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I-Raw Tadalafil ephosa (171596-29-5)

I-Raw Tadalafil powder phantsi kwegama leCialis isetyenziselwa ukunyanga ukungasebenzi kakuhle (impotence) kunye neempawu ze-benign Prostatic ………


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1190kg / inyanga

inkcazelo

Tadalafil powder video

Ulwazi loLwazi

Igama lemveliso Tadalafil powder
Igama leKhemikhali (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
uhlobo Numama Cialis, Adcirca
Iqela leziyobisi I-PAH, i-PDE-5 Inhibitors; I-Phosphodiesterase-5 Enzyme Inhibitors
Inani leCAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
I molecular Fi-ormula C22H19N3O4
I molecular WSibhozo 389.4
IMasaisotopic Mass 389.138 g / mol
Ukuxuba Point 298-300 ° C
Fukuhlaziywa kwakhona Point 2 ℃
I-Biological Half-Life iiyure 17.5
umbala Umhlophe ukuya kwi-Cyrstalline Solid Off-White
Sukufaneleka I-DMSO (78 mg / ml kwi-25 ° C), i-methanol, amanzi (<1 mg / ml kwi-25 ° C), i-dichloromethane, ne-ethanol (<1 mg / ml kwi-25 ° C)
Sisibetho Tukushisa Gcina kwiqondo lobushushu phakathi kwe-59 ° F kunye ne-86 ° F (15 ° C no-30 ° C). Musa ukugcina le mayeza kwiindawo ezinomanzi okanye ezinamanzi.
Tadalafil Aukuguquka Amaphilisi amadaka e-Tadalafil amancinci, i-candy yezocansi, ikhofi yesondo, njl.

inkcazelo

I-Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4 -N] I-Cialis), luhlobo lwe-PDE1,4 inhibitor kunye nesiyobisi esilawulwa ngomlomo. Sisiphumo esivela kwi-b-carboline kwaye sahlulwe ngokwe-vardenafil (i-Levitraw) kunye ne-sildenafil (Viagraw), zombini ezo zithintela i-PDE5 inhibitors esekwe kwisakheko esingumda frit pyrimidine. I-Tadalafil powder (i-CAS 5-171596-29) yandisa ukuphuma kwegazi kwi-corpus cavernosum ngokuphumla kwimisipha yemithambo yegazi, kwaye oku kwenza ukuba indoda ifezekise ukwakhiwa. I-Tadalafil powder ivunyiwe yi-United States (i-US) i-Food and Drug Administration (i-FDA) kwi-5 kunyango lwe-dysfunction (ED), kwaye yathengiswa kwihlabathi liphela phantsi kwegama lophawu lweCialis. Ikwasetyenziselwa ukunyanga uxinzelelo lwe-pulmonary arterial hyperplasia kunye ne-benign Prostatic hyperplasia, imeko apho ukwanda kwe-Prostate kuye kwandiswe, kubangela iingxaki ngokuchama.

Inxalenye ye-pharmacologic yeTadalafil yeyona nto ihlala isigxina (iiyure ze-17.5) xa kuthelekiswa ne-Viagra ne-Levitra (ii-4-5 iiyure). Esi siqingatha sobomi siphumela ixesha elide lokuthatha isenzo kwaye, ngokuyinxalenye, luxanduva lweSihenniso ye-Cialis "yepilisi yeveki." Esi siqingatha sobomi sisiseko sophando olusetyenziswayo lwe-tadalafil kwi-pulmonary arterial blood pressure unyango lwangomhla.

Indlela yokuSebenza

Ukulungiswa kwe-Penile ngexesha lokuvuselela ngokwesondo kuphunyezwe ngokuphumla kwemithambo ye-penile kunye ne-corpus cavernosal e-smooth muscles, ekhokelela ekunyuseni kwegazi kwi-organ. Olu luleko luvumela ukunyuka kwegazi kwiimitha ze-penile, ngelixa legazi lizalisa amagumbi amabini ngaphakathi kwipenisi ebizwa ngokuba yi-corpora cavernosa. Njengoko amagumbi agcwalisa igazi, ipenisi ikhula iqina. Ukulungiswa kuphelela xa isivumelwano somsila kunye negazi eliqokelelwayo liyakwazi ukuphuma ngeemvini ze-penile.

