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I-Sodium (GM1) yengqondo yengulube (37758-47-7) i-Monosialotetrahexosylganglioside

I-GM1 powder isetshenziswe ngokubanzi ukuphatha ukulimala kweengqondo ze-hypoonic-ischemic brain, isifo se-Parkinson ...


Isimo: KwiMveliso yoLuntu
I-Synthesized and Customized Available
Amandla: 1277kg / inyanga

inkcazelo

I-sodium (GM1) yengqondo yengulube (37758-47-7) yevidiyo ye-Monosialotetrahexosylganglioside

I-Sodium (GM1) yengqondo yengulube (37758-47-7) Inkcazelo ye-sodium (GMXNUMX)

I-sodium (GM1-37758-47) ye-Sodium (GM7) yengqondo yengqondo yengqondo (1-XNUMX-XNUMX), igama elifutshane lingenziwa yi-GMXNUMX, ekhishwe kwingqondo yengulube kwaye ilungu le-gangliosides ye-gangliosides eline-resial acid acid.

I-GMl inokukhuthaza ukubuyiswa kwemisebenzi yengqondo emva kokulimala kwinkqubo yesistim ephakathi kwezinto ezihlukahlukeneyo, ukukhuthaza i-neuroplasticity. Iingcamango zibonisa ukulimala kweengqondo ze-GMl ze-brain, ubuchopho obubuhlungu bokubuyisela iiseliti zesigulane kumonakalo wentambo yomgudu kunomphumo wokukhusela kwaye kukhuthaza inxaxheba yeseli.

Isigaba sangaphambili sesigaba sesi-2 sesilingo sonyango sibonisa, sinokunciphisa i-nealtoxicity (OIN) ye-oxaliplatin. Kodwa ayizange iqinisekiswe isilingo sesigaba III. Uvavanyo lwesigaba III lufunekayo ukuphanda umphumo kunye nokukhuselwa kwe-sodium Injection ye-monosialotetrahexosylganglioside yokukhusela i-OIN kwisifo somhlaza.

I-sodium (GM1) yengqondo yengulube (37758-47-7) Specifications

Igama lemveliso I-Sodium (GM1) yengqondo yengqondo ye-Monosialotetrahexosylganglioside
Igama leKhemikhali I-sodium i-Monosialotetrahexosylganglioside (i-Porcine ingqondo)

Okanye i-GM1

Ukulandelelana /
uhlobo Numama Shenjie
Iqela leziyobisi Sphingolipids
Inani leCAS 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
I molecular Fi-ormula C73H134N4O31
I molecular WSibhozo 1563.85
IMasaisotopic Mass 1563.85
Ukuxuba Point N / A
I-Biological Half-Life /
umbala I powder ephilileyo engapheliyo
Umzimba i-chloroform / i-methanol (i-9: i-1): i-10 mg / mL, icacile, ingenambala
yoGcino Tukushisa -20 ° C
Aukuguquka Iimvume zokufumana i-toilin ye-k'holera eqokelela kwingqondo ekupheleni kwe-lipidosis.
Izinto zokuvavanya KwiNdlu Imigangatho yoLunga
Chauhlanga Umpu omhlophe okanye omhlophe; iyanuka, ayinambitha; emanzi. Le mveliso inqabile emanzini, ichithwe kakhulu kwi-methanol, phantse i-ethanol ene-anhydrous.
Uchonga
Umbala wokuphendula umbala 1 Thabatha isisombululo se-0.2ml phantsi kokuzimisela komxholo, engeza amanzi 2ml, uze wongeze isisombululo se-Hydroquinone hydrochloric acid (i-hydroquinone 0.2g, yongeza amanzi 10ml, yongeza i-hydrochloric acid 90ml, yongeza i-0.1mol / L I-sulfate isisombululo 0.25ml, i-friji Preservation) 2ml, Ukuhlambela ngamanzi okutshisa imizuzu ye-15, isisombululo esibhakabhaka kunye nemfusa, kunye ne-alcohol engeyiyo 5ml Ukukhutshwa kwe-vibration, ukungabi nendawo yokusela utywala.
Umbala wokuphendula umbala 2 Thatha le mveliso malunga ne-20mg, faka i-glacial acetic acid 1ml, ibhedi yamanzi ashushu atshisa ngokupheleleyo, udibanise ezintathu ze-chloride ukuhlolwa kwamanzi amanzi e-1, emanzini ashushu ajikelezayo kunye nodonga lombhobho ngokukhawuleza wongeza i-sulfuric acid 1ml, ukuze isisombululo sibe ngamacandelo amabini , i-interface-liquide yombane kufuneka ibe mnyama
Ityuwa Ukuchongwa kwe-sodium yetyuwa kule mveliso (i-Chinese Pharmacopoeia i-2015 edition ye-0301).
I-chromatography yamanzi (LC) Kwigrafu ye-chromatographic ebhalwe phantsi kokuzimisela kokuqukethwe, ixesha lokugcinwa kweyona nto ephambili yesisombululo sokuvavanya kufuneka ihambelane nexesha lokulondoloza kwinqanaba eliphambili lesisombululo sokulawula.
Ukutshatyalaliswa kwemiboniso Imephu yokuqhawula ukukhanya kwe-infrared yile mveliso kufuneka ihambelane nemephu yolawulo lwemveliso (i-Chinese Pharmacopoeia 2015 edition ezine 0402).
Hlola
PH 5.0 ~ 6.5
Ukucaca kunye nombala wesisombululo Kufuneka icaciswe ngokungenambala; ukuba ifufayo, ayiyi kuba yimbi kunomlinganiselo osemgangathweni we-turbidity No. 1th; Ukuba ukulungiswa kombala akufanele kube yinkcazo kunokuba isisombululo se-YellowName 1th isisombululo.
Ukunyanzela ukunyanzezela Isisombululo esipheleleyo kufuneka sibe necacileyo kwaye sibala emva kokushisa okuphezulu, kungekho ubisi obukhanyayo, akukho mvula
Isizathu sokuqinisekisa (iiprotheyini ezihlukeneyo) ≤50000
Iyonke i-asialic acid Ngokutsho kokubala komkhiqizo owomileyo, i-saliva equkethe i-acid kufuneka ibe yi-19.0 ~ 21.0%
Izinto ezinxulumene nazo I-asialic acid ≤0.3%; GD3, GD1a, ukungcola okungaziwa ≤ 0.5%; ukungcola kunye ≤2.0%
protein ≤1.0%
Ubunzima be-molecular weight ≤0.5%
Izixazululo zokuhlala I-Methanol ≤ 0.1%; i-acetone ≤ 0.3%; Trichloromethane ≤0.003%
amanzi ≤4.0%
Ukutshisa okutshayo ≤5.0%
Intsimbi enzima ≤20ppm
Ubunobumba obubi Ukuthobela iMimiselo
Izinto ezincinci Kufuneka ukuba ngokuhambelana nemimiselo (ubuninzi beendlela zokulawula)
Iiprojeni Kufuneka ukuba ngokuhambelana nemimiselo (ubuninzi beendlela zokulawula)
Imida ye micimbi Inani elipheleleyo leebhaktheriya ze-aerobic kufuneka libe yi <100cfu / g, kwaye inani elipheleleyo leebumba kunye neemvu kufanele kube <50cfu / g
Ecacileyo ≥98.0%

