I-Urolithin powder

I-Phcoker inamandla okwenza imveliso ngobuninzi kunye nokuhanjiswa kwe-urolithin a, urolithin b kunye ne-Urolithin A 8-Methyl Ether phantsi kwemeko ye-cGMP.

Yintoni iUrolithin A?

I-Urolithin A sisixhobo se-metabolite esivela kutshintsho lwe-ellagitannins yi-gut bacteria. Yeyeklasi yeekhompawundi eziphilayo ezaziwa ngokuba yi-benzo-coumarins okanye i-dibenzo-α-pyrones. I-Urolithin A ibonakalisiwe ukukhuthaza i-mitophagy kunye nokuphucula impilo yemisipha kwizilwanyana ezindala nakwiimodeli zangaphambi kokuguga. Okwangoku, ikwabonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene nesifo se-Alzheimer's.

I-Urolithin A powder iyimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin A yenziwa yimetabolism evela kwiipolyphenol ezifumaneka kumantongomane nakwiziqhamo, ngakumbi iirharnate. Izanduleli zayo - i-ellagic acid kunye nee-ellagitannins- zikho kuyo yonke indawo kwindalo, kubandakanya nezityalo ezityiwayo, ezinje ngeerharnate, amaqunube, iirasibheri, i-walnuts, iti kunye nemidiliya ye-muscat, kunye neziqhamo ezininzi ezikweleenjiko.

Ukusukela nge-2000s, i-urolithin A ibisoloko iphantsi kwezifundo zokuqala ngokubhekisele kwiziphumo zebhayiloji.

Urolithin usebenza njani?

I-Urolithin A yi-urolithin, i-microbial metabolite yabantu yokutya okuvela kwi-ellagic acid (ezifana ne-ellagic acid). Kwimatabolism yamathumbu emathunjini, i-ellagitannin kunye ne-ellagic acid zikhokelela ekubunjweni kwee-urolithins ezisebenzayo A, B, C kunye no-D. Phakathi kwazo, i-urolithin A (UA) yeyona metabolite yamathumbu isebenzayo nesebenzayo, enokusetyenziswa njenge anti -yokudumba kunye ne-antioxidant.

Kwizifundo zaselebhu, kubonisiwe ukuba i-urolithin A inducos mitochondria, ethi ibuyise ngokukhetha i-mitochondria ngokusebenzisa i-autophagy. I-Autophagy yinkqubo yokususa i-mitochondria enesiphene emva kokulimala okanye uxinzelelo, kwaye iyasebenza ngexesha lokuguga. ezantsi nezantsi. Esi siphumo siye sajongwa kwiindidi zezilwanyana ezahlukeneyo (iiseli ezanyisayo, iimpuku kunye neCaenorhabditis elegans).

Nangona kunjalo, ngenxa yokuba umthombo we-ellagitannin wahlukile, ukwakhiwa kweqela ngalinye le-bacteria kuya kwahluka, ke ukusebenza ngokukuko kwe-urolithin A kwahluke kakhulu ebantwini, kwaye abanye abantu abanakho ukuguqula.

Urolithin Izibonelelo

I-Urolithin A (UA) kukutya kwendalo, imetabolite ephuma kuluntu oluncinci. Inezibonelelo ezahlukeneyo zempilo, kubandakanya ukunciphisa ukubonakalisa ukuvutha, iziphumo ezichasene nomhlaza kunye nokuthintela ukuqokelelwa kwe-lipid.

Njengoyena metabolite wamathumbu asebenzayo nesebenzayo, i-urolithin A (UA) inokusebenza njenge-anti-inflammatory kunye ne-antioxidant esebenzayo. Inokukhuthaza i-mitochondrial phagocytosis kwizilwanyana ezindala kunye neemodeli zangaphambi kokuguga kunye nokuphucula impilo yemisipha.

Ngaba i-Urolithin A inokusetyenziswa njengezongezo?

Ngo-2018, i-US Food and Drug Administration yabeka i-urolithin A njengesixhobo esikhuselekileyo ekutyeni okanye kwimveliso yokutya, ngezixa ezisukela kwi-250 milligrams ukuya kwi-1 gram ngokusebenza.

Ngaba zikhona iziphumo ebezingalindelekanga ze-Urolithin A?

Izifundo zokhuseleko kubantu abadala zibonakalise ukuba i-urolithin A inyamezeleke kakuhle. Kwizifundo ze-vivo khange zichonge ukuba ngaba ikhona na into enetyhefu okanye iziphumo ezichaseneyo zokutya kwe-urolitin A yokutya.