Le mpendulo iphakathi kukukhutshwa kwe-nitric oxide (NO) kwizitishi ze-nerve kunye neeseli ze-endothelial, ezivuselela ukudalwa kwe-cGMP kwiiseli zemisipha egudileyo kwaye ke zilawule ukudanjiswa kunye nokuthambeka kwemithambo yegazi ethwele igazi ukuya nokubuya kwilungu lobudoda. I-cyclic GMP ibangela ukuphumla kwemisipha egudileyo kunye nokonyuka kwegazi ukungena kwi-corpus cavernosum, kwaye ichaphazeleka luhlobo lwe-cGMP lwefosphodiesterase yohlobo lwe-5 (PDE5) kwindawo ye-corpus cavernosum ebekwe ecaleni kwempundu. I-Tadalafil inhibits ye-PDE5 kwaye ngaloo ndlela ikhulisa ngokwandisa inani le-cGMP ekhoyo. I-Tadalafil imisa i-PDE5 ekutshabalaliseni i-cGMP kwaye ke yonyusa i-cGMP ekhoyo yokufezekisa umsebenzi kwaye ibangela ukuba i-erection ihlale ixesha elide.

Nangona kunjalo, njengoko isiqingatha-sobomi seTadalafil sisifutshane, umphumo wayo ugqithisa kwixesha leentsuku ze-2 ukwenza i-PDE5 ubuye kwaye impilo yakho yesini-ibe nzima. Unokudinga ukuthatha ixesha elide ukuphumeza umphumo oyifunayo, njengezithuba eziphantsi ze-Cialis 4-5 iintsuku zeentsuku ze-4-5.

isicelo

  • I-Erectile i-dysfunction (ED)
  • I-pulmonary artertension
  • Benign prostatic hyperplasia
  • Uhlalutyo
  • I-Norepinephrine ithatha i-blocker
  • I-o-opiod receptor agonist

Ukuphakanyiswa kweTadalafil powder Isilinganisi

I-Cialis ivela kumacwecwe e-yellow, aphethwe ngamafilimu kunye nee-almond e-5, 10 kunye ne-20 milligram (mg). I-dose yokuqala ephakanyisiweyo ye-Cialis powder yokusetyenziswa njengoko kuyadingeka kwizigulane ezininzi i-10 mg, ithathwa ngaphambi kokusebenza komzimba wesondo.

I-dose yokuqala i-10 milligrams (mg) ubuncinane imizuzu eyi-30 ngaphambi komsebenzi wesondo. I dose inokunyuka ukuya kwi-20 mg okanye iyancipha kwi-5 mg, ngokusekelwe kumsebenzi ngamnye kunye nokunyamezela. Kodwa, ubuninzi be-20 mg njengomlinganiselo omnye. Umlinganiselo ophezulu ophakanyisiweyo we-dosing frequency unye ngosuku ngosuku ezininzi kwizigulane. akufanele ifune ukuthatha enye idosi kwiiyure ze-24. Izigulane ezilindele ukulalana ngesondo ubuncinane kabini ngeveki zingathatha umthamo wemihla ye-5 mg, kwaye oku kunokuncitshiswa ku-2.5 mg rhoqo ngosuku, kuxhomekeke kwisabelo ngasinye.

I-Cialis powder yokusetyenziswa njengoko kufuneka yaboniswa ukuphucula umsebenzi ngokuthelekiswa ne-placebo ukuya kwii-36 iiyure ezilandela i-dosing. Ke ngoko, xa ucebisa izigulana malunga nokusetyenziswa ngokufanelekileyo kweCialis powder, oku kufanele kuthathelwe ingqalelo.

Kubalulekile ukuba uqaphele ukuba ukwakhiwa akusayi kwenzeka ngokuthatha ipilisi. Kwaye musa ukuthatha i-Cialis yokungasebenzi kakuhle xa uthatha i-Adcirca ye-pulmonary arterial hypertension. Ngaphandle, i-Tadalafil yokungasebenzi kakuhle isetyenziselwa kuphela ngabantu abadala abaneminyaka eyi-18 nangaphezulu.

benefits

♦ I-tadalafil powder iyakunceda ukhulule umsizi kwi-prostate yakho kunye nesisu. Oku kunokukunceda ukuphucula iimpawu zakho ze-BPH.

♦ Ukuphucula iimpawu ze-ED, i-tadalafil powder inceda ukunyuka kwegazi kwi-penis. Oku kunokukunceda ufumane kwaye ugcine ukulungiswa. I-tadalafil powder ukukunceda ukuba unyuke, kufuneka uvuse ngesondo.

♦ Ku-PAH, i-tadalafil powder isebenza ukuphucula amandla akho okusebenzisa ngokukhupha imilambo yegazi emiphakeni yakho. Oku kwandisa ukuhamba kwegazi.

