I-NADH 2Na (606-68-8)

Matshi 15, 2020

I-NADH luhlobo lwe-nicotinamide adenine dinucleotide (NAD) enzyme, ifom ye-coenzyme esebenzayo ye-compound kunye nevithamini B3 ……….

 


Isimo: KwiMveliso yoLuntu
I-Synthesized and Customized Available
Amandla: 1277kg / inyanga

I-NADH 2Na (606-68-8) ividiyo

Beta-Nicotinamide adenine dinucleotide disodium salt (NADH 2Na) Iinkcukacha

Igama lemveliso I-Beta-Nikotinamide i-adenine dinucleotide disodium ityuwa (NADH 2Na)
Igama leKhemikhali I-NADH (ityuwa yedisodium); I-Disodium nicotinamide adenine dinucleotide; i-eta-d-ribofuranosyl-3-pyridinecarboxamide, disodiumsalt; beta-NADH Disodium salt; I-Nicotinamide adenine dinucleotide, ehlisiwe;
Inani leCAS 606-68-8
InChIKey I-QRGNQKGQENGQSE-WUEGHLCSSA-L
SMILE C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O.[Na+].[Na+]
I-Molecular Formula C21H27N7Na2O14P2
Isisindo somzimba 709.4
IMasaisotopic Mass 709.088661 g / mol
Indawo yokunyibilika 140-142 ℃
umbala Lubhelu
Sitempile yetanki 2-8 ℃
Umzimba I-H2O: 50 mg / mL, icace gca ecacileyo, etyheli
isicelo Unyango; ukutya kunye nezongezelelo zesondlo;

 

Yintoni i-Beta-Nicotinamide adenine dinucleotide disodium salt (NADH 2Na)?

I-NADH luhlobo lwe-nicotinamide adenine dinucleotide (NAD) ye-enzyme, ifom ye-coenzyme esebenzayo ye-compound kunye ne-vitamin B3. I-NADH (b-Nicotinamide adenine dinucleotide) Ityuwa ye-Disodium, incitshisiwe, ikwabizwa ngokuba yiNicotinamide adenine dinucleotide