I-L - (+) -I-Ergothioneine (i-EGT) (497-30-3)

Matshi 15, 2020
SKU: 1010396-29-8
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Ergothioneine yinto yemvelo evela kwi-amino acid kwaye isuselwa kwimbali ye-histidine, equkethe i-atom yesalfure kwi …………… ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

L - (+) - ividiyo ye-Ergothioneine (EGT) (497-30-3) ividiyo

L - (+) - I-Ergothioneine (EGT) powder Suqobo

Igama lemveliso L - (+) - I-Ergothioneine (EGT)
Igama leKhemikhali I-ERGOTHIONEINE;

L-Ergothioneine;

I-Sympectothion;

l ergothioneine

uhlobo Numama N / A
Iqela leziyobisi N / A
Inani leCAS 497-30-3
InChIKey I-SSISHJJTAXXQAX-ZETCQYMHSA-N
I molecular Fi-ormula C9H15N3O2S
I molecular WSibhozo 229.3 g / mol
IMasaisotopic Mass 229.088498 g / mol
Indawo yokubilisa N / A
Fukuhlaziywa kwakhona Point N / A
I-Biological Half-Life N / A
umbala Omhlophe okanye ongenawo omhlophe
Sukufaneleka Ukunyibilika emanzini (ukuya kuthi ga kwi-10 mg / ml)
Sisibetho Tukushisa -20 ° C
Aukuguquka l ergothioneine powder uyisebenzise kwizongezo ezisempilweni

L - (+) -I-Ergothioneine (EGT) (497-30-3) Isishwankathelo

I-Ergothioneine yinto yemvelo evela kwi-amino acid kwaye ithathwa njenge-histouine ye-histidine, equkethe i-atom yesalfa kwindandatho ye-imidazole. Le khompawundi yenziwe kwizinto ezimbalwa eziphilayo, ngokukodwa i-Actinobacteria, Cyanobacteria, kunye nesikhunta esithile. I-Ergothioneine ifuna umthuthi othile, i-EGT, ekwabizwa ngokuba yi-OCTN1 (isimboli yemfuza SLC22A4), ukufaka iiseli. Ukuchazwa kwe-EGT kuqinisekisiwe kwimigca yeseli yabantu kunye nezilwanyana kunye nokusebenza kwazo ukuthutha i-ergothioneine kuqinisekisiwe kwi-vivo.

I-L-ergothioneine yenzeka ngokwendalo i-amino acid kwaye ithathwa njenge-thiol / thione ye-histidine. I-L-ergothioneine ifumaneka kweyona ndawo kugxilwe kuyo amakhowa kunye neebhaktheriya nakwizinga eliphantsi lokunye ukutya kubandakanya inkosi ibrab, inyama yenyama, inyama yengulube, imvana kunye nenkukhu.

Ngaphandle kobukho be-L-ergothioneine kukutya okutyiwa ngabantu, i-biosynthesis yayo ibonwe kuphela kwiibhaktheriya ezithile kunye nefungi.

Yintoni i L - (+) - I-Ergothioneine (EGT) ?

I-L-Ergothioneine yi-amino acid efumaneka ikakhulu kumakhowa, kodwa nakwi-king crab, inyama evela kwizilwanyana ezitya utyani obune-ergothioneine, kunye nokunye ukutya. I-Amino acids ziikhemikhali eziyindawo yokwakha iiprotein. I-Ergothioneine isetyenziswa njengeyeza.

Abantu bathatha i-ergothioneine yomonakalo wesibindi, ikati, isifo se-Alzheimer, isifo seswekile, kunye nesifo sentliziyo.

I-L - (+) - i-ERGOTHIO yintsholongwane yendalo ye-antioxidant ye-chiral yendalo kwi-bacteria kunye nefungi. Yicandelo elibalulekileyo le-biioactive esetyenziswe njenge-scavenger egqibeleleyo, isihluzi se-ray ye-Ultraviolet, isilawuli seempembelelo zokunciphisa ukuncitshiswa kwe-oxidation kunye ne-cellular bioenergetics, kunye ne-cytoprotector ye-physiological, njl.

I-L-Ergothioneine ngamanye amaxesha ifakwa ngqo esikhumbeni ukukhusela imibimbi, ukunciphisa iimpawu zesikhumba sokuguga, kunye nokunciphisa ukonakala kwelanga.

L - (+) - Izibonelelo ze-Ergothioneine (EGT)

I-L-ergothioneine ikhethekile kuba inokuthi ifike kubunzulu beeseli ezithile ezinjenge-erythrocyte, ngokungafaniyo nezinye izinto zakudala ezinje ngeevithamini C no-E. Inesifo esineempawu zeproteyini yothwala, ezenza ukuba zithathwe zilungile Intliziyo yeeseli. Yiyo ke inokubangela i-antioxidant enobuthathaka obunamandla, njenge-L-glutathione. Ukongeza, ikwabonakalisiwe njengeyona chelator inamandla, iyenza ukuba ibophele kwizinyithi ezinetyhefu, ngelixa ikhusela iiseli zegazi kuzo zonke iintlobo zomonakalo.

Kukhuthazwe iipropathi zayo ze-antioxidant, abaphandi baphanda kamva ngefuthe layo lokuchasana nokuvuvukala, kuba i-ergothioneine isebenza, phakathi kwabanye, i-cytokine ye-pro-immune, i-interleukin. I-L - (+) -I-Ergothioneine (i-EGT) ineempawu ezininzi ezisebenzayo ngaphakathi komzimba womntu:

  • Iguqula iimolekyuli ze-oksijini ezisebenzayo (ii-radicals zasimahla), ke ngoko kuxhathise uxinzelelo lwe-oxidative kunye nokunciphisa umonakalo kwi-DNA ye-mitochondrial, oxidation yeeproteni kunye ne-lipid peroxidation;
  • I-Chelates - okanye izicupho - ezahlukeneyo zentsimbi;
  • Ngaba unokusebenzisa ii-enzymes ze-antioxidant ezifana ne-glutathione peroxidase okanye i-SOD, ngelixa uthintela i-enzymes ezivelisa i-superoxide radical;
  • Iyancipha i-oxidation yee-haemoprotein ezahlukeneyo ezinjenge-hemoglobin kunye ne-myoglobin;
  • Ukukhusela i-mitochondria;
  • I-L-ergothioneinereduces enobungozi kwimisebe ye-UV, njenge-arhente yokhuselo kuKhathalelo loLusu.
  • Gcina kwaye ugcine amanqanaba ezinye i-antioxidants ezifana neevithamini C kunye no-E, glutathione kunye neSOD;
  • Ukukhusela ubuchopho kwii-neurotoxins kwaye ke oko kudlala indima yokuthintela ekunciphiseni kwengqondo;
  • Ikhuthaza ukuphefumla kweselula kunye ne-lipolysis enamafutha, ke oko kukongeza amandla kunye namandla amandla okuzivocavoca;
  • Xa zidityaniswa kunye hyaluronic acid, glucosamine, collagen, yaboniswa ukunciphisa kakhulu iintlungu ngokudibeneyo kunye nokunyusa ukuhamba okuhlanganisiweyo, okunxulunyaniswa ikakhulu nemikhwa emibi yokusebenza yasemva, emva kokusetyenziswa nje kweeveki ezintandathu.

L - (+) - I-Ergothioneine (EGT) yokhuseleko

Nangona i-l-ergothioneine yabelana ngegama kwaye inokuthi ivele kwi-ergot fungus, ayiyongozi nangayiphi na indlela.

I-European Union inemigangatho yokuxhasa eyomeleleyo kune-United States kwaye igqibe ekubeni izongezo ze-l-ergothioneine zikhuselekile kwaye azivelisi miphumo mibi kubantu abadala nakubantwana ngaphezulu.

Iphaneli yeeMveliso zeDietetic zeGunya loKhuseleko loKutya laseYurophu ifumanisa ukuba imida ekhuselekileyo yemihla ngemihla ye-2.82 mg / kg ubunzima bomzimba wabasana, i-3.39 mg / kg yabantwana abancinci, kunye ne-1.31 mg / kg yabantu abadala, kubandakanya abasetyhini abakhulelweyo nabancancisayo.

I-L - (+) - i-Ergothioneine (EGT) umgubo setyenziso kunye nesicelo

Ukongezwa ngokufanelekileyo kunye / okanye ukutya okuphuculweyo kubandakanya iivithamini zobude obude njenge-L-ergothioneine eyongeziweyo inokunciphisa umngcipheko omkhulu wesifo esingapheliyo kunye nokuguga ngaphambi kwexesha.

I-L-ergothioneine powder sisithako esifanelekileyo sokwaluphala okunempilo, ifomula yesondlo.

Uphando lucebisa ukuba imisebenzi ene-EGT ye-antioxidant inokubakho njenge-anti-immune ukukhusela iiseli ngokuchasene nezifo zomzimba kunye ne-neurodegenerative.

  1. Ukuvutha

Uphando lubonisa ukuba njenge-antioxidant, i-EGT inokukhusela nxamnye nosulelo.

Isifo samathambo sisifo sokuphazamiseka kwemoto esibonakaliswe kukukrala okukhulu (kwaye kuhlala kungachazwanga).

Kungenzeka ukuba i-EGT inokunciphisa ukuvuvukala kwizigulana ezine-rheumatoid arthritis.

  1. Izifo ze-Neurodeergenerative

Njenge-cytoprotectant, i-EGT sisongezelelo esidumileyo phakathi kwabaguli baka-Alzheimer's kunye no-Parkinson.

I-EGT ixhasa inkqubo yemvelo yokuzikhusela ye-antioxidant yomzimba kwaye inokukhusela iiseli zengqondo kumonakalo we-oxidative kunye noxinzelelo kwi-radicals yasimahla.

Ngokukhusela iiseli zobuchopho, ukubonakala kwayo ukukhusela ukubulawa kweseli yobuchopho kwindawo yokuqala kunye nokukhusela kwizifo ze-neurodegenerative.

  1. Izifo zesifo

Ngombulelo kwi-cytoprotectant yayo kunye ne-antioxidant enokubakho, i-EGT yeyona nto iyithandayo i-amino acid kwizigulana ezinesifo sesibindi.

  1. Ukuchasana nokwaluphala kunokubakho

Uza kuyifumana rhoqo i-EGT kwiimveliso ezininzi ze-skincare ngenxa yeempawu zayo zecyptoprotectant kunye ne-antioxidant- ezinokukhusela iiseli zolusu kumonakalo oxid.

Umonakalo osimahla wamahhala kunye noxinzelelo lwe-oxidative luncedo oluphambili ekugugeni ngaphambi kwexesha, ulusu olujiyileyo, kunye nemibimbi.

  1. Izifo eziLuphele

ISebe lezoKhuselo lase-US linikezele ngesibonelelo sezigidi zeedola ezisisi-1.34 sezigidi kubaphandi kwiYunivesithi yaseColorado ukuba basebenzise isenzo se-antioxidant se-EGT sokulwa nezifo zemiphunga xa kulwelwa amagqala.

isingqiniso:

  • U-Oumari M, et al. Ukuvuselelwa ngokutsha kwe-ergothioneine emva kokusabela nge-oxygen. Isimahla iRadic Biol Med. I-2019 Aprili; 134: 498-504.
  • I-Cheah, i-LK, iHalliwell, iB. Ergothioneine; i-antioxidant enokubakho, umsebenzi womzimba kunye nendima yesifo, i-Biochim. Ii-biophys. Acta 2012; (5): 784-793.
  • UGenghof, iDiosynthesis ye-DS ye-Ergothioneine kunye neHercynine ngu. I-fungus kunye ne-Actinomycetales, uJ. Bacteriol., 1970; 103 (2): 475-478.
  • Ukuphendula kwakhona, i-JE, i-Elkins, i-ND Isiphumo se-ergothioneine ekonzakaleni kwamaphaphu okwenzakalisayo kunye nokukrala kwimigundane ye-cytokine engafakwanga, Prev. IMed. Ngo-2012; (54): S79-S82.
  • Iphaneli ye-EFSA kwiiMveliso zeDietetiki, iSondlo kunye neAlleries (2017). "Ingxelo malunga nokhuseleko lwe-l-ergothioneine njengokutya okutsha - ukuveza ukutya okongezelelekileyo kunye novavanyo lokhuselo kwiintsana nakubantwana abancinci, abakhulelweyo nabancancisayo". Ijenali ye-EFSA. I-15 (11): 5060. i-doi: 10.2903 / j.efsa.2017.5060.