Imiphumela

Kanye kunye nemiphumo efunekayo, iyeza lingazenza ezinye iziphumo ezingafunekiyo. Nangona kungekhona zonke iziphumo zempembelelo ezinokuthi zenzeke, ukuba zenzeke zingadinga ukunikwa ngonyango. Nceda ukhangele iziphumo ezilandelayo zecala le-tadalafil:

Iziphumo eziqhelekileyo

▪ intloko

▪ uphazamise isisu

▪ intlungu

▪ imisipha yomzimba

▪ ukutshiza (isikhumba ebomvu)

▪ impumlo okanye iipumlo

▪ urhudo

Kuqhelekileyo kodwa iziphumo ezibi kakhulu

Ulungiso olude olunokubangela umonakalo kwi-penis, iingxaki zembono kunye nokulahlekelwa kwindlebe.

Ukuba ezi ziphumo zincinci, zingaphuma iintsuku ezimbalwa okanye iiveki ezimbalwa. Ukuba banzima kakhulu okanye bangahambi, xela ugqirha wakho okanye umkhompiki.

Abantu abaneemeko zilandelayo akufanele bathathe i-Cialis powder ngaphandle kokuba ugqirha uyavuma:

Iingxaki zengqondo zentliziyo, iingxaki ze-angina, okanye nayiphi na isifo sesifo

Uxinzelelo lwegazi oluphezulu okanye oluphantsi

Ukungaphumeleli kwentliziyo yesibhedlele okanye ukubetha phakathi kweenyanga ezidlulileyo ze-6, okanye i-myocardial infarction kwiinyanga ezidlulileyo ze-3

I-sickle cell anemia, i-myeloma, i-hemophilia, i-leukemia, okanye enye ingxaki yegazi

Isifo okanye isifo sesifo

Isisu sesisu

Retinitis pigmentosa

Ukukhubazeka kwesakhiwo sepenisi, njengesifo sikaPeyronie

Nayiphina imeko yempilo apho bacebiswe ukuba bangalalani ngesondo

Ukusebenzisana kweTadalafil

Xa usebenzisa i-tadalafil, kunokukho nezinye iziyobisi ezinokuchaphazela izidakamizwa, ezinokubangela kwimiphumo emibi. Ukusebenzisana kweziyobisi kunokutshintsha indlela amayeza akho asebenza ngayo okanye ukwandisa umngcipheko weemiphumo ezibi kakhulu.

I-Tadalafil inesiphumo esincinci se-synergistic ekunciphiseni i-nitrate ekunciphiseni kwegazi. I-Tadalafil inokubangela ukuphosa okukhulu kwi-blood pressure yakho xa kusetyenziswa i-nitrate, nto leyo ingakhokelela kwisisu, ukuphelelwa amandla, kunye nokuhlaselwa kwintliziyo. Ungasebenzisi i-tadalafil kunye naluphi na olu lulandelayo: ezinye iziyobisi ezisetyenziselwa ukuphatha intlungu yesifuba / i-angina (iititrate ezifana ne-nitroglycerin, isosorbide), iziyobisi zokuzonwabisa ezibizwa ngokuthi "i-poppers" eziqukethe i-amyl okanye i-nitrite.

Ukuba nawe uthatha i-alpha blocker yonyango (njenge doxazosin, tamsulosin) ukunyanga iprotate ye-prostate / i-BPH okanye uxinzelelo lwegazi oluphezulu, uxinzelelo lwegazi lungahle lube luphantsi kwaye lunokubangela ukuthotywa kwesisu okanye ukuphelelwa amandla. Ugqirha wakho angaqala unyango nge-dose ephantsi ye-tadalafil okanye utshintshe iyeza lakho le-alpha blocker ngamayeza ukunciphisa umngcipheko wexinzelelo lwegazi oluphantsi.

Kwizifundo zeklinikhi, amanani abalulekileyo okuphendula axelwa ukuya kwi-36 h emva kokungenisa iziyobisi. I-Tadalafil inyanzelwe ubukhulu becala kwisibindi yi-CYP3A4 kwizinto ezingasebenziyo ngokuchasene ne-PDE5 kwaye ikhutshelwe ikakhulu njengeemetabolites kulwelo kunye nomchamo. I-pharmacokinetics ye-tadalafil ayichaphazeleka zizinto ezinje ngokutya kunye notywala, ubudala, ubukho besifo seswekile, kunye nokungabikho ngokwaneleyo kwe-hepatic hepatic. Ezona ziganeko zixhaphakileyo ezinxulumene neziyobisi ziqaqanjelwa yintloko, iintlungu zangasemva, idyspepsia, kunye neMyggia. Kwi-doses ye-10 kunye ne-20 mg, i-Tadalafil ayinalo umphumo obonakalayo koxinzelelo lwegazi kunye nokubetha kwentliziyo kwaye ayikhangeli kwizimo zokonyuka kwe-myocardial infarction. Iingxelo ezinqabileyo zee-eension ezide ezingaphezulu kwe-4 h kunye ne-priapism ziye zaphawulwa ngokusetyenziswa kwe-tadalafil. Ukugxila, ukuba akuphathwanga kakuhle, kunokubangela ukonakala kwesithako. Izigulana ezine-erection engapheliyo kune-4 h ziyacetyiswa ukuba zifune unyango olungxamisekileyo. Kwizigulana ezinesifo seswekile, ukuphuculwa kokusebenza kwe-tadalafil kukukhetha uhlobo lweswekile kunye nohlobo lwesifo seswekile.