Kwakhona, ukhuseleko lwexesha elide lokuncedisa i-Urolithin A kunye neerharnate ayaziwa, nangona unyango lwexesha elifutshane kunye neerharnate lukhuselekile.

Yintoni urolithin B? I-Urolithin B powder?

I-Urolithin B powder (i-CAS NO: 1139-83-9) yi-urolithin, uhlobo lwee-phenolic compounds eziveliswa emathunjini omntu emva kokufakwa kokutya okune-ellagitannins ezinje ngerharnate, amaqunube, iirasibheri ezibomvu, iialnuts okanye iwayini ebomvu ye-oki. . I-Urolithin B ifumaneka kumchamo ngohlobo lwe-urolithin B glucuronide.

I-Urolithin B inciphisa ukonakaliswa kweprotein kwaye inciphisa i-hypertrophy yemisipha. I-Urolithin B inqanda umsebenzi we-aromatase, i-enzyme eguqula i-estrogen kunye ne-testosterone.

I-Urolithin B yimveliso yendalo ene-antiproliferative kunye ne-antioxidant. I-Urolithin B ibonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene neSifo se-Alzheimer's.

I-Urolithin B yiyimathumbu yentsholongwane yezibalo ze-ellagitannis kwaye ibonisa isenzo esinamandla se-anti-oxidant kunye ne-pro-oxidant kuxhomekeka kwinkqubo kunye neemeko. I-Urolithin B inokubonakalisa kwakhona i-estrogenic kunye / okanye imisebenzi echasene ne-estrogenic.

Urolithin B usetyenziselwa ntoni? Izibonelelo ze-Urolithin B (UB)

Izibonelelo zika-Urolithin B:

Ukukhuthaza iProteni yeMisipha yeNtsebenzo

Iyanciphisa ukonakala kweeproteni zemisipha

Ngamana unokuba neempembelelo zoKhuselo

Ngamana unokuba nePropathi yeAnti-Aromatase

I-Urolithin B yobunzima bemisipha

I-Urolithin B inokudambisa ukulimala kwemisipha okwenzeka ngexesha lokuzivocavoca kakhulu kwaye ikhusele izihlunu kuxinzelelo olubangelwa kukutya okunamafutha aphezulu. Uphando lweklinikhi ngeUrolithin B kwiimpuku lufumanise ukuba luphucula ukukhula kwe-myotubes kunye nokwahlula ngokwandisa ukumiliselwa kweprotein. Ibonakalise ukubanakho ukuthintela umqobo we-ubiquitin-proteinasome pathway (UPP), eyona nto iphambili kwinkqubo yokubonisa iprotheyini. Ikwakhuthaza i-hypertrophy yemisipha kunye nokuncipha kwe-atrophy yemisipha.

Xa uthelekisa i-testosterone, i-Urolithin B xa ithathwa kwi-15 M yenyusa umsebenzi we-androgen receptor ngo-90% ngelixa i-testosterone yayikwazi kuphela ukufeza imisebenzi eyandayo ye-receptor eyi-50% kwi-100uM. Oku kuthetha ukuba kuthatha ubuncinci i-Urolithin B ukunyusa umsebenzi we-androgen ngakumbi ke inani eliphakamileyo le-testosteronewhich inyusa umsebenzi we-androgen ngokufanelekileyo.

Ngaphaya koko, i-15uM esebenzayo kakhulu ye-Urolithin B yamandla aphambili emisipha nge-96% xa kuthelekiswa ne-100uM ye-insulin, eyakha inkqubo yemisipha yeproteni ngokusebenzisa kakhulu ama-61%. Inkolelo kukuba kuthatha ixesha elide kakhulu ukuba i-Urolithin B inyuse ukwandiswa kweprotheni yemisipha ngomgangatho ophezulu wokusebenza.

Olu phononongo lubonisa ukuba i-Urolithin B inokuyithintela i-protein catabolism ngelixa ngaxeshanye yandise ukwakheka kweprotein, sisithako sendalo esinceda ukwakha umsipha obuthathaka ngelixa uthintela ukuchitheka kwemisipha.

I-Urolithin B yenye yeethumbu zeemetabolites ezincinci ze-ellagitannins, kwaye ineziphumo ezichasene nokudumba kunye ne-antioxidant. I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-I VerBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye yonyusa iphosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wobunzima bemisipha.

Yintoni iUrolithin A 8-Methyl Ether?

