatory cascades-ke oko kunciphisa ukukhutshwa kwee-cytokines zeproinokhem kunye neekhemokhines, uxinzelelo lwe-oxidative kunye ne-nitrosative, kwaye ekugqibeleni kuthintele ukonakala kwemithambo kumqolo osecaleni weentonga.

Imithombo ye-Oleoylethanolamide (OEA)

Kukho imithombo emibini yokufumana i-Oleoylethanolamide (OEA), enye isuka kwizityalo zendalo, kwaye enye yenziwa ngokufanelekileyo elebhu.

I-Achyranthes Aspera, yemveli e-India, China nakwamanye amazwe ase-Asia, kuthiwa iqulethe i-Oleoylethanolamide OEA. Ingxaki ye-Oleoylethanolamide yendalo-eluhlaza kukuba ikho indawo ekhutshiwe kuphela, u-15: 1 yinto edumileyo, kwaye ayisiyongozi njengoko abathengi okanye abavelisi abalongezayo belindele. Ewe kunjalo, inokuba ngaphezulu, kodwa iindleko ziya kuba phezulu kakhulu, ke ngoko ayisiyongozi kangako ukwenza i-Oleoylethanolamide OEA yendalo ngobuninzi.

Owona mthombo uphambili we-Oleoylethanolamide wenziwe kwi-oleic acid, wakhonza njengomanduleli weN-oleoyl-phosphatidylethanolamine, emva koko ucacisiwe yi-N-acyl-phosphatidylethanolamine-ukhetha phospholipase D (PLD) ukukhupha i-Oleoylethanolamide OEA.

I-Oleoylethanolamide yi-metabolite yendalo ye-oleic acid. Ke ngoko, ukutya okuchasene ne-oleic acid ngumthombo ngqo we-OEA.

Isebenza njani i-Oleoylethanolamide (OEA)?

Kubantu abatyebileyo, i-OEA inokulawula amandla e-homeostasis kunye nomnqweno wokutya ikakhulu ngokwenza ii-receptor ezahlukeneyo kubandakanya i-proximal proliferator-activated receptor-α (PPAR-α), i-receptor ye-G-protein-edityanisiweyo ye-receptor 119 (GPR119) kunye ne-receptor ye-treptor enokwenzeka ye-cation (TRPV1). Ewe, i-OEA ivuselela ezi receptors kunye nokulibaziseka kokuqala kokutya, ukunciphisa ubungakanani bokutya, ukunciphisa izithuba phakathi kokutya kwaye ekugqibeleni kumodareyithe ubunzima bomzimba.

Ngaphezu koko, ezinye iimvavanyo zokuvavanywa zibonisa ukuba i-OEA ikwacinezela ukubonakaliswa kwe-IL-6, i-interleukin-8 (IL-8), i-molecule-1 ye-ICEL-kunye ne-cell cell adhesion molecule-1 (VCAM-1) kwi-TNF -Into ebangelwa kukuvuvukala kwiiseli zomntu eziphakathi kweeseli zomzimba ngokusebenzisa amandla ezixhobo ezamkela ukuvuvukala. I-OEA ikwathintele indlela yenyukiliya-B (NF-kB) indlela yomzimba. Kwisaveyi ye-YT et al, i-OEA (1 µmol / L) ithintele i-TNF-α incence VCAM-50 expression in HUVEC.

Izibonelelo zeOleoylethanolamide (OEA)

I-Oleoylethanolamide (i-OEA) i-powder ilungile ukunciphisa umzimba njengommiselo wokutya kunye nokuxhasa amanqanaba e-cholesterol esempilweni kubantu abadala.

I-Oleoylethanolamide (OEA) njengendawo yokucinezela yokutya

Ukucinezela ukuthanda ukutya kwaye ngaloo ndlela kunciphise ukutya kakhulu kuyindlela efanelekileyo yokulawula ukulinganisela kwamandla kunye nobunzima bomzimba. Ukusukela inkanuko yokutya kungoyena ndoqo wokulawula amandla (ukutya) ukutya, ukulawula ukuthanda ukutya kubalulekile ekulawuleni ubunzima bomzimba, ngakumbi xa kudityaniswa nokukhethwa kwendlela yokuziphatha ebandakanya ukujongisisa ukutya, ukongeza ukutya kunye nokuzivocavoca.

Isongezelelo se-Oleoylethanolamide sinceda ukulawula imetabolism ye-lipid, inceda ukulawula indlala ngokuthumela imiyalezo engakumbi yokutya kwingqondo kwaye ibonakalisiwe ukunceda ukunciphisa kokubini amanqanaba e-triglyceride kunye ne-cholesterol yegazi.

I-Oleoylethanolamide yolawulo lwamafutha oMzimba

I-OEA yindlela ekhuselekileyo yecala lokulawula ukuthanda ukutya kunye nenkcitho yamandla.

Iziphumo ze-OEA zafundwa okokuqala kuba zabelana ngokufanayo nangenye ikhemikhali, i-cannabinoid eyaziwa ngokuba yi-anandamide. I-Cannabinoids inxulumene nesityalo i-Cannabis, kwaye i-anandamides ekhoyo kwisityalo (kunye nentsangu) inokunyusa umnqweno womntu wokufunxa ngokuvuselela impendulo yokondla. Ngokutsho kwe-Wikipedia, i-Oleoylethanolamide yi-analogue ye-monounsaturated ye-endocannabinoid anandamide. Nangona i-OEA inesakhelo seekhemikhali esifana ne-anandamide, iziphumo zaso ekutyeni nakulawulo lwesisindo zahlukile. Ngokungafani ne-anandamide, i-OEA isebenza ngokuzimela kwindlela ye-cannabinoid, elawula umsebenzi we-PPAR-α ukukhuthaza i-lipolysis.

