I-Pyrroloquinoline quinone (PQQ) (72909-34-3)

Matshi 11, 2019
SKU: 108-09-8
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

IPyrroloquinoline quinone (PQQ), ekwabizwa ngokuba yi-methoxatin, yi-redox cofactor. Ifunyanwa emhlabeni nasekudleni njenge kiwifruit, njenge …………… ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

I-Pyrroloquinoline quinone (PQQ) (72909-34-3) ividiyo

I-Pyrroloquinoline quinone (PQQ) (72909-34-3) Iinkcukacha

Igama lemveliso Iprroloquinoline quinone (PQQ)
Igama leKhemikhali I-Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Inani leCAS 72909-34-3
InChIKey I-MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
I-Molecular Formula C14H6N2O8
Isisindo somzimba 330.21
IMasaisotopic Mass 330.012415 g / mol
Indawo yokujonga indawo 1018.6 ± 65.0 ° C (Kuxelwe kwangaphambili)
Indawo yokudanyaza I-569.8 ° C (1,057.6 ° F; 842.9 K)
mninzi 1.963 0.06 3 g / cmXNUMX (Kuxelwe kwangaphambili)
umbala I-Orange-Red Solid
Indawo yokugcina 2-8 ° C
Umzimba I-Soluble emanzini
isicelo I-PQQ iye yaxelwa ukuba isebenza njengevithamini enyibilikisa amanzi / i-cofactor kunye ne-antioxidant. Yenzelwe ukusetyenziselwa izongezo zokutya, njengamandla, ukutshintshwa kwesidlo, kunye nemivalo eyomeleleyo njl.

Yintoni i Iprroloquinoline quinone(PQQ)?

IPyrroloquinoline quinone (PQQ), ekwabizwa ngokuba yi-methoxatin, yi-redox cofactor. Ifunyanwa emhlabeni kunye nokutya okufana ne-kiwifruit, kunye nobisi lwebele lomntu. I-Pyrroloquinoline quinone yi-pyrroloquinoline enamaqela e-oxo kwizithuba ezi-4 ukuya kwezi-5 kunye namaqela e-carboxy kwiindawo ezi-2-, 7 - 9 kunye ne-XNUMX. Inendima njengevithamini enyibilikiswa ngamanzi kunye ne-cofactor. Kwaye, sisiginali esibonisa iiprotein kinases ezichaphazelekayo ekwahluleni kweeseli ezanyisayo. Amandla aphezulu okuphinda kusetyenziswe kwakhona i-PPQ inokunika indima ye-pharmacological ekukhuseleni ngokuchasene ne-neurodegeneration kunye nomhlaza. (Njenge-arhente ye-redox, iPyrroloquinoline quinone izinzile kakhulu kwaye inokuthatha inxaxheba kwiziphumo ezingamakhulu kunamanye ama-antioxidants, anjenge-ascorbic acid, quercetin, kunye ne-epicatechin.

I-Pyrroloquinoline quinone yi-biofactor yenoveli, kwaye yaqwalaselwa njenge-enzyme cofactor kwiibacteria. Uphando lubonisa ukuba i-Pyrroloquinoline quinone inokuba ibikho ngalo lonke ixesha loqwalaselo lwebhayoloji kunye nokuvela kwendalo. Njengenxalenye yesityalo esinamandla okukhula, ikhona ekukhuleni kwezilwanyana nabantu. I-Pyrroloquinoline quinone inikwe ingxelo yokuba ithathe inxaxheba kuluhlu lwemisebenzi yemvelo eneenzuzo ezibonakalayo zokuphila (umzekelo, ukukhula okuphuculweyo kwe-neonatal kunye nokuzala) kwizilwanyana.

Ngaphezu koko, i-Pyrroloquinoline quinone ine-antioxidant kunye ne-B-vitamin-efana nomsebenzi, onoluhlu olubanzi lwezibonelelo zobuchopho kunye nomzimba. Ikhuthaza impilo kunye nokukhumbula ngokulwa ukungasebenzi kakuhle kwe-mitochondrial kunye nokukhusela i-neurons kumonakalo we-oxidative. Izifundo zeklinikhi ebantwini zibonise ukuba iPyrroloquinoline quinone iphucula inkumbulo yexesha elifutshane kunye nokuqwalaselwa, ukuphucula amandla e-metabolism kunye nokuguga okunempilo, kunye nokunciphisa iimpawu zokuvuvukala, kunye nokuphucula ukuziva ngokubanzi kokuphila.

Yenzeka njani iPyrroloquinoline quinone(PQQ) ukusebenza?

Izifundo zamanqanaba zibonisa ukusebenza ngokubonakalayo kwePinroloquinoline quinone ekukhuthazeni i-mitochondrial biogeneis. Amanqanaba hepatocytes afakwe kwi-PQQ kwi-10-30 μM ye-24- 48 h ebonisiweyo "ukunyusa i-citrate synthase kunye nomsebenzi we-cytochrome c oxidase, ukubekwa kweMitotracker, umxholo we-mitochondrial ye-DNA, kunye nokuphefumla kwe-oxygen. Ukuqalwa kwale nkqubo kwenzeka ngokuvuselelwa kweprotheni yokuphendula ye-cAMP (CREB) kunye ne-peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), indlela eyaziwayo yokulawula i-mitochondrial biogenesis. Kwizifundo ze-vivo kwiigundane zikwabonisa nemiphumo eyingenelo evela kukutya okongeziweyo ngePQQ (2mg PQQ / kg yokutya). Oku kubandakanya ukunciphisa i-pligma triglycerides, ukunyusa inkcitho kwamandla (kudityaniswa nomxholo we-hepatic mitochondrial), kunye nokunyamezelana kokunyamezelana kwentliziyo kunye ne-repicfusion yentliziyo. Iimodeli zovavanyo zokubetha kunye nokulimala kwentambo yomgogodla zibonisa ukuba iPyrroloquinoline quinone ifumanisa ukubulawa kweseli ye-neuronal, ngokwenxalenye ye-Pyrroloquinoline quinone ekhusela ii-receptors ze-N-methyl-d-aspartic acid (NMDA). Iimodeli zerhasi yesifo sikaParkinson zibonisa ukuba iPrincoloquinoline quinone isongezelelo inciphisa ilahleko ye-neuronal, inyusa amandla e-oxygen asebenzayo ekunciphiseni amandla, kunye nokunikezelwa kwendlela yokusebenza.

Iintlawulo ze Iprroloquinoline quinone(PQQ) izibonelelo

Engqondweni nasemzimbeni, I-PQQ ineentlobo ezahlukeneyo zezibonelelo.

-IpI-QQ ixhasa ukusebenza kwe-mitochondrial efanelekileyo

IMitochondria ngabavelisi bamandla kwiiseli zethu kwaye badlala indima ebalulekileyo kwimpilo yethu iphela. I-PQQ ngokukhusela i-mitochondria ekhoyo kunye nokukhuthaza isizukulwane se-mitochondrial, ke uvelise i-ATP (Amandla). Ukusebenza ngakumbi mitochondria, amandla ngakumbi.

-I-PQQ ixhasa ukhula lwe-nerve

I-PQQ ivuselela ukuveliswa kweNalthi yokukhula kweNalactic (NGF.), Ikhusela kwaye ibuyise iiseli ezonakalisiweyo zeengqondo kunye ne-nerve, ngoko ke kuthintela ukwehla kwengqondo (ukulahleka kwememori, ubunzima bokufunda, njl. Njl.) Ngenxa yobudala, ukubetha okanye ukuphazamiseka kwemithambo-luvo. imisebenzi, kunye nokukhuselwa kwimicimbi yentliziyo kunye ne-neurological.

-PQQ ithintela uxinzelelo lwe-oxidative

I-PQQ ibonelela ngokukhuselwa okunamandla kwe-antioxidant, ikhusela iiseli emzimbeni kumonakaliso we-oxidative kunye ne-demage free radicals. Ixhasa i-metabolism yamandla kunye nokuguga okunempilo, kwaye iqwalasele inoveli cofactor ene-antioxidant kunye ne-B imisebenzi efana ne-B.

Ngaphandle koko, i-PQQ inokuba nokukhusela kwaye inyange ukonakaliswa kwesibindi kunye nomsebenzi oqinileyo we-anticancer.

Ukusetyenziswa / ukusetyenziswa kwe Iprroloquinoline quinone(PQQ)

Kuphononongo luka-2009 olupapashwe kwijenali yezonyango yokuTya, iPyrroloquinoline Quinone ibonakalisiwe ukuba inesakhono sokukhusela. Isetyenziselwa ukunyanga ukwehla kwengqondo (ukulahleka kwenkumbulo, ubunzima bokufunda, njl. Njl.) Ngenxa yobudala, ukubetha okanye ukuphazamiseka kwemithambo-luvo, kunye nokukhuselwa kwimicimbi yentliziyo kunye nesehlo se-ischemic. Iziphumo ezifanayo ziye zaxelwa kuphando lokulandela luka-2011 apho iPyrroloquinoline Quinone nayo yanikwa ngokuthe ngqo njengesongezelelo sokutya, ezinje ngobisi olususela kwisiselo sobisi.

Njani ukuba yanele Iprroloquinoline quinone(PQQ)?

Ebomini, unokufumana i-PQQ kokutya okuthile okune-sourts, ibakho ngokwemvelo iintlobo ezahlukeneyo zokutya kunye neziselo, kubandakanya i-pepper eluhlaza, iparsley, iti okanye i-kiwifruit njl. Nangona kunjalo, ukuba ubale inani lokutya umntu akutya yonke imihla, uninzi kuthi asinakufumana i-PQQ eyoneleyo kwisidlo sethu semihla ngemihla. Ke ngoko, ukuba ufuna izibonelelo ezinkulu ngakumbi, unokufumana i-PQQ engakumbi ngezinye iindlela, ezinje ngePQQ yokutya ezongeziweyo.

Imbekiselo:

  • Drain, Kelsey (nge-12 kaFebruwari 2017). "I-Antioxidant yendalo inokuthi ithintele ukugula kwesibindi". msn.com Ibuyiselwe nge-14 kaFebruwari ngo-2017.
  • U-Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "I-Pyrroloquinoline quinone: ukumbiwa kwemethylotrophs kunye nokukhuthaza ukukhula kwezinto ezincinci". IiBioFactors. 1 (1): 51–3. I-PMID 2855583.
  • UFelton LM, Anthony C (2005). "Biochemistry: indima ye-PQQ njenge-encyme ye-enzyme cofactor?". Indalo. I-433 (7025): i-E10, ingxoxo ye-E11-2. doi: 10.1038 / nature03322. PMID 15689995.
  • U-Westerling J, uFrank J, uDuine JA (1979). "Iqela lesigcini se-methanol dehydrogenase evela kwiHyphomicrobium X: ubungqina be-elenronron resonance ubungqina besakhiwo se-quinone". I-Biochem Biophys Res Cont. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. I-PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline dehydrogenases exhomekeke kwi-acetic acid bacteria.Appl Microbiol Biotechnol. Ngo-2018 i-Nov; i-102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.