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I-rough Lorcaserin HCL powder (846589-98-8)

I-Lorcaserin hydrochloride powder i-serotonin i-2C (i-5-HT2C) i-agonist ye-receptor kunye nemithi elawulwa ngomlomo ekhuthaza ....


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1380kg / inyanga

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I-powder Lorinerin HCL powder (846589-98-8) ividiyo

I-powdered Lorcaserin HCL powder (846589-98-8) Iinkcukacha

Igama lemveliso I-Lorcaserin Hydrochloride powder
Igama leKhemikhali I-rough Lorcaserin HCL powder, iLorcaserin
uhlobo Numama BELVIQ
Iqela leziyobisi I-5-HT2C i-receptor inhibitor
Inani leCAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
I molecular Fi-ormula C11H15Cl2N
I molecular WSibhozo 232.15
IMasaisotopic Mass 231.058154899
Ukuxuba Point Akukho datha ekhoyo
Fukuhlaziywa kwakhona Point Akukho datha ekhoyo
I-Biological Half-Life Isiqingatha-ubomi se-lorcaserin malunga neeyure ze-11. I-powcaserin powder ipheliswa ngokuyinhloko kumchamo (i-92%) kunye nakwinkomo (2.2%)
umbala Powder
Umzimba Ubuncwane bamanzi: 0.0709 mg / mL
yoGcino Tukushisa -20 ° C.
Aukuguquka I-Serotonin 2C (HT2C) i-agonist ye-receptor yokulahleka kwesisindo.Ikhetha ukusetyenziswa kokutya kwaye ikhuthaze i-satiety centrally

I-rough Lorcaserin Hcl powder (846589-98-8) Inkcazo

I-Lorcaserin hydrochloride powder i-hydrochloride efunyenwe yi-lorcaserin powder enexabiso elifanayo le-hydrochloric acid. Isetyenziswe njengesicatshulwa sokulwa nokukhuluphala. I-Lorcaserin hydrochloride yi-5HT2c i-agonist i-receptor i-agonist ibonakaliswe ukusetyenziswa kubantu abadala abane-BMI ≥30, okanye abo abane-BMI ≥27 kwaye ubuncinane ubunzima obunxulumene nesisindo ezinjenge-hypertension, uhlobo lwe-2 yesifo sikashukela okanye i-dyslipidemia.I-powdererin Hydrochloride powder isebenza ngokunciphisa ukutya iyakuchukumisa ukuvakalelwa, kwaye kucatshangelwa ukuba igwebe ukukhawuleza kwezifo zentliziyo ye-valvular ezichaphazelekayo kunye nokusebenza kwe-5-HT2B receptors, indawo yengqondo eyaziwayo ukuba indima enkulu ekulawuleni indlala nokutya. Ngokusebenzisa le milambo, i-Lorcaserin hydrochloride powder inganciphisa ukusetyenziswa kokutya ngokunciphisa ukutya kunye nokwenza umntu azive epheleleyo nangemva kokutya ukutya okungaphantsi kunokuqhelekileyo. ivunyiwe namhlanje yi-FDA kwisigqibo esinqumlekileyo emva kweminyaka eyi-2 yokuhlolisisa.

I-Lorcaserin hydrochloride powder ibonakaliswe ngokukodwa njengendlela yokunciphisa ukutya okunokunciphisa-khalori kunye nokunyuka komzimba okwenziwe ukulawula ukunyuka kwamayeza kubantu abadala (i-BMI ye-30 kg / m2 okanye ngaphezulu) kunye nabantu abadala kakhulu (i-BMI ye-27 kg / m2 okanye ngaphezulu) ubuncinane ubunzima obunxulumene nesisindo.

I-Lorcaserin hydrochloride powder isetyenziselwa kunye nokutya kunye nokuzivocavoca ukuphatha ukukhuluphala. Ngamanye amaxesha kusetyenziswa ukuphatha ukukhuluphala okunokuthi kuhlobene nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.

I-Lorcaserin hydrochloride ayiyi kunyanga nayiphi na imeko yezempilo (njengentliziyo yesifo, isifo sikashukela, uxinzelelo lwegazi). Qhubeka uthatha nayiphi na enye imichiza ugqirha wakho oye wachaza ukuphatha le miqathango.

I-Lorcaserin Hcl powder (846589-98-8) Indlela yokusebenza

Nangona indlela echanekileyo ingaziwa, kukholelwa ukuba kuququzelele ukukhetha okukhethayo kwe-5-HT2C i-receptors kwi-anorexigenic pro-opiomelanocortin neurons kwi-nucleus ene-hypothalamus. Oku kuphumela ekunciphiseni ukutya nokutya ngokunciphisa ukukhululwa kwe-alpha-melanocortin i-hormone ekhuthaza, eyenzeka kwi-melanocortin-i-4 receptors.