Oleoylethanolamide ukwakha umzimba

Wonke umntu ufuna impilo ngokwakha umzimba. I-OEA iya ithandwa kakhulu ngabakhi bomzimba. Kwimimandla yokuncedisa ekwakheni umzimba, i-TTA (i-tetradecylthioacetic acid) ihlala isetyenziswa ngokudibeneyo nge-oleoylethanolamide (OEA), zombini ezi zinto zikwanceda ukutshisa amanqatha kunye nokunciphisa indlala. I-TTA inokuba ikwathembisa kakhulu phakathi kwezongezo zokulwa namafutha, kuba kubonakala ngathi kutshisa amanqatha azimeleyo emthambo; Iziphumo zokuqala zibonisa ukuba umzimba ubonakala "ususa" amanqatha ngokwawo kunokuba ufune ukutshiswa ngumzimba.

I-Oleoylethanolamide (OEA) iyanciphisa i-triglycerides kunye ne-cholesterol, kwaye, xa idityaniswa ne-cannabinoid antagonist, ivimba ukuzuza komzimba kwaye iphucule i-dyslipidaemia kwiimodeli zezilwanyana zokukhuluphala.

Ukongeza, inkqubo yolawulo ye-oleoylethanolamide ifunyenwe ukuba iguqule i-glucose homeostasis, kunye nokukhululwa kwe-insulin kunye nokusayina kwe-insulin kuzo zombini ii-hepatocytes kunye ne-adipocytes.

Olunye ubuyiselo lubonisa ukuba i-oleoylethanolamide isongezelelo inefuthe elihle kuxhala, kwaye ngakumbi umkhondo kunye nobungqina ziyafuneka ukuxhasa.

Uyisebenzisa kanjani i-Oleoylethanolamide OEA

Oiziphumo ze-leoylethanolamide

I-Oleoylethanolamide i-OEA intsha kakhulu kwimarike yokungezelela, kwaye akukho miphumo mibi imbi iye yanikwa. I-US Food and Drug Administration (FDA) yayingenazinkxalabo malunga nokhuseleko lwe-OEA. Kubomi bemihla ngemihla, i-oleoylethanolamide iyindlela ekhuselekileyo yokulahleka kwesisindo, esetyenziselwa ukuvavanya ubungakanani be-catabolism kwindawo ye-gastro-emathunjini, ukunceda ukunciphisa amanqatha ngaphandle kwemiphumo emibi engathandekiyo.

Oleoylethanolamide umyinge

Akukho dosi yaphakanyiswa esidlangalaleni ye-oleoylethanolamide kuba izongezo ze-oleoylethanolamide azikathandwa kangako kwaye kwinqanaba lokuqala. I-RiduZone yayingumgubo wokuqala we-OEA ukuphawulwa ngo-2015.

Isithamo sedosi ye-oleoylethanolamide yecephe enye eyi-200mg xa ithathwe ngaphandle kwendibaniselwano

Uphando lubonisa ukuba unokuthoba okanye unyuse imithamo yemihla ngemihla ngokwamanqanaba omzimba.

I-100mg yomntu ongu-150lb

I-145mg yomntu ongu-200lb

I-180mg yomntu ongu-250lb

Ukusetyenziswa kweOleoylethanolamide (OEA)

I-Oleoylethanolamide powder isebenzise isibonelelo sezeMpilo, esenziwe kwi-Hard capsule okanye kwi-tablet yokulahleka kwesisindo.

Imbekiselo:

  • UGaetani S, u-Oveisi F, uPiomelli D (2003). Uguquko lwepatheni yokutya kumgangatho ngumlamli we-anorexic lipid oleoylethanolamine ”. I-Neuropsychopharmacology. 28 (7): 1311-6. Doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, uPiomelli D (2005). "Ukulawulwa kokutya okwenziwe yi-oleoylethanolamine". Iseli. Imol. Inzululwazi yoBomi. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. I-PMID 15770421.

  • UGiuseppe Astarita; UBryan C. Rourke; UJohnie B. Andersen; UJin Fu; UJanet H. Kim; UAlbert F. Bennett; UJames W. Hick kunye noDaniel Piomelli (2005-12-22). "Ukonyuka kokunyuswa kwe-oleoylethanolamine ukugaya esiswini esincinci seBurmese python (Python molurus)". Ngaba iJ Physiol Regul Dibanisa Umzimba oHlanganisiweyo weKhompiyutha. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. I-PMID 16373434.

  • UGaetani S, Kaye WH, Cuomo V, uPiomelli D (Septemba 2008). Indima ye-endocannabinoids kunye nemizobo yabo kwi-obesity kunye nengxaki yokutya ". Yitya ubunzima beLight. 13 (3): e42-8. I-PMID 19011363.

  • USerrano A, et al. I-Oleoylethanolamide: Iziphumo zokuhanjiswa kwe-hypothalamic kunye neeputternides ezilawula ukutya. I-Neuropharmacology. (2011)