I-Pyrroloquinoline quinone (PQQ) (72909-34-3)

Matshi 11, 2019

IPyrroloquinoline quinone (PQQ), ekwabizwa ngokuba yi-methoxatin, yicofactor ebomvu. Ifumaneka emhlabeni nasekutyeni okufana ne-kiwifruit, njengo …… ..

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

I-Pyrroloquinoline quinone (PQQ) (72909-34-3) ividiyo

I-Pyrroloquinoline quinone (PQQ) (72909-34-3) Iinkcukacha

Igama lemveliso Iprroloquinoline quinone (PQQ)
Igama leKhemikhali I-Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Inani leCAS 72909-34-3
InChIKey I-MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
I-Molecular Formula C14H6N2O8
Isisindo somzimba 330.21
IMasaisotopic Mass 330.012415 g / mol
Indawo yokujonga indawo 1018.6 ± 65.0 ° C (Kuxelwe kwangaphambili)
Indawo yokudanyaza I-569.8 ° C (1,057.6 ° F; 842.9 K)
mninzi 1.963 0.06 3 g / cmXNUMX (Kuxelwe kwangaphambili)
umbala I-Orange-Red Solid
Indawo yokugcina 2-8 ° C
Umzimba I-Soluble emanzini
isicelo I-PQQ iye yaxelwa ukuba isebenza njengevithamini enyibilikisa amanzi / i-cofactor kunye ne-antioxidant. Yenzelwe ukusetyenziselwa izongezo zokutya, njengamandla, ukutshintshwa kwesidlo, kunye nemivalo eyomeleleyo njl.

 

Yintoni i Iprroloquinoline quinone(PQQ)?

IPyrroloquinoline quinone (PQQ), ekwabizwa ngokuba yi-methoxatin, yi-redox cofactor. Ifunyanwa emhlabeni kunye nokutya okufana ne-kiwifruit, kunye nobisi lwebele lomntu. I-Pyrroloquinoline quinone yi-pyrroloquinoline enamaqela e-oxo kwizithuba ezi-4 ukuya kwezi-5 kunye namaqela e-carboxy kwiindawo ezi-2-, 7 - 9 kunye ne-XNUMX. Inendima njengevithamini enyibilikiswa ngamanzi kunye ne-cofactor. Kwaye, sisiginali esibonisa iiprotein kinases ezichaphazelekayo ekwahluleni kweeseli ezanyisayo. Amandla aphezulu okuphinda kusetyenziswe kwakhona i-PPQ inokunika indima ye-pharmacological ekukhuseleni ngokuchasene ne-neurodegeneration kunye nomhlaza. (Njenge-arhente ye-redox, iPyrroloquinoline quinone izinzile kakhulu kwaye inokuthatha inxaxheba kwiziphumo ezingamakhulu kunamanye ama-antioxidants, anjenge-ascorbic acid, quercetin, kunye ne-epicatechin.

I-Pyrroloquinoline quinone yi-biofactor yenoveli, kwaye yaqwalaselwa njenge-enzyme cofactor kwiibacteria. Uphando lubonisa ukuba i-Pyrroloquinoline quinone inokuba ibikho ngalo lonke ixesha loqwalaselo lwebhayoloji kunye nokuvela kwendalo. Njengenxalenye yesityalo esinamandla okukhula, ikhona ekukhuleni kwezilwanyana nabantu. I-Pyrroloquinoline quinone inikwe ingxelo yokuba ithathe inxaxheba kuluhlu lwemisebenzi yemvelo eneenzuzo ezibonakalayo zokuphila (umzekelo, ukukhula okuphuculweyo kwe-neonatal kunye nokuzala) kwizilwanyana.

Ngaphezu koko, i-Pyrroloquinoline quinone ine-antioxidant kunye ne-B-vitamin-efana nomsebenzi, onoluhlu olubanzi lwezibonelelo zobuchopho kunye nomzimba. Ikhuthaza impilo kunye nokukhumbula ngokulwa ukungasebenzi kakuhle kwe-mitochondrial kunye nokukhusela i-neurons kumonakalo we-oxidative. Izifundo zeklinikhi ebantwini zibonise ukuba iPyrroloquinoline quinone iphucula inkumbulo yexesha elifutshane kunye nokuqwalaselwa, ukuphucula amandla e-metabolism kunye nokuguga okunempilo, kunye nokunciphisa iimpawu zokuvuvukala, kunye nokuphucula ukuziva ngokubanzi kokuphila.

 

Yenzeka njani iPyrroloquinoline quinone(PQQ) ukusebenza?

