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I-Raw Flibanserin powder (167933-07-5)

I-Raw Flibanserin powder iyinkunkuma yesigqirha esiboniswe ukunyanga kwabasetyhini base-foremenopausal abanokufumana isondo soxhatshazo oluqhelekileyo ....


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1489kg / inyanga

inkcazelo

I-Raw Flibanserin powder (167933-07-5) ividiyo

I-Raw Flibanserin powder (167933-07-5)

I-Raw Flibanserin powder, ethengiswa phantsi kwegama le-Addyi, igama le-serotonin agonist kunye nomchasi osebenzayo kunyango lwabasetyhini ababengaphambi kwe-menopausal ne-hyposicactive disorder disorder (HSDD). Amachiza akwandisa inani lokunelisa iziganeko zesondo ngenyanga nganye malunga nesiqingatha se-placebo ukusuka kwindawo yokuqala ukusuka malunga ezimbini ukuya kweyesithathu. Ngexesha elifanayo, Inendima njenge-agonist ye-serotonergic, isifo se-serotonergic kunye ne-antidepressant ..

I-Raw Flibanserin powder (167933-07-5) Suqobo

Igama lemveliso I-Raw Flibanserin powder
Igama leKhemikhali 1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one
uhlobo Numama Addyi
Iqela leziyobisi I-serotonin agonist ne-antagonist ezininzi
Inani leCAS 167933-07-5
InChIKey I-PPRRDFIXUUSXRA-UHFFFAOYSA-N
I molecular Fi-ormula C20H21F3N4O
I molecular WSibhozo 390.41 g / mol
IMasaisotopic Mass 390.167 g / mol
Ukuxuba Point 225 ° C
Point yo kubilisa N / A
I-Biological Half-Life ~ Ii11 iiyure
umbala Mhlophe ukuba zibophe
Sukufaneleka I-DMSO: i-soluble10mg / mL, icacile
Sisibetho Tukushisa 2-8 ° C
I-Raw Flibanserin powder Aukuguquka Kuphuhliswe ukuba unyango lweengxaki zobunqweno obunqwenelekayo ngokwesini kubasetyhini

I-Raw Flibanserin powder (167933-07-5) Inkcazo

I-Flibanserin powder yiyobisi yokuqala ekuvunyelwene ngayo ingxaki yokuziphatha ngokwesondo (HSDD) kwi-women-premenopausal nge-FDA ngo-Agasti 2015. Kwakusungulwa okokuqala njengemithi yokuxhatshazwa yi-Boehringer Ingelheim, kodwa yabonisa ukungabi nanobuchule kwizilingo kwaye yaqhutyiswa phambili njengengxaki yesifo sobisi ngokwesini se-Sprout Pharmaceuticals. Indlela yokusebenza kaFlibanserin ibangelwa ukuxhamla kwayo ephezulu ye-5-HTA1 kunye ne-5-HTA2, i-5-HTA1 kunye nomchasi kwi-5-HTA2, okubangelwa ukunciphisa i-serotonin ebuchosheni kunye nomphumo wokwandisa i-norepinephrine kunye ne-dopamine neurotransmitters.

I-Flibanserin powder (167933-07-5) Indlela yokuSebenza

Indlela yokusebenza kaFlibanserin ibangelwa ukuxhamla kwayo ephezulu ye-5-HTA1 kunye ne-5-HTA2, i-5-HTA1 kunye nomchasi kwi-5-HTA2, okubangelwa ukunciphisa i-serotonin ebuchosheni kunye nomphumo wokwandisa i-norepinephrine kunye ne-dopamine neurotransmitters. UFlibansetrin unamabutho aphezulu okufumana i-serotonin receptors engqondweni: isebenza njenge-agonist kwi-5-HT1A kunye nomchasi kwi-5-HT2A. Ku-vivo, i-flibanserin ibopha ngokulinganayo kwi-5-HT1A kunye ne-5-HT2A i-receptors. Nangona kunjalo, phantsi kwamanqanaba aphezulu eengqondo ze-5-HT (oko kukuthi, phantsi kwengcinezelo), i-flibanserin inokuhlala i-5-HT2A i-receptors kwinani eliphezulu kune-5-HT (1A) receptors. Inokuthi ixhomekeke ngokulinganayo i-D4 (dopamine) receptors kunye ne-5-HT2B kunye ne-5-HTB2C. Isenzo salo kwi-receptors ye-neurotransmitter sinokubangela ukunciphisa amanqanaba e-serotonin kunye nokwandisa kwi-dopamine kunye namazinga e-norepinephrine, onke awo angadlala indima ekusebenziseni umvuzo. I-Flibanserin ithengiswa phantsi kwegama le-Addyi igama lorhweba kwaye liboniswe ukonyango lwabasetyhini be-premenopausal abanokufumana ingxaki yokuzibandakanya ngokwesini (i-HSDD) ngokubanzi, njengento ebonakaliswa ngumnqweno wesini ophantsi owenza ukuba kunzima ukuphazamiseka.

Ukusetyenziswa kweFlibanserin powder (167933-07-5)

I-Flibanserin powder yi-5-HT1A i-agonist kunye ne-5-HT2A umphikisi ophuhliswayo kunyango lweengxaki zesini esingazenzisiyo kwizesetyhini (1,2).

Ukuphakanyiswa kweFlibanserin powder (167933-07-5) Isisombululo

100 mg ngomlomo ngenye imini ngexesha lokulala

Ubude bonyango: Eli liza kufuneka liyeke emva kweeveki ze-8 ukuba isiguli asibibi ukuphucula iimpawu.

Iingxelo: Eli chiza alibonakalwanga ukuphucula ukusebenza kwezesondo, kwaye alubonakalwanga kunyango kuma-postmenopausal abesifazane okanye kumadoda.

Imiphumo emibi yeFlibanserin powder (167933-07-5)

Iziganeko ezimbi ziqhelekileyo phakathi kwabasetyhini bathabatha ipilbanserin powder. Uninzi lweziganeko ezimbi zazingenangqondo ukuya kumodareyitha. Iziganeko ezichasiweyo eziqhelekileyo ziquka ukungcola, isisongela, ukuziva ude, ukulala, kunye neengxaki zokulala.

Ukusela kotywala ngexesha i-flibanserin powder ingakhokelela ekubeni uxinzelelo oluphantsi lwegazi (uxinzelelo oluphantsi lwegazi oluvelisa iimpawu emva kweglasi ze-2 zewayini zenzeka kwi-17%).


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I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

Qhagamshelana nathi