Amanye amayeza anokuchaphazela ukususwa kwe-tadalafil emzimbeni wakho, onokuchaphazela indlela i-tadalafil isebenza ngayo. Imizekelo ibandakanya i-azole antitifungals (njenge-itraconazole, i-ketoconazole), i-macrolide antibiotics (njenge-clarithromycin, i-erythromycin), i-HIV protease inhibitors (njenge-fosamprenavir, i-ritonavir), i-virus ye-hepatitis C inhibitors (njenge-boceprevir, telaprevir), i-rifampin, phakathi kwabanye .

Musa ukuthatha eli liyeza ngayo nayiphi na enye imveliso equkethe i-tadalafil okanye amanye amayeza afanayo asetyenziselwa ukunyanga ukungasebenzi kakuhle (i-dildfunction-ED okanye i-pulmonary hypertension (njenge sildenafil, vardenafil).

Ngokuphathelele ukusebenzisana kweTadalafil kunye nezinye iziyobisi zinezinto ezininzi, ukuba ufuna ukusebenzisa izidakamizwa kunye ne-tadalafil powder (CAS 171596-29-5), khumbula ukuqala ukudibana nogqirha wakho kwaye uyakukunika isiluleko esinobuchule kunye nolunokwethenjelwa.

Inkcukacha ezithe vetshe

I-tadalafil powder, i-sildenafil powder, kunye ne-vardenafil powder bonke benza ngokukhubaza i-enzyme ye-PDE5, kodwa ezi zi yobisi zivimbela i-PDE enzyme i-6, i-1 ne-11 ngee-degree. Ngokomzekelo, iSildenafil kunye ne-vardenafil inqanda i-PDE6, i-enzyme efumaneka kwiso, ngaphezu kwe-tadalafil. Abanye abasebenzisi be-sildenafil babona i-tinge bluish kwaye banokuvakalelwa okukhulu ekukhanyeni ngenxa ye-PDE6 inhibition. Ngaphandle koko, u-Sildenafil kunye ne-vardenafil banqanda i-PDE1 ngaphezu kwe-tadalafil. I-PDE1 ifumaneka kwingqondo, entliziyweni, kunye ne-muscular smooth muscle. Kucingelwa ukuba ukuvinjelwa kwe-PDE1 ngu-sildenafil kunye ne-vardenafil kukukhokelela ekutheni i-vasodilation, i-flushing, ne-tachycardia.

Xa kuthelekiswa nokusebenza kwi PDE6 kunye ne-PDE1, i-tadalafil yenza ngokugqithiseleyo kwi-PDE11. I-PDE11 ibonakaliswe kwisisu se-squelet, i-prostate, isibindi, iinjongo, i-pituitary gland, kunye nee-testes. Nangona kunjalo, iziphumo emzimbeni we-PDE11 azivimbelayo.


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Iziqulatho kunye nokuqulunqwa kwemveliso

Ucaphulo

  • I-1.Iziko leSizwe kwi-Biotechnology Information, e-US. ILayibrari kaZwelonke yamayeza, iTadalafil, iPaschem Iziqendu 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Ukusetyenziswa, Isisombululo, Iimpawu zecala leNkcukacha kunye naphi ukuthenga i-Generic Cialis (iTadalafil), iViagra (iSildenafil) kunye nezinye izidakamizwa ezigqithisileyo kwaye zikhuselekile kwi-intanethi, zipapashwe, 13 Dec 2017, iphepha 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: Uphatha i-Erectile Dysfunction, Izibonakaliso ze-Benign Prostatic Hyperplasia, kunye ne-Pulmonary Arterial Hypertension, i-CreateSpace Independent Publishing Platform, i-26 Mar 2015, iphepha 5-47.

I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

Qhagamshelana nathi