I-Lorcaserin hydrochloride powder isebenza ngokulawula isondlo - ngokukodwa ngokusebenzisa i-brain receptors ye-serotonin, i-neurotransmitter eyenza ivakalelo lokuxhamla kunye nokwaneliseka. Ukungena kokutya kulawulwa yiziko elixhasayo, elisekhompyutheni ye-hypothalamus kunye nendlala ekhoyo kwi hypothalamus yangaphambili. Iziphumo ezahlukeneyo ezivela kumaziko aphezulu kunye namaphepheni ezinyantyambo ziguqula i-nucleus, apho kukho iintlobo ezimbini ze-neurons ezilawula ukutya okukhoyo. Okokuqala, iqela lokuvuselela ukutya lokuvelisa iprotheni ehlobene ne-agouti kunye neuropeptide Y; kwaye okwesibini, iqela lokutya lokutya eliqukethe i-cocaine kunye ne-amphetamine lilawulwa ngokubhaliweyo (IPART) kunye ne-pro-opiomelanocortin (POMC) neurons. I-POMC iqulethe i-5-HT i-2C receptors, xa isebenze ikhupha i-hormone ye-alpha-melanocyte-stimulating hormone (alfa-MSH) .Iimpawu ze-inuritory ne-stimulatory neurons zenza iiprojekmaular projekticular nucleus kwi-hypothalamus. I-nucleus ehambayo iqukethe i-melanocyte i-4 receptors (MC4R) evimbela ukondla kwimiqathango yokwelapha i-lorcaserin hydrochloride powder isebenza njenge-5-HT 2C agonist kwi-POMC neurons, leyo eyenza ikhuphe i-alfa MSH. I-alfa eqhubekayo i-MSH yenza i-MC4R kwi-nucleus yeparagrase kwi-hypothalamus, ekhokelela ekunciphiseni ukutya. Kwii-supratherapeutic doses, i-lorcaserin hydrochlorider yenza kwakhona kwi-5-HT 2B kunye ne-5-HT 2A receptors.

benefits I-Lorcaserin Hcl powder (846589-98-8)

  • I-Lorcaserin HCL powder yi-5-HT2C i-receptor agonist ecinga ukuba iyancipha ukunciphisa ukutya ngokusebenzisa inkqubo yePOMC ephakathi. Inzuzo yefowuni yeLorcaserin HCL:
  • I-Lorcaserin HCL powder isetyenziselwa kunye nokutya kunye nokuzivocavoca ukuphatha ukukhuluphala.
  • Ngesinye isikhathi i-Lorcaserin i-HCL powder isetyenziselwa ukunyanyisa ukukhuluphala okunokuthi kunxulumene nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.
  • I-Lorcaserin HCL powder ayiyi kunyanga nayiphi na imeko yezempilo (njengentliziyo yesifo, isifo sikashukela, uxinzelelo lwegazi).

Ukuphakanyiswa kwe-Lorcaserin Hcl powder (846589-98-8) Isisombululo

I-Lorcaserin i-HCL ipowder ifika kwifom yefribhethi kwaye ithathwa ngama1-2 ngamaxesha ngamaxesha, ngaphandle kokutya. I-Lorcaserin kufuneka isetyenziswe kunye nokunciphisa i-calorie yokutya kunye nesicwangciso sokusebenzisa.

I-dose ephakanyisiweyo ye-lorcaserin hcl powder ngu-10 mg olawulwa ngomlomo kabini ngosuku. I-Lorcaserin ingathathwa ngaphandle kokutya. I-Lorcaserin hcl kufuneka ishiywe kwizigulane ezingaphumeleli ukufezekisa ubuncinane i-5% yokulahleka kwesisindo ngeveki ye-12 ekubeni ezi zigulane azisoloko zifumana ukulahlekelwa kwesisindo esinokuthi zenze unyango oluqhubekayo.

Imiphumela I-Lorcaserin Hcl powder (846589-98-8)

I-Lorcaserin i-Hcl powder isetyenziselwa ukunyanga ukulawulwa kobunzima obungapheliyo kubantu abadala abane-index ye-mass mass (BMI) ye-30 okanye ngaphezulu (obomkhulu) njengongezwa kwindlela yokunciphisa i-calorie kunye nokuzivocavoca. Kuvunyiwe ukuba kusetyenziswe abantu abadala abane-BMI ye-27 okanye ngaphezulu (obuninzi ngaphezu komzimba) kwaye obuncinane ubunzima obunxulumene nesisindo ezifana nokunyuka kwegazi (i-blood pressure), okanye i-cholesterol ephezulu (i-dyslipidemia). Nangona kunjalo, nayo inokuba nemiphumo emibi. Nje ngezantsi:

Tiziphumo eziqhelekileyo ezichaphazelekayo:

  • -Ukufunda,
  • -Izakhono,
  • -Ukuxhatshazwa,
  • -Ngenxa,
  • -Sula umlomo,
  • -Isivumelwano, kunye
  • - I-hepoglycemia (ushukela wegazi ophantsi).

Ezinye iziqhelo ezingekho phantsi kodwa ezibi kakhulu ezinxulumene ne-lorcaserin ziquka:

  • -Qala iingxaki zeviniki,
  • -Changisisa kwingqalelo okanye kwimemori,
  • -Engxaki zeengqondo,
  • Ukuxhatshazwa okanye iingcinga zokuzibulala,
  • -Ukuphazamiseka,
  • -Injabulo yentliziyo,
  • -Ukuhla kwe-cell cells count, kunye
  • - Ukwanda kwehomoni, iprolactin.


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Iziqulatho kunye nokuqulunqwa kwemveliso

I-FDA ivunyelwe i-Lorcaserin i-HCL ye-Treatment of Obesity

Ucaphulo

  1. U-Bohula, u-Erin A., u-Wiviott, uStephen D., uMcGuire, uDarren K., i-Inzucchi, uSilvio E., kunye no-Al: Ukukhusela kwe-Carcasculars ye-Lorcaserin kwi-Overweight or Peseents, I-New England Journal of Medicine, 2018
  2. Ukutya kunye noLawulo lweeMithi, iiMilk Target Ixesha elide lokuLawula isisindo, kwi-Intanethi, ipapashwe nge-17 Julayi 2012
  3. U-Ashley Gustafson, uCammile King, uJoseph AR, iZiko leSizwe loLwazi lwe-Biotechnology, i-PMC Articles, MediMedia, i-USA Lorcaserin (i-Belviq), i-Intanethi, ngo-Septemba 2013

I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

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