Izifundo zempuku zibonisa ukusebenza okumangalisayo kwePyrroloquinoline quinone ekuvuseleleni i-biogenesis ye-mitochondrial. Iigat hepatocytes ezifakwe kwi-PQQ kwi-10-30 μM ye-24-48 h ibonakalise "ukwanda kwe-citrate synthase kunye nomsebenzi we-cytochrome c oxidase, ukubola kweMitotracker, umxholo we-DNA ye-mitochondrial, kunye nokuphefumla kweoksijini yeselula. Ukwenziwa kwale nkqubo kwenzeke ngokusetyenziswa kweprotein yokubopha ye-cAMP ephathekayo (i-CREB) kunye ne-peroxisome proliferator-activated receptor-γ coactivator-1cy (PGC-1α), indlela eyaziwa ngokulawula i-mitochondrial biogenesis. ” Kwizifundo ze-vivo kwiigundane kukwabonisa iziphumo eziluncedo ezivela kwisongezelelo sokutya kunye ne-PQQ (2mg PQQ / kg yokutya). Oku kubandakanya ukunciphisa i-plasma triglycerides, ukwanda kwenkcitho yamandla (ehambelana nomxholo we-hepatic mitochondrial), kunye nokuphucula ukunyamezelana ne-ischemia / reperfusion yentliziyo. Iimodeli zovavanyo zestroke kunye nokwenzakala kwethambo lomqolo zibonisa ukuba iPyrroloquinoline quinone ifumana ukufa kweeseli kwe-neuronal, ngokuyinxalenye ngePyrroloquinoline quinone ekhusela ii-receptors ze-N-methyl-d-aspartic acid (NMDA). Iimodeli zempuku zesifo sikaParkinson zibonisa ukuba iPyrroloquinoline quinone supplementation inciphisa ilahleko ye-neuronal, yonyusa amandla eoksijini asebenzayo, kunye nokunikezela ukukhusela ngeendlela ezongezelelweyo.

 

Iintlawulo ze Iprroloquinoline quinone(PQQ) izibonelelo

Engqondweni nasemzimbeni, I-PQQ ineentlobo ezahlukeneyo zezibonelelo.

-UpI-QQ ixhasa ukusebenza kwe-mitochondrial efanelekileyo

IMitochondria ngabavelisi bamandla kwiiseli zethu kwaye badlala indima ebalulekileyo kwimpilo yethu iphela. I-PQQ ngokukhusela i-mitochondria ekhoyo kunye nokukhuthaza isizukulwane se-mitochondrial, ke uvelise i-ATP (Amandla). Ukusebenza ngakumbi mitochondria, amandla ngakumbi.

-I-PQQ ixhasa ukukhula kwemithambo-luvo

I-PQQ ivuselela ukuveliswa kweNalthi yokukhula kweNalactic (NGF.), Ikhusela kwaye ibuyise iiseli ezonakalisiweyo zeengqondo kunye ne-nerve, ngoko ke kuthintela ukwehla kwengqondo (ukulahleka kwememori, ubunzima bokufunda, njl. Njl.) Ngenxa yobudala, ukubetha okanye ukuphazamiseka kwemithambo-luvo. imisebenzi, kunye nokukhuselwa kwimicimbi yentliziyo kunye ne-neurological.

-I-PQQ ithintela uxinzelelo lwe-oxidative

I-PQQ ibonelela ngokukhuselwa okunamandla kwe-antioxidant, ikhusela iiseli emzimbeni kumonakaliso we-oxidative kunye ne-demage free radicals. Ixhasa i-metabolism yamandla kunye nokuguga okunempilo, kwaye iqwalasele inoveli cofactor ene-antioxidant kunye ne-B imisebenzi efana ne-B.

Ngaphandle koko, i-PQQ inokuba nokukhusela kwaye inyange ukonakaliswa kwesibindi kunye nomsebenzi oqinileyo we-anticancer.

Ukusetyenziswa / ukusetyenziswa kwe Iprroloquinoline quinone(PQQ)

Kuphononongo luka-2009 olupapashwe kwijenali yezonyango yokuTya, iPyrroloquinoline Quinone ibonakalisiwe ukuba inesakhono sokukhusela. Isetyenziselwa ukunyanga ukwehla kwengqondo (ukulahleka kwenkumbulo, ubunzima bokufunda, njl. Njl.) Ngenxa yobudala, ukubetha okanye ukuphazamiseka kwemithambo-luvo, kunye nokukhuselwa kwimicimbi yentliziyo kunye nesehlo se-ischemic. Iziphumo ezifanayo ziye zaxelwa kuphando lokulandela luka-2011 apho iPyrroloquinoline Quinone nayo yanikwa ngokuthe ngqo njengesongezelelo sokutya, ezinje ngobisi olususela kwisiselo sobisi.

 

Njani ukuba yanele Iprroloquinoline quinone(PQQ)?

Ebomini, ungafumana i-PQQ kokunye ukutya sourse, yinto yendalo ngoku kwizidlo kunye neziselo, kubandakanya ipepile eluhlaza, iparsley, iti okanye i-kiwifruit njl.njl. kuthi asinakufumana i-PQQ eyaneleyo kukutya kwethu kwemihla ngemihla. Ke ngoko, ukuba ufuna izibonelelo ezingaphezulu, unokufumana i-PQQ ngakumbi ngezinye iindlela, ezinje nge-PQQ yokutya.

 

Imbekiselo:

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  • UFelton LM, uAnthony C (2005). "I-Biochemistry: indima ye-PQQ njenge-cofactor ye-mammalian mammalian?". Indalo. 433 (7025): E10, ingxoxo E11-2. ikhonkco: 10.1038 / nature03322. IINKCUKACHA:
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  • Matsutani M, Yakushi T. Pyrroloquinoline dehydrogenases exhomekeke kwi-acetic acid bacteria.Appl Microbiol Biotechnol. Ngo-2018 i-Nov; i-102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.