α-ketoglutaric

I-Phcoker inamandla okwenza imveliso ngobuninzi kunye nokuhanjiswa kweCalcium 2-oxoglutarate kunye neAlfa-Ketoglutaric Acid phantsi kwemeko ye-cGMP.

Ngawaphi amanye amagama i-alpha-ketgoglutaric acide eyaziwayo?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, IAlfa-Cétoglutarate, IAlfa-Cétoglutarate Cate de Cadine de Arginine, Isidibanisi , IAlpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alfa Ketoglutarate, Alfa Ketoglutaric Acid, Alpha KG, Alfa KG, Alfa KG, Alfa KG. -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoganutic Iasidi.

Yintoni ialpha-ketoglutaric acid?

I-Alpha-ketoglutaric (AKG) yi-asidi ye-organic ebalulekileyo kwimetabolism efanelekileyo yazo zonke ii-amino acid kunye nokudluliswa kwamandla eselfowuni kumjikelo we-citric acid. Ingumanduleli we-glutamic acid, i-amino acid engabalulekanga ebandakanyeka kwiprotein synthesis kunye nommiselo wamanqanaba eglucose egazini. Ngokudibanisa ne-L-glutamate, i-AKG inokunciphisa amanqanaba e-ammonia ayenziwe kwingqondo, izihlunu kunye nezintso, kunye nokunceda ukulinganisa i-nitrogen chemistry yomzimba kunye nokuthintela ukugqithisa kwe-nitrogen kwizicubu zomzimba kunye neencindi. Abantu abaneeprotheyini eziphezulu zokutya, usulelo lwebhakteria, okanye isisu sedysbiosis banokuxhamla kwi-AKG yokuncedisa ukunceda amanqanaba e-ammonia kunye nokukhusela izicubu.

Abanye abantu bathatha i-alpha-ketoglutarate ukuphucula ukusebenza kweembaleki. Ababoneleli bezongezo zemidlalo ezongezelelekileyo zokuthintela ibango i-alpha-ketoglutaric acid inokuba sisongezo esibalulekileyo kukutya okufanelekileyo kunye noqeqesho lwembaleki efuna ukusebenza okuphezulu. Basekela eli bango kwizifundo ezibonisa i-ammonia eyongezelelweyo emzimbeni inokudibanisa ne-alpha-ketoglutarate ukunciphisa iingxaki ezinxulumene ne-ammonia eninzi (i-ammonia toxicity). Kodwa, ukuza kuthi ga ngoku, kuphela kwezifundo ezibonisa i-alpha-ketoglutarate inokunciphisa ityhefu ye-ammonia eyenziwe kwizigulana ze-hemodialysis.

Ababoneleli ngezempilo ngamanye amaxesha banika i-alpha-ketoglutarate ngaphakathi (nge-IV) yokuthintela ukwenzakala kwentliziyo ebangelwa ziingxaki zokuhamba kwegazi ngexesha lotyando lwentliziyo kunye nokuthintela ukuphazamiseka kwemisipha emva kotyando okanye umothuko.

Iindlela zokusebenza kweAlfa-Ketoglutaric acid

Inkqubo ngqo yokusebenza kwe-α-Ketoglutarate ayikacaciswa. Ezinye zezenzo ze-α-Ketoglutarate zibandakanya ukwenza kumjikelo we-Krebs njengophakathi, ukusabela kotshintsho ngexesha lokudityaniswa kwe-amino acid, ukwenza i-glutamic acid ngokudibanisa ne-ammonia, kunye nokunciphisa i-nitrogen ngokudibanisa nayo ngokunjalo. Ngokuphathelele kwizenzo ze-α-Ketoglutarate kunye ne-ammonia, kucetyiswa ukuba i-α-Ketoglutarate inokunceda abaguli abane-propionic academia abanamanqanaba aphezulu e-ammonia kunye namanqanaba asezantsi e-glutamine / glutamate egazini labo. Ngenxa yokuba i-endo native glutamate / glutamine iveliswa kwi-α-Ketoglutarate, i-propionic acidemia yezigulana zinemveliso engalunganga ye-α-Ketoglutarate kunye nokongezwa kwe-α-Ketoglutarate kufuneka iphucule imeko yezi zigulana. Olunye uphononongo oluninzi lovavanyo luye lwabonisa ukuba ukulawulwa kwe-α-Ketoglutarate kwisondlo sabazali esinikwe abaguli abasebenza emva kokusebenza kuncede ekunciphiseni ukuhla kweprotein yemisipha edla ngokubonakala emva kotyando. Oku kuncipha kokudibana kwemisipha kucingelwa ukuba kungenxa yamanqanaba asezantsi kakhulu α-Ketoglutarate.

I-alpha ketoglutaric acid (AKG) isongezelelo- Zithini izibonelelo zeAlpha ketoglutaric acid?

IAlpha-Ketoglutarate (AKG) njengesiXhobo sokuSebenza seMbaleki
I-Alpha ketoglutaric acid, okanye i-Alpha-ketoglutarate yimveliso ye-mitochondria kwaye idlala indima ebalulekileyo kutshintsho lokutya lube ngamandla. Ikwangumthombo we-glutamine kunye ne-glutamate. Kwizihlunu, i-glutamine kunye ne-glutamate inhibit breakdown protein kunye nokwanda kweprotein synthesis.

I-Alpha-ketoglutarate inyusa ukwakheka kwethambo. Ilawula ukuhlanganiswa kwe-collagen ngokunyusa inani lee-molecule ezikhoyo kwi-synthesis. I-Collagen yinto ebalulekileyo yamathambo.

I-Alpha-ketoglutarate ivuselela imveliso ye-insulin-efana nokukhula kwe-1 kunye ne-hormone yokukhula. Zombini ezi zihomoni ezilawula ukuphinda zisebenze kwakhona kunye nokwenziwa kwethambo elitsha.

Ialpha ketoglutaric acid izibonelelo zokuguga
Izifundo zibonise ukuba i-AKG inokuthi inyange iimeko ezininzi xa ithathwa njengoko kuyalelwe.

Nangona kunjalo, kukho ezinye izinto ezibonisa ukuba i-Alpha-Ketoglutarate (AKG) inokunceda kwizakhiwo ezichasene nokwaluphala.

Olunye uphononongo olukhulu olwenziwe kwiBuck Institute yoPhando ngokuGuga kunye noPonce de Leon Health bafumanise impilo ephuculweyo ngama-60% kufundo lwabo lwezilwanyana ezanyisayo.

α-ketoglutaric
I-AKG yandisa ixesha lokuphila kwabantu abadala be-elegans. (A) I-AKG yandisa ixesha lokuphila kweentshulube ezindala. (B) Umjikelo wokuphendula ngethamo lesiphumo se-AKG kubomi obude.
Ukongeza, iPonce De Lon Health (PDL) ikhuphe ingxelo yovavanyo, ingxelo ebonisa ukuba emva kwesiqingatha sonyaka, iminyaka yomzimba yezifundo yehle nge-8.5 yeminyaka ubudala emva kokuthatha i-alpha-ketoglutarate (AKG) equlethwe kwinkampani.

Ezinye iikhompawundi, ezinje ngokuguga iziyobisi i-rapamycin kunye nonyango lweswekile i-metformin, zibonise iziphumo ezifanayo kuvavanyo lwempuku. Kodwa i-AKG yenziwe ngokwendalo ziigundane kwaye yimizimba yethu, kwaye sele ithathwa njengekhuselekileyo ukuba ingadliwa ngabalawuli.

Izinto ekufuneka sizinikele ingqalelo kukuba i-alpha ketoglutaric acid emsulwa ine-asidi kakhulu kwaye akukho lula ukuyitya. Izixhobo zokuqina komzimba kwintengiso zongezwa nge-arginine-α-ketoglutarate (AAKG), eyona nto iphambili kuyo yi-arginine, ngelixa enye isetyenziswa yiPonce De Lon Health yi-α-ketoglutarate calcium.

IAlfa-ketoglutarate ikwanazo neepropathi ezonyusa amajoni omzimba
I-AKG ikwabizwa ngokuba sisakhi sezakhi mzimba kwaye idlala indima ebalulekileyo kwimetabolism yomzimba jikelele. Sele isaziwa ukuba i-AKG ngumthombo obalulekileyo we-glutamine kunye ne-glutamate, ichazwa njenge-glutamine homologue kunye nesiphumo. Emzimbeni, iguqulelwe kwi-glutamine. I-Glutamine inokunyusa amanqanaba eeseli ezimhlophe zegazi (ii-macrophages kunye nee-neutrophils). I-AKG njenge-glutamine homologue inezinto ezonyusa amandla, inokugcina isithintelo esiswini, inyuse iiseli zomzimba kunye nomsebenzi we-neutrophils kunye ne-phagocytosis, ukunciphisa ukuhanjiswa kwebhakteriya kwi vivo.

Imbekiselo:

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