ekrwada I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Inkcazelo

I-sodium ye-Monosialotetrahexosylganglioside (37758-47-7), igama elifutshane linokuba yi-GM1, elikhishwe kwingqondo yengulube kwaye ilungu lechungechunge le-gangliosides eliqulethe i-aseic acid asele.

I-GM1 inokukhuthaza ukubuyiswa kwemisebenzi yengqondo emva kokulimala kwinkqubo yesantya ephakathi kwezinto ezinobangela, ukukhuthaza i-neuroplasticity. Iingcamango zibonisa ukulimala kweengqondo ze-GM1 zengqondo, ubuchopho obunzima bokubuyiselwa kweeseli zesigulane kumonakalo wentambo yomkhuhlane kunomphumo wokukhusela kwaye kukhuthaza inxaxheba yeseli.

Isigaba sangaphambili sesigaba sesi-2 sesilingo sonyango sibonisa, sinokunciphisa i-nealtoxicity (OIN) ye-oxaliplatin. Kodwa ayizange iqinisekiswe isilingo sesigaba III. Uvavanyo lwesigaba III lufunekayo ukuphanda umphumo kunye nokukhuselwa kwe-sodium Injection ye-monosialotetrahexosylganglioside yokukhusela i-OIN kwisifo somhlaza.

I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Inkqubo yezenzo?

I-GM1 (i-monosialotetrahexosylganglioside) "umzobo" wegriyoside, ilungu le-ganglio chungechunge lwe-gangliosides equle i-aseic acid asele. I-GM1 inezixhobo ezibalulekileyo zomzimba kunye nempembelelo ye-plastic neuronal kunye neendlela zokulungisa, kunye nokukhululwa kwe-neurotrophins kwingqondo. Ngaphandle komsebenzi wayo kwi-physiology yengqondo, i-GM1 isebenza njengendawo yokubopha i-toilin kunye ne-E. coli ukushisa kwe-labile enterotoxin.

benefits of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

I-Ganglioside GM1 ilungu leentsapho zegriyoside esetyenziswe kumazwe amaninzi kwaye kucatshangelwa njengonyango oluthembekileyo lokukhusela izifo ezininzi ze-neurological, ezibandakanya ukulimala kwe-cerebral ischemic. Iimpembelelo zokwelapha ze-GM1 ziye zabonakaliswa zombini kwi-neonates nakubantu abadala emva kokulimala kwengqondo yobuchopho.

kucetyiswa I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ipowder (37758-47-7) Isistim

Iidakamizwa zalawulwa kwi-dose ye-20-40 mg ngemihla ngejoza okanye ngesineke ye-intramuscular ngokweengcebiso zogqirha. Kwisigaba esichukumisayo seenguqu zentsholongwane: Iidakamizwa zisetyenzisiwe kwi-dose ye-100 mg imihla ngemihla nge-injection injection; Emva kweeveki ze-2-3, ngokuqhelekileyo kugcina inani le-20-40 mg ngeentsuku ezintandathu, i-dose yokuqala ye-500-1000 mg yayilawulwa yintlungu ye-Parkinson; ukususela ngosuku lwesibini, isilwanyana esasetyenzisiweyo kunye nomthamo we-200 mg ngemihla nge-subcutaneous, injection ye-intramuscular okanye i-intravenous drip for weeks of 18. xa le nkunkuma ilawulwa yi-injection engaphantsi okanye engenayo i-injection, kufuneka ichithwe kwaye ihlanjululwe emanzini ukwenzela ukuxiliswa kwaze kwaba yinkxalabo ye-10 mg / ml; xa i-Intravenous drip, i-drug dislike and diluted in 0.9% i-sodium chloride injection okanye i-5% ijoyiji yeglucose.

Imiphumela of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ipowder (37758-47-7)

Impembelelo yecala le-GM1 powder ngokuyinhloko isabela ngokukhawuleza emva kokusetyenziswa.


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Iziqulatho kunye nokuqulunqwa kwemveliso

I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

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