I-Urolithins ziyimetabolism yesibini ye-ellagic acid ethathwe kwi-ellagitannins. Ebantwini i-ellagitannins iguqulwa yi-gut microflora ibe yi-ellagic acid eguqulwa i-urolithins A, urolithin B, urolithin C kunye ne-urolithin D kumathumbu amakhulu.

I-Urolithin i-8-Methyl Ether iyimveliso ephakathi ngexesha lokuqulunqwa kwe-Urolithin A. Yinto ebalulekileyo yeselite metabolite ye-ellagitannin kwaye ineempawu ze-antioxidant kunye ne-anti-immune.

Isebenza njani i-Urolithin A 8-Methyl Ether?

(1) Iipropathi ze-Antioxidant

I-Urolithin A-8-Methyl Ether inefuthe le-antioxidant ngokunciphisa i-radicals yasimahla, ngakumbi ukunciphisa amanqanaba e-oksijini esebenzayo (ROS) kwiiseli, kunye nokuthintela i-lipid peroxidation kwiintlobo ezithile zeseli.

(2) Iipropathi ezichasayo

I-Urolithin A-8-Methyl Ether inezixhobo ezichasayo ngokuthintela ukuveliswa kwe-nitric oxide. Banqanda ngokukodwa ukubonakaliswa kweprotein ye-nitric oxide synthase (iNOS) kunye ne-mRNA ebangela ukudumba.

Urolithin A 8-Methyl Ether izibonelelo

I-Urolithin A-8-Methyl Ether iyimveliso ephakathi kwinkqubo ye-Urolithin A, kunye ne-metabolite yesibini ye-ellagitannin, ene-antioxidant kunye ne-anti-inflammatory properties. Njenge-metabolite ye-Urolithin A, inokuba nezibonelelo ezithile ze-Urolithin A:

(1) Inokwandisa ixesha lokuphila;
(2) Nceda uthintele umhlaza wedlala lobudoda;
(3) Ukuphuculwa kwengqondo;
(4) Ukubakho ukunciphisa umzimba

Ukusetyenziswa kwe-Urolithin A 8-Methyl Ether isongezo?

I-Urolithin A izongezo zifumaneka ngokulula kwintengiso njengemithombo yokutya ene-ellagitannin. Njengemveliso ye-metabolic ye-Urolithin A, Urolithin A 8-Methyl Ether inokusetyenziswa kwizongezo.

Nangona kunjalo, akukho datha zininzi malunga nolwazi lwenkxaso, kwaye uphando oluninzi luyafuneka.

Imbekiselo:

  1. UGarcia-Munoz, uCristina; UVaillant, uFabrice (2014-12-02). "Isiphelo seMetabolic ye-Ellagitannins: Iziphumo zeMpilo, kunye nePhando lokuPhononongwa kokutya okuSebenzayo okusebenzayo". Uphengululo oluBalulekileyo kwiSayensi yezoKutya kunye nesondlo. 54 (12): 1584-1598. ikhonkco: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. IINKCUKACHA:
  2. URyu, D. okqhubekayo. I-Urolithin A induces mitophagy kwaye iyolula ubomi kwi-C. elegans kwaye yonyusa ukusebenza kwemisipha kwiintonga. Nat. IMed. 22, 879-888 (2016).
  3. "Isaziso se-FDA GRAS GRN No. 791: urolithin A". Ulawulo lokutya kunye neziyobisi e-US. 20 Disemba 2018. Ibuyiswe ngomhla wama-25 Agasti 2020.
  4. Singh, A .; UAndreux, uP.; UBlanco-Bose, W.; Ryu, D.; Aebischer, P.; I-Auwerx, J.; I-Rinsch, C. (2017-07-01). "I-urolithin A elawulwa ngomlomo ikhuselekile kwaye imodareyitha ii-biomarker zemisipha kunye ne-mitochondrial kubantu abadala". Ubutsha ekwaluphaleni. 1 (suppl_1): 1223-1224.
  5. UHeilman, uJacqueline; UAndreux, uPénélope; Tran, Nga; Rinsch, uChris; UBlanco-Bose, uWilliam (2017). "Uvavanyo lokhuseleko lwe-urolithin A, imetabolite eveliswe sisicwili somntu esiswini ekutyeni ukutya kwezityalo ezivela kwi-ellagitannins kunye ne-ellagic acid". Ukutya kunye neChemical Toxicology. 108 (Pt A): 289–297. ikhonkco: 10.1016 / j.fct.2017.07.050. IINKCUKACHA: