I-Palmitoylethanolamide (PEA) Ngqi kelelo

Kukho ingxelo yokuba uLawulo lwezoKutya kunye neDrug luvunyiwe ukuba lungenise isicelo solingo lweklinikhi ukunyanga i-COVID-19 ngokusebenzisa ichiza elenziweyo elingisa isenzo semolekyuli efumaneka kwentsangu.

Iyeza elenziweyo, elibizwa ngokuba yi-palmitoylethanolamide (micro PEA), kukholelwa ukuba lisebenza njenge-anti-inflammatory. I-Palmitoylethanolamide (i-PEA) "yenzeka ngokwendalo enamafutha acid" efana ne-endocannabinoid, enye yeemolekyuli ezifumaneka kwi-cannabis ejolise kwii-receptors ze-CB2. Ii-receptors ze-CB2 kucingelwa ukuba zilungisa zombini ukudumba kunye nentlungu kuwo wonke umzimba womntu.

Kuba [i-PEA encinci] isetyenzisiwe eYurophu kangangeminyaka engama-20, abanye ababoneleli bezempilo base-Italiya babekhuthaza ukusetyenziswa kwe-PEA encinci ukunyanga abaguli be-COVID-19 kwaye babefumana impumelelo.

I-COVID-19 enzima ibonakaliswa yimpendulo yokuvuvukala okungaphezulu kunokukhokelela kwisiqhwithi se-cytokine. “I-PEA encinci ayisosibulala ntsholongwane, kodwa bayakholelwa ukuba ingayinciphisa impendulo yomzimba, enokubulala.

 

Yintoni iPalmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) lipid eyenzeka ngokwemvelo emzimbeni wethu kudidi lwamafutha acid amide. Yiyo ke le lipid yendalo. I-PEA nayo iveliswa ngokwemvelo kwizityalo nakwizilwanyana.

IPalmitoylethanolamide (PEA) inokufumaneka ekutyeni okunje ngobisi, iimbotyi zesoya, ii-ertyisi zegadi, i-lecithin yesoya, inyama, amaqanda kunye namandongomane.

Ophumelele amabhaso kaNobel uLevi-Montalcini uchonge iPalmitoylethanolamide (PEA) njengemolekyuli eyenzeka ngokwendalo, ichaza ixabiso layo kunyango losulelo olungapheliyo kunye neentlungu. Emva kokufumanisa kwakhe, amakhulu ezifundo zenzululwazi zenziwe ukubonisa ukuba iyasebenza kwaye ikhuselekile ukuyisebenzisa. IPalmitoylethanolamide (PEA) ichazwa kwimibhalo yesayensi njenge Iipilisi zentlungu zendalo.

 

I-Palmitoylethanolamide (PEA)

IPalmitoylethanolamide izibonelelo - Yintoni esetyenziselwa Palmitoylethanolamide?

I-Palmitoylethanolamide (i-PEA) yi-fatty acid amide kwaye yenziwe kwaye isebenze ngaphakathi komzimba wethu ukulawulwa kwemisebenzi eyahlukeneyo. It is a endo native fatty acid amide, belonging to the class of nuclear factor agonists. I-Palmitoylethanolamide (i-PEA) eneneni ifunyenwe ngokubanzi kwiimodeli ezininzi zezilwanyana ezinokukrala, kunye novavanyo oluninzi lwezonyango.

Yipilisi yeentlungu yendalo kwaye inokusetyenziselwa iintlungu ezingapheliyo kunye nokudumba. Ikwasebenzisa ezinye izibonelelo ezinje nge-neuropathic ache, i-fibromyalgia, isifo sokuqina kwamathambo, ukuphindaphindeka kokulimala koxinzelelo, usulelo lomgudu wokuphefumla, kunye nezinye iingxaki ezininzi.

Ezinye zezibonelelo ze-Palmitoylethanolamide ezixeliweyo zibandakanya;

 

i. Ixhasa impilo yengqondo

Izibonelelo zePalmitoylethanolamide ekwandiseni impilo yengqondo zinxulunyaniswa namandla alo okulwa nosulelo lwe-neural kunye nokukhuthaza iiseli ze-neural zisinde. Oku kuqatshelwe ngakumbi kubantu abanengxaki yokuphazamiseka kwi-neurodegenerative and stroke.

Umzekelo, kuphononongo lwabantu abangama-250 abaphethwe sistroke, isongezelelo se-palmitoylethanolamide esilawulwa kunye ne-luteolin safunyanwa sinyusa ukubuyela kwimeko yesiqhelo. I-PEA yafunyanwa ukuphucula imemori, impilo yengqondo ngokubanzi kunye nokusebenza kwemihla ngemihla. Ezi ziphumo ze-palmitoylethanolamide powder zaqatshelwa kwiintsuku ezingama-30 emva kokuxhaswa kwaye zonyuka ngaphezulu kwenyanga enye.

 

ii. Ukunciphisa iintlungu ezininzi kunye nokuvuvukala

Iinzululwazi zibonelela ubungqina obuqaphelekayo bezinto zentlungu yesundu. Njengombandela wenyani, i-Palmitoylethanolamide ibonelela ngoncedo lweentlungu kwiintlobo ezahlukeneyo zentlungu kunye nosulelo. Olunye uphando olubonisa iiprophathi zentlungu ye-Palmitoylethanolamide;

Kwisifundo esichaphazela izilwanyana, isongezelelo sepalmitoylethanolamide Kunye nequercetin kwafunyanwa ukubonelela ngoncedo lwentlungu edibeneyo kunye nokuphucula ukusebenza ngokudibeneyo kunye nokukhusela intlala yomonakalo.

Olunye uphando lwaphambi kokubonisa lubonisa ukuba i-PEA inokunceda ukunciphisa iintlungu kwizifo zeswekile (isifo seswekile).

Kolunye uphononongo kunye nabantu abayi-12, umthamo we-Palmitoylethanolamide engama-300 kunye ne-1,200 mg / ngosuku olunikwe malunga neeveki ezintathu ukuya kwezi-3 wafunyanwa unciphisa ubukhulu beentlungu ezingapheliyo kunye ne-neuropathic.

Uphononongo lwezigulana ezingama-80 ezine-Fibromyalgia syndrome zifumanise ukuba i-PEA ukongeza kwamanye amayeza okuba nesifo esinganyangekiyo yehlise iintlungu.

Ukuqhubela phambili, ezinye izifundo ezininzi zibonisa i-Palmitoylethanolamide yeentlungu zokunceda ekubandezelweni kwentlungu kubandakanya ukubekeka kwintlungu ye-pelvic, kubuhlungu besayensi, kubuhlungu umva, kubuhlungu ngomhlaza phakathi kwabanye.

 

iii. Inceda ukunciphisa iimpawu zoxinzelelo

I-PEA ngokungathanga ngqo ichaphazela ii-receptors ezinoxanduva lwemood. Olunye uphononongo lubonisa ukukhululeka koxinzelelo njenge-palmitoylethanolamide njengeyona ndima iphambili ekulweni nokudakumba.

Kuphononongo lwezigulana ezingama-58 ezinoxinzelelo, isongezelelo se-Palmitoylethanolamide ngo-1200 mg / ngosuku kunye namayeza antidepressant (citalopram) esilawulwa iiveki ezi-6 kwafunyanwa ukuphucula imeko kunye neempawu zoxinzelelo ngokubanzi.

 

iv. Kuphelisa ingqele eqhelekileyo

I-Palmitoylethanolamide izibonelelo ekuchaseni ubuxoki obuqhelekileyo bokukwazi kwayo ukutshabalalisa intsholongwane enoxanduva lomkhuhlane oqhelekileyo (intsholongwane yomkhuhlane). Kuyamangalisa ukuba, ukubanda okuqhelekileyo kwenzeka ngokubanzi kwaye kuchaphazela phantse wonke umntu ngakumbi abantu abanezifo zokuzikhusela.

Uphononongo kunye namajoni aselula angama-900 abonise ukuba ithamo le-Palmitoylethanolamide ye-1200 mg ngosuku linciphisa ixesha elithatyathwe ngumntu obandakanyekayo ukuba aphilise ebusika kwaye neempawu ezinjengeentloko ebuhlungu, umkhuhlane kunye nomqala obuhlungu.

I-Palmitoylethanolamide (PEA)

v. Ukunciphisa iimpawu ze-insular (multiple) sclerosis

Ngepropitoylethanolamide eqinisekisiweyo yeepropathi ezichasene nokuvuvukala, i-PEA ngokungathandabuzekiyo ilungele ukunyanga i-sclerosis emininzi.

Kuphononongo lwezigulana ezingama-29 ezazineengxaki ezininzi zesifo sokuqina, i-PEA yongezwa kwi-standard standard ye-interferon IFN-β1a kwafunyanwa ukunciphisa ulusu kunye nokuphucula umgangatho wobomi bezigulana.

 

vi. I-Palmitoylethanolamide iphucula imetabolism

I-Palmitoylethanolamide (i-PEA) iyakwazi ukubopha kwi-PPAR- α, i-receptor ejongene nemetabolism, ukutya, ukunciphisa umzimba kunye namafutha avuthayo. Xa i-PPAR- α i-receptor ichukunyisiwe ufumana amanqanaba aphezulu amandla anceda umzimba ukuba utshise amafutha ngakumbi kwimithambo ngenxa yoko wehla emzimbeni.

 

vii. IPalmitoylethanolamide inokuwunciphisa umdla wakho wokutya

I-Palmitoylethanolamide yokulahleka kwesisindo ebonakalayo ibonakaliswa kumandla ayo okuphembelela kukutya. Kuyafana nokwandisa imetabolism, xa i-PPAR- α receptor icushiwe ikhokelela kwimvakalelo yokugcwala ngelixa usitya ngaloo ndlela kukunceda ukulawula inani leekhalori ezisetyenzisiweyo.

Ukongeza, i-PEA ithathwa njenge-acid ethanolamides edlala indima ephambili kwindlela yokuziphatha yokondla. Kuphononongo lwamagundwane athengwe kakhulu ngenxa yokufumana ubunzima obukhulu, isongezelelo se-PEA kwisisindo somzimba esingu-30 mg / kg kwiiveki ezi-5 kwafunyaniswa ukuba sehlise kakhulu ukutya kwabo, ubunzima bamafutha kwaye ngenxa yoko ubunzima bomzimba.

 

viii. Iimpembelelo ze-Palmitoylethanolamide ezichasayo xa uzilolonga

Umntu unokufumana iintlungu kunye nokudumba ngexesha nasemva kokusebenza ngenxa yobunzima obugqithisileyo. Ewe, ukongezwa kwe-PEA kunokukunceda ukukhusela oku ngokukhuthaza umsebenzi onxamnye nokuvuvukala we-PPAR- α receptor. I-Palmitoylethanolamide inokuthintela ukukhutshwa kwee-enzymes ezivuthayo kwizicubu zomntu.

 

Ngubani ofanele athathe isongezelelo sePalmitoylethanolamide (PEA)?

Isongezelelo sePalmitoylethanolamide (i-PEA) kufanelekile kubo bonke abaphethwe ziintlungu ezichasayo okanye ukuqaqanjelwa kwaye nabani na onomdla wokulahleka kwesisindo nokuba ngonyango okanye akunjalo. I-PEA iye yabonwa ikhulisa ukusebenza kwamanye amachiza. Ikhetho labo abangafumani mpumuzo ekusebenziseni ukubulawa kwentlungu emiselweyo.

Ukukhululeka koxinzelelo lwePalmitoylethanolamide luphawu olugqwesileyo nakubani na osemngciphekweni woxinzelelo okanye onesifo sokudakumba kufuneka athathe i-PEA.

Ngapha koko, omnye uya kuvuna ngaphezulu kwe-PEA kwizongezelelo kuba abavelisi bafuna ukwakhiwa okunyusa i-Palmitoylethanolamide bioavailability emzimbeni wakho.

 

Ivela phi iPea?

I-PeA yenziwe ngokwemvelo kwimizimba yethu nakwizilwanyana nakwizityalo. Nangona kunjalo, kubantu abaneentlungu ezingapheliyo okanye ukuvuvukala, i-PEA yenzeka ngokungalingani ngenxa yoko imfuno yezongezelelo ze-PEA.

IPalmitoylethanolamide inokufumaneka kwimithombo yokutya etyebile kwiiproteni ezinje ngobisi, inyama, iimbotyi zesoya, i-lecithin yesoya, amandongomane kunye nee-ertyisi zegadi phakathi kwezinye. Nangona kunjalo, i-PEA efunyenwe kwimithombo yokutya ngamanani amancinci. Oku kwenza i-palmitoylethanolamide yemveliso yesambuku eyimfuneko ukuhlangabezana neemfuno zokutya.

 

Ngaba i-PEA ikuphakamisa?

I-Phenethylamine kunye nePalmitoylethanolamide bobabini banokubiza i-PEA, kodwa iimveliso ezahlukileyo ngokupheleleyo.

I-Phenethylamine (i-PEA) yindawo ye-organic, i-monoamine alkaloid yendalo, kunye nokulandela umkhondo we-amine, esebenza njengenkqubo ye-nervous system evuselelayo ebantwini. I-Phenethylamine ivuselela umzimba ukuba wenze iikhemikhali ezithile ezidlala indima kuxinzelelo nakwezinye iimeko zengqondo.

Ithathiwe kumthamo we-500mg-1.5g ngedosi, rhoqo kwiiyure ezimbalwa, i-PEA ibonelela umsebenzisi ngemvakalelo yovuyo, amandla, ukhuthazo, kunye nokuba sempilweni ngokupheleleyo.

Nangona kunjalo, nceda uqaphele ukuba iPhenethylamine (PEA) ayisiyiPalmitoylethanolamide (PEA). Izongezo zePhenethylamine azange zamkelwe yi-FDA kusetyenziso lonyango. I-Palmitoylethanolamide (i-PEA) yinto yendalo eveliswa ngumzimba; iyasebenza kakhulu kwaye ikhuselekile ukuyisebenzisa njengesongezelelo seentlungu kunye nokudumba.

 

Ngaba i-PEA isongezelelo sikhuselekile?

I-Palmitoylethanolamide (i-PEA) yinto yendalo eveliswa ngumzimba; iyasebenza kakhulu kwaye ikhuselekile ukuyisebenzisa njengesongezelelo seentlungu kunye nokudumba. Akukho ziphumo zingalunganga ze-palmitoylethanolamide ezichaziweyo kunye nokungabikho konxibelelwano olubi nezinye iziyobisi.

 

Zithini iziphumo ebezingalindelekanga ze-PEA?

Akukho ziphumo ebezingalindelekanga ezibi okanye ukusebenzisana kweziyobisi kuye kwaxelwa ukuza kuthi ga ngoku. I-Palmitoylethanolamide inokuthathwa kunye nayo nayiphi na enye into. Ikonyusa isiphumo sokunciphisa iintlungu kwii-analgesics zakudala kunye ne-anti-inflammatories.

 

Ngaba iPalmitoylethanolamide ikhuselekile ekukhulelweni?

Ayinakusetyenziswa ngabafazi abakhulelweyo.

I-Palmitoylethanolamide inokukunceda ekujonganeni nokuvuvukala kunye nentlungu engapheliyo.

Kufuneka kuthathwe kuphela phantsi kolawulo lwezonyango.

 

IPalmitoylethanolamide ubomi obulicla - Ithatha ixesha elingakanani ipea ukuba isebenze?

I-Palmitoylethanolamide (i-PEA) inokuthathwa kunye namanye amayeza eentlungu okanye iyodwa, njengoko kucetyiswa yingcali yakho yokhathalelo lwempilo, ukuxhasa ukukhululeka kwentlungu.

Ukusebenza kokuthomalalisa iintlungu yi-8 hr

Iziphumo ziyahluka; iziphumo ngaphakathi kwe-48 hr kwabanye abantu, kodwa sebenzisa iiveki ze-8 kwiziphumo eziphezulu, inokusetyenziswa ixesha elide kwintlungu engapheliyo ye-neurological.

 

I-PEA isebenza njani ngeentlungu?

Uphando lubonakalisile ukuba i-PEA inezinto ezichasayo kunye nokuthintela ukunganyangi kwaye ukuyithatha rhoqo kunokunyusa impendulo yendalo yomzimba kwiintlungu ngokunciphisa impendulo yeeseli zenkqubo yeemvakalelo ezibangela iintlungu.

IPalmitoylethanolamide Ikwasebenza ngokungathanga ngqo ukwenza imisebenzi yezinye ii-receptors ezinje ngee-cannabinoid receptors. I-PEA ngokungathanga ngqo ivuselela ii-cannabinoid receptors (i-CB1 kunye ne-CB2) ngokusebenza njenge-enzyme (i-FAAH -fatty acid amide hydrolase) ebandakanyeka ekonakaleni kwe-cannabinoid anandamide. Olu ncedo ekukhuliseni amanqanaba e-anandamide kwimizimba yethu, enoxanduva lokuphumla kunye nokulwa nentlungu.

 

Yintoni i-PEA yokuphucula iintlungu?

I-Palmitoylethanolamide (i-PEA) yinto yendalo eveliswa ngumzimba; yi-asidi ye-fatty acid engapheliyo, eyiklasi ye-agonists yenyukliya, kwaye inokusetyenziselwa ukongeza unyango kunye nonyango lokudumba. I-PEA yimolekyuli yendalo, ekhuselayo, nenamafutha eveliswa emzimbeni wethu, inceda ukuxhasa i-myelin nerve sheaths yokusebenza kakuhle kwentliziyo.

I-PEA yi-asidi enamanqatha ebandakanyeka kwimisebenzi eyahlukeneyo yeselula ngokudumba kunye nentlungu engapheliyo, kwaye ibonakalisiwe ukuba ine-neuroprotective, anti-inflammatory, anti-nociceptive (anti-pain) kunye neepropathi ezichasayo. Iyanciphisa ukuhambisa kwesisu kunye nokwanda kweseli yomhlaza, kunye nokukhusela i-endothelium ye-vascular kwintliziyo yeschemic. Rhoqo kubantu abaneengxaki ezingapheliyo, umzimba awuyivelisi ngokwaneleyo i-PEA, yiyo loo nto ngokuthatha i-PEA ukongeza ukunqongophala komzimba kunokuba luncedo ekunyangeni le meko.

 

Ngaba i-Pea yinto echasayo?

I-Palmitoylethanolamide (i-PEA) yinto enomdla yokuthintela ukuvuvukala kwaye inokubamba isithembiso esikhulu kunyango lwe (auto) ukuphazamiseka komzimba, kubandakanya isifo samathumbu kunye nezifo ezivuthayo ze-CNS.

 

Ngaba ipea ilungile kwiarthritis?

I-Palmitoylethanolamide (i-PEA) ibonelela ngesibonelelo samathambo ngokubhekisele ekunciphiseni ukukhula kunye nokugcinwa kweentlungu ezingapheliyo kodwa kunye nokunceda ukunciphisa umda kwinkqubela yokutshatyalaliswa ngokudibeneyo okunxulumene nesifo samathambo.

 

Zeziphi ezona ntlungu zibalaseleyo zentlungu?

I-PEA (i-palmitoylethanolamide) ibikhona ukusukela nge-1970's kodwa ifumana igama njengearhente entsha ekunyangeni ukuvuvukala kunye nentlungu. Akukho nxibelelaniso lweziyobisi okanye isiphumo esibi esichongiweyo.

I-PEA ibonakalise ukusebenza kweentlungu ezingapheliyo zeentlobo ezininzi ezinxulunyaniswa neemeko ezininzi ezibuhlungu, ngakumbi iintlungu ze-neuropathic (nerve), iintlungu ezivuthayo kunye nentlungu ye-visceral efana ne-endometriosis kunye ne-cystitis yangaphakathi.

 

Ndingazinyanga njani iintlungu zemithambo-luvo ekhaya?

I-PEA yimolekyuli enamafutha enceda ukuxhasa i-myelin nerve sheaths yokusebenza kakuhle kwentliziyo.

Ukunqongophala kweevithamini ezivela kwiqela B akunokubangela iintlungu zentliziyo kuphela, kodwa kuyonyusa.

Iimpawu ezongezelelekileyo ezingathandekiyo zinokubakho, ezinjengokugungqa, ukurhawuzelela nokuhlaba izandla neenyawo, ukuziva ngathi umntu uhamba ngocingo oluhlabayo okanye uboya bekotoni okanye nokuba ndindisholo

izandla neenyawo.

Uvithamini B1 omncinci kakhulu ukhokelela kukuphazamiseka ekusebenzeni kwemithambo-luvo kwaye ngenxa yoko kwi-neuropathy kunye neentlungu zentliziyo. Xa usongeza ivithamini B1, iintlungu ziyancipha kwaye ukusebenza kwentliziyo kuyaphucuka. I-Vitamin B1 inokuthathwa kunye ne-PEA, oku kubonelela ngenkxaso efanelekileyo ekusebenzeni kwemithambo-luvo, kuthintela iintlungu zentliziyo okanye iintlungu eziba mandundu. Izifundo zamva nje zibonise ukuba abantu abaninzi abaneentlungu ezingapheliyo, abantu abadala kunye nesifo seswekile abaneli ngokwaneleyo kwezi vithamini egazini labo. Esi sesinye sezizathu zokuba aba bantu abanakunyangwa kuphela ziipilisi zeentlungu; bayazidinga

ngaphezulu koko. Iivithamini ze-PEA kunye ne-B zixhasa iinkqubo zemithambo-luvo kunye namajoni omzimba kwimeko yeentlungu.

 

I-Palmitoylethanolamide (PEA)

Ngaba i-Palmitoylethanolamide yi-cannabinoid?

I-CBD (i-Cannabidiol) ziikhompawundi ezikhutshwe kwi-hemp nakwintsangu. Ngelixa umzimba uvelisa i-cannabinoids ngokwemvelo, i-CBD iye yongezwa ukuze ifezekise isidingo.

IiCannabinoids ziikhemikhali ezisebenzayo zebhayoloji eziveliswa emzimbeni ezinoxanduva lokukhumbula, iintlungu, ukutya, kunye nokunyakaza. Izazinzulu ziqikelela ukuba i-cannabinoids inokuba luncedo ekunciphiseni ukuvuvukala kunye noxinzelelo, ukutshabalalisa iiseli zomhlaza, ukubonelela ngokuphumla kwezihlunu kunye nokukhulisa umdla.

I-PEA yi-acid amide ene-amide ekwaveliswa emzimbeni kwaye ingabizwa ngokuba yi-cannabimimetic. Oku kuthetha ukuba kulingisa imisebenzi ye-CBD emzimbeni wakho.

Zombini i-CBD kunye ne-PEA zisebenza ngokungangqalanga ngokuthintela i-acid acid i-amide hydrolase (FAAH), edla ngokwaphula i-anandamide kwaye iyenze buthathaka. Oku kubangela amanqanaba aphezulu e-anandamide. Anandamide idlala indima enkulu kwiimvakalelo kunye nenkuthazo. Amanqanaba anyukayo e-anandamide anempembelelo entle kwinkqubo ye-endocannabinoid.

I-PEA ifumene ukuthandwa kwaye ikhuphisana ne-CBD. I-PEA ithathwa njengeyona ndlela ikhuselekileyo ye-CBD ngenxa yemicimbi yezomthetho ejongene nayo kunye nenyaniso yokuba uninzi lwabantu alunakuwanyamezela amanqanaba aphezulu 'elitye' eliza ne-CBD.

Ukongeza, i-PEA ibiza kakhulu kune-CBD. Nangona kunjalo, i-PEA ingasetyenziselwa ukongeza kwi-CBD ukufezekisa iziphumo ze-synergetic.

 

Ngaba i-Pea yi-endocannabinoid?

Hayi, iPalmitoylethanolamide (i-PEA) yi-endocannabinoid-efana ne-lipid mediator eneempawu ze-analgesic kunye ne-anti-inflammatory. I-PEA ixhasa i-ECS ngokumodareyitha i-endocannabinoid signaling kunye ngokungathanga ngqo isebenze i-cannabinoid receptors.

Inkqubo ye-endocannabinoid (ECS) yinkqubo ebalulekileyo yebhayiloji elawula kunye nokulinganisa uluhlu olubanzi lwemisebenzi yomzimba emzimbeni. Uphando kwi-ECS lukhokelele ekuchongweni kwe-endocannabinoids kungekuphela kwe-anandamide (AEA) kunye ne-2-arachidonoylglycerol (2-AG), kodwa kunye ne-endocannabinoid-like lipid mediators ezifana ne-palmitoylethanolamide (PEA). Ezi endocannabinoid-ezinje ngezihlanganisi zihlala zabelana ngeendlela ezifanayo ze-endocannabinoids kodwa zinqongophele kubumbano lodidi lwe-cannabinoid receptor 1 kunye nohlobo 2 (CB1 kunye ne-CB2).

 

I-Palmitoylethanolamide (i-PEA) kunye ne-Anandamide

I-Palmitoylethanolamide kunye ne-anandamide zihambelana ngokusondeleyo kuba bobabini bangama-acid amide amayeza aveliswe emzimbeni.

I-PEA kunye ne-anandamide kuthiwa baneziphumo ezihambelanayo kunyango lwentlungu kwaye zonyusa ababulali abasetyenzisiweyo.

Ukwahlulwa yi-enzyme enamafutha acid emzimbeni, ngenxa yoko iziphumo ezifezekiswayo xa zisetyenziswa kunye zingaphezu kokuba zisetyenziswa kwisongezo esimileyo.

 

I-Palmitoylethanolamide VS Phenylethylamine

I-Phenethylamine yinto enekhemikhali eveliswa ngumzimba. Isetyenziselwa ngokubanzi ukuphucula ukusebenza kwimbaleki kwaye inokunceda ukunciphisa ukudakumba, uncedo ekunciphiseni ubunzima kunye nokuphucula imeko.

I-Palmitoylethanolamide kwelinye icala yi-acid amide eyaziwa ngokuba yintlungu kunye nosizi lokuvuvukala.

Ezi zidityaniso zimbini azidibananga. Into kuphela ebadibanisayo kukuba bobabini banokufinyezwa njenge-PEA.

 

Ndisithatha njani isongezelelo sePalmitoylethanolamide (PEA)?

Ngelixa sigxininise kwinzuzo yokulwa nokuvuvukala yesundu phakathi kweenzuzo, kufanelekile ukuba nizise ezinye iinyani malunga ne-PEA. I-PEA yenzeka kumasuntswana amakhulu kwaye ingafakwanga manzi, oku kwenza ukuba i-Palmitoylethanolamide ibe bioavailability kunye nokungeniswa.

Iindaba ezimnandi, nangona kunjalo, kukuba abavelisi bajolise kwiimpawu ezenza ukuba kusebenze i-Palmitoylethanolamide bioavailability yokusetyenziswa okuphezulu komzimba wakho. Ezi, Umgubo we-PEA ziyafumaneka kwifom yomgubo oqhelekileyo kunye nefom micromised powder form.

 

Kuphi ukuthenga iPalmitoylethanolamide (PEA) ipowder?

Sikwixesha elinomdla apho iivenkile ezikwi-Intanethi ziye zaba yivenkile yokumisa yonke into kubandakanya i-palmitoylethanolamide yesambuku sonikezelo. Ukuba ucinga ukuthatha i-PEA, uphando ngokubanzi kubenzi be-legititoylethanolamide yesongezelelo sabenzi. Uninzi lwabasebenzisi be-palmitoylethanolamide bayithenga kwiivenkile ezikwi-Intanethi kwaye kufuneka baqwalasele uphononongo lwabo lweyona powder ilungileyo ye-PEA kwintengiso.

 

izifinyezo

I-AEA: Anandamide

CB1: Uhlobo lwe-Cannabinoid I-receptor

I-CB2: I-Cannabinoid yohlobo lwe-II receptor

I-CENTRAL: IRejista yeCochrane esembindini yezilingo ezilawulwayo

I-FAAH: I-fatty-acid amide hydrolase

NAAA: N-acylethanolamine hydrolyzing acid amidase

NAE: N-acylethanolamines

I-PEA: IPalmitoylethanolamid

I-PPARα: I-Peroxisome proliferator-activated receptor alpha

I-PRISMA-P: Izinto ezikhethiweyo zeNgxelo yoPhononongo olucwangcisiweyo kunye neMigaqo yoHlahlelo lweMeta

Intlungu ye-VAS: Isikali seAnalogical yeNtlungu

ECS: inkqubo ye-endocannabinoid

 

Imbekiselo:

[1] UArtukoglu BB, uBeyer C, uZuloff-Shani A, et al. Ukusebenza kwepalmitoylethanolamide yeentlungu: Uhlalutyo lweemeta. Ugqirha wezinhlungu 2017; 20 (5): 353-362.

[2] USchifilliti C, uCucinotta L, uFedele V, et al. Micronized palmitoylethanolamide inciphisa iimpawu zentlungu ye-neuropathic kwizigulana ezinesifo seswekile. Ukunyangwa kwePain 2014; 2014: 849623.

[3] UKeppel Hasselink JM, uHekker TA. Unyango olusebenzayo lonyango lwe-palmitoylethanolamide kunyango lwentlungu ye-neuropathic enxulunyaniswa neemeko ezahlukeneyo zophendlo lwezifo: uthotho lwamatyala. I-J Pain Res 2012; 5: 437-442.

[4] UKeppel Hasselink JM, uKopsky DJ. Indima ye-palmitoylethanolamide, i-autacoid, kunyango lweempawu zeekram zesisipha: iingxelo zamatyala amathathu kunye nokuphononongwa koncwadi. J Iklinikhi yokuPhendula ngo-2016; 6 (3).

[5] ICosta B, iColombo A, iBettoni I, iBresciani E, iTorsello A, uComelli F. I-ligand palmitoylethanolamide ye-endo native igxotha iintlungu ze-neuropathic ngokusebenzisa i-mast cell kunye ne-microglia modulation. I-21st Symposium yoNyaka yoMbutho woPhando we-Cannabinoid wamanye amazwe. I-St. Charles, Il. Usa: Ukubaleka kwePheasant; Ngo-2011.

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