I-Raw Caffeic acid i-phenethyl ester powder (104594-70-9)

Disemba 28, 2018
SKU: 104594-70-9
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Raw Caffeic acid i-phéethyl ester powder yi-phenethyl ester yotywala ye-caffeic acid kunye ne-bioactive ......


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1180kg / inyanga

I-Raw Caffeic acid i-phenethyl ester powder (104594-70-9) ividiyo

I-Raw Caffeic acid i-phenethyl ester powder (104594-70-9) Suqobo

Igama lemveliso I-Raw Caffeic acid i-phenethyl ester powder
Igama leKhemikhali I-Raw Caffeic acid i-phenethyl ester powder;

Caffeate; Cafethyl caffeate; I-Caffeic acid i-2-phenylethyl ester; i-β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

uhlobo Numama Akukho datha ekhoyo
Iqela leziyobisi Tyrosine Kinase Inhibitors, Inhibitors
Inani leCAS 104594-70-9
InChIKey SWUARLUWKZWEBQ-VQHVLOKHSA-N
I molecular Fi-ormula C17H16O4
I molecular WSibhozo 284.311 g / mol
IMasaisotopic Mass 284.31 g · mol-1
Ukuxuba Point I-125-126ºC (i-dec.)
Indawo yokubilisa 498.6 ± 45.0 ° C kwi-760 mmHg
I-Biological Half-Life Akukho Datha ekhoyo
umbala ngaphandel uBumhlophe
Sukufaneleka I-Soluble kwi-acetate ye-ethyl kwi-50mg / ml. I-Soluble kwi-DMSO kunye ne-ethanol.
Sisibetho Tukushisa Gcina kwi-0 ° C
I-Raw Caffeic acid i-phenethyl ester powder Aukuguquka I-agent ye-cytotoxic ngokubhekiselele kumgca wecala lomhlaza. Inhibitor ye-ornithine decarboxylase kunye neprotheni tyrosine kinase. Kufunyenwe ukuba yi-inhibitor ethile ye-nuclear-transcription factor, iNF-kB. Kuye kwaboniswa ukuba ikhuphe ngokunyanisekileyo indlela ye-lipoxygenase ye-arachidonic acid metabolism ngexesha lokuvuvukala.

I-Raw Caffeic acid i-phenethyl ester powder (104594-70-9) Inkcazelo

I-Raw Caffeic acid i-phéethyl ester powder yi-phenethyl ester yotywala ye-cafeic acid kunye ne-bioactive ye-honeybee hive propolis, kunye ne-antineoplastic, i-cytoprotective kunye ne-immunomodulating activities. Phezu kokulawulwa, iRaw Caffeic acid i-phenethyl ester powder (CAPE) inqanda ukusebenza kwe-NF-kappa B kunye ne-P70S6K kunye ne-Akt-driven path signaling pathways. Ukongezelela, i-CAPE inqanda i-PDGF-eyenza ukwanda kwamaseli e-muscular smooth muscle ngokusebenzisa i-proxy kinase (PKNUMX) ene-protein kinase (MAPK) kunye ne-hypoxia-inducible factor (HIF) -38alpha kunye nokufakelwa kwe-heme oxygenase-1 (HO-1) .

I-caffeic acid i-phenethyl ester ibikwa ukuba ine-anti-carcinogenic, anti-inflammatory, kunye ne-immunomodulatory properties. I-CAPE inqanda i-HIV-1 integrase. Iimpawu ezichasayo zicatshangelwe ukuba ngenxa yokunciphisa i-lipoxygenase endleleni ye-arachidonic acid metabolism yi-CAPE. Ucwaningo luye lwabonisa ukuba i-CAPE ibe yinto ekhethekileyo neyomeleleyo yokusebenza kwe-NF kappa B, yinto ephambili yeprotheni elawula ukubhalwa kwe-DNA. I-Caffeic Acid i-Phenethylester inhibitor ye-ODC kunye noTyrosine Kinase

I-Caffeic acid i-phenethyl ester powder (104594-70-9) Indlela yokusebenza

I-Caffeic acid i-phenethyl ester yinto ehamba phambili ye-propolis ye-honeybee hives, inqanda ukuqaliswa kwe-NF-κB eyenziwe ngu-phorbol ester, i-ceramide, i-okadaic acid kunye ne-peroxide ye-hydrogen ngokuthintela ukutshintshwa kwe-p65 subunit ye-NF-κB kwi-nucleus. Kuluhlu lwemizila yeselonda lesisu, i-Caffeic acid i-phenethyl ester ibonisa umsebenzi othembisayo onokuthi ungaphikisi kunye ne-EC50 ye-1.76, i-3.16, i-13.7, kunye ne-44.0 μM ngokumelene nekolon ye-murine 26-L5, i-murinoma ye-B16-BL6, i-HT-1080 fibrosarcoma kunye nomphunga womntu we-A549 imizila yeseli ye-adenocarcinoma, ngokulandelanayo. I-Caffeic acid i-phenethyl ester, njenge-antioxidant enamandla, inomphumela wayo wokulwa ne-apoptotic kwi-cerebellar granule cells ngokuthintela ukubunjwa kwe-ROS kunye nokuvimbela umsebenzi we-caspase. Ngaphezu koko, i-Caffeic acid i-phenethyl ester igxininisa i-phenotype engumlomo we-LPS-evuselelwe i-HSC, kunye nokukhutshwa kwe-LPS-ukukhutshulwa kwe-HSC kwii-cytokines ze-fibrogenic ngokuvimbela i-NF-κB ukubonisa.

Ku-vivo, i-Caffeic acid i-phenethyl ester (i-10 mg / kg, ip) inqanda ukukhula kunye ne-angiogenesis yezidumbu eziphambili kwi-C57BL / 6 kunye ne-BALB / c i-inoculated ne-Lewis lung carcinoma, i-colon carcinoma kunye neeseli ze-melanoma. I-Caffeic acid i-phenethyl ester (5, 10, 20 mg / kg) nayo ibonisa imiphumo ye-immunomodulatory in vivo ngokunciphisa ubunzima be-thymus kunye / okanye iselula ye-thymus kunye ne-spleen.

Ukusetyenziswa kwe-Caffeic acid i-phenethyl ester powder (104594-70-9)

▪ I-Antineoplastic

▪ Ukungabi naso

▪ Iimmunomodulator

▪ I-block yeNFkB

iinzuzo I-Caffeic acid i-phenethyl ester powder (104594-70-9)

I-caffeate ye-phhenethyl yinkomfa efumaneka kwipolisi, umxube oveliswa yizinyosi. I-Caffeic acid i-phenethyl ester (i-CAPE) inokusebenza ekukhuseleni nasekunyangeni izifo ezivuthayo eziquka i-rheumatoid arthritis, i-systemic lupus erythematosus kunye ne-psoriasis, iintlobo ezahlukeneyo zomhlaza kunye nezifo ezibandakanya ukubunjwa kwe-tumor, i-cataract, kunye nezinye izifo ezibangelwa ukuxinzezeleka kwengcinezelo. Ukongezelela, i-CAPE ingasetyenziselwa ukunyanga usulelo lwe-HIV xa lidibaniswe kunye nohlobo lwezilwanyana oluvimba ukuphindaphinda kwe-HIV. Ingasetyenziselwa ukulwa ne-atherosclerotic, antioxidative, cardioprotective, anti-fatness and antimitogenic.