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I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

I-Lorcaserin hydrochloride hemihydrate powder i .......


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1280kg / inyanga

inkcazelo

I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5) ividiyo

I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5) Iinkcukacha

Igama lemveliso I-Lorcaserin hydrochloride hemihydrate powder
Igama leKhemikhali I-Lorcaserin hydrochloride, (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine i-hydrochloride hemihydrate; (R) -8-chloro-2,3,4,5-tetrahydro-1-methyl-1h-3-benzazepine i-hydrochloride hemihydrate
uhlobo Numama Belviq
Iqela leziyobisi I-5-HT2C i-receptor inhibitor
Inani leCAS 856681-05-5
InChIKey WRZCAWKMTLRWPR-VSODYHHCSA-N
I molecular Fi-ormula C22H32Cl4N2O
I molecular WSibhozo 482.31
IMasaisotopic Mass 480.1268745
Ukuxuba Point Akukho datha ekhoyo
Fukuhlaziywa kwakhona Point Akukho datha ekhoyo
I-Biological Half-Life I-Lorcaserin inomdla wesiqingatha se-plasma ye ~ ii-11 iiyure
umbala Powder
Umzimba Ubuncwane bamanzi 0.0709 mg / mL
yoGcino Tukushisa Akukho datha ekhoyo
Aukuguquka I-Lorcaserin hydrochloride hemihydrate powder esetyenziswe njengesilwanyana esilwa ne-anti-obesity. Inendima njengesondlo esinxilisayo kunye ne-agonist ye-serotonergic.

I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5) Inkcazelo

I-Lorcaserin hydrochloride i-hemihydrate powder yi-hydrate leyo ifom ye-hemihydrate ye-lorcaserin hydrochloride. Isetyenziswe njengesicatshulwa sokulwa nokukhuluphala. Inendima njengesondlo esinxilisayo kunye ne-agonist ye-serotonergic. Iqukethe i-lorcaserin hydrochloride.

I-Lorcaserin hydrochloride i-hemihydrate powder isebenzisa ukunyanyisa ukukhuluphala okunxulumene ne-cholesterol ephakamileyo, uxinzelelo lwegazi oluphezulu okanye udidi lwe-2 yesifo sikashukela.

I-FDA ivumile i-Raw Lorcaserin hydrochloride i-hemihydrate powder kubantu abanokugqithisa (kunye ne-index mass mass, okanye i-BMI, ye-30 okanye ngaphezulu) okanye ngubani ogqithiseleyo (kunye ne-BMI ye-27 okanye ngaphezulu) kwaye ubuncinane ubunzima obuncinane- imeko enempilo enxulumene neyohlobo lwe-2 yesifo sikashukela, uxinzelelo lwegazi oluphezulu okanye i-cholesterol ephezulu.

I-Lorcaserin hydrochloride i-hemihydrate powder isebenze ngokulawula ukutya - ngokukodwa ngokusebenzisa i-brain receptors ukuze i-serotonin, i-neurotransmitter edala ukuvakalelwa. I-Serotonin nayo ibandakanyeka kwimvakalelo; ezininzi izidakamizwa ezixhatshazelayo zisebenza ngokuthintela ukubuyiswa kwakhona kwe-serotonin kunye nokugcinwa kweengqondo eziza kuhlamba kwiikhemikhali. Abaphandi kwi-Arena bathi izidakamizwa zabo zenzelwe ukufumana kuphela i-serotonin receptors ezichaphazela ukutya.

I-Lorcaserin hydrochloride i-hemihydrate powder (856681-05-5) Indlela yokusebenza

I-Lorcaserin ikholelwa ukuba iyancipha ukusetyenziswa kokutya kwaye ikhuthaze i-satiety ngokukhetha i-5-HT2C i-receptors kwi-anorexigenic pro-opiomelanocortin neurons e-hypothalamus. Indlela echanekileyo yesenzo ayiyazi.

I-Lorcaserin kwi-dose yemihla ngemihla ecetyiswayo idibanisa kunye ne-5-HT2C i-receptors xa kuthelekiswa ne-5-HT2A kunye ne-5-HT2B i-receptors (jonga i-5), nezinye i-5-HT i-receptor subtypes, i-5-HT, kunye ne-5-HT. .

isicelo I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

  • Ukuxhalabisa ukutya: Ummeli osetyenziswayo ukunciphisa ukutya.
  • i-serotonergic agonist: I-arhente enobudlelwane be-serotonin receptors kwaye iyakwazi ukulinganisa imiphumo ye-serotonin ngokukhuthaza umsebenzi we-physologic kwi-cell receptors. Ama-agonists aseSerotonin asetyenziswa njengama-antidepressants, anxiolytics, kunye nokunyangwa kweengxaki ze-migraine.

Unconywe i-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

Ekubeni ulwazi olufanelekileyo malunga nokusetyenziswa kweLorcaserin hydrochloride hemihydrate ayinakufumaneka, le nkcazelo elandelayo yenzelwe kuphela:

I-Lorcaserin HCL powder I-846589-98-8 ifika kwifom yefribhethi kwaye ithathwa ngamaxesha e-1-2 ngosuku, okanye ngaphandle kokutya. I-Lorcaserin kufuneka isetyenziswe kunye nokunciphisa i-calorie yokutya kunye nesicwangciso sokuzilolonga.

I-dose ephakanyisiweyo ye-lorcaserin ngu-10 mg olawulwa ngomlomo kabini ngosuku. I-Lorcaserin ingathathwa ngaphandle kokutya. I-Lorcaserin kufuneka ishiywe kwizigulane ezingaphumeleli ukufezekisa ubuncinane i-5% yokulahleka kwesisindo ngeveki ye-12 ekubeni ezi zigulane azikwazi ukufumana ukulahleka kwesisindo esinomdla kunye nokunyanga okuqhubekayo.

iinzuzo I-Lorcaserin hydrochloride i-hemihydrate powder (i-856681-05-5)

I-Lorcaserin hydrochloride i-hemihydrate powder yi-5-HT2C i-receptor agonist ekucingelwa ukunciphisa ukutya okudityanisiweyo ngokusebenzisa inkqubo yePOMC ephakathi. Inzuzo yefowuni yaseLorcaserin HCL:

  • I-Lorcaserin hydrochloride i-hemihydrate powder isetyenziswe kunye nokutya kunye nokuzivocavoca ukuphatha ukukhuluphala.
  • Ngesinye isikhathi i-Lorcaserin hydrochloride i-hemihydrate powder isetyenziselwa ukuphatha ukukhuluphala okunokuthi ihlobene nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.
  • I-Lorcaserin hydrochloride hemihydrate powder ayiyi kunyanga nayiphi na imeko yezempilo (njengentliziyo yesifo, isifo sikashukela, uxinzelelo lwegazi).

Imiphumela I-Lorcaserin hydrochloride hemihydrate powder (856681-05-5)

I-Lorcaserin hydrochloride i-hemihydrate powder isetyenziselwa ukunyanga ukulawulwa kobunzima obungapheliyo kubantu abadala abane-index ye-mass mass (BMI) ye-30 okanye enkulu (obomkhulu) njengongezwa kwindlela yokutya yokunciphisa i-calorie kunye nokuzivocavoca. Kuvunyiwe ukuba kusetyenziswe abantu abadala abane-BMI ye-27 okanye ngaphezulu (obuninzi ngaphezu komzimba) kwaye obuncinane ubunzima obunxulumene nesisindo ezifana nokunyuka kwegazi (i-blood pressure), okanye i-cholesterol ephezulu (i-dyslipidemia). Nangona kunjalo, nayo inokuba nemiphumo emibi. Nje ngezantsi:

Tiziphumo eziqhelekileyo ezichaphazelekayo:

  • -Ukufunda,
  • -Izakhono,
  • -Ukuxhatshazwa,
  • -Ngenxa,
  • -Sula umlomo,
  • -Isivumelwano, kunye
  • - I-hepoglycemia (ushukela wegazi ophantsi).

Ezinye iziqhelo ezingekho phantsi kodwa ezibi kakhulu ezinxulumene ne-lorcaserin ziquka:

  • -Qala iingxaki zeviniki,
  • -Changisisa kwingqalelo okanye kwimemori,
  • -Engxaki zeengqondo,
  • Ukuxhatshazwa okanye iingcinga zokuzibulala,
  • -Ukuphazamiseka,
  • -Injabulo yentliziyo,
  • -Ukuhla kwe-cell cells count, kunye
  • - Ukwanda kwehomoni, iprolactin.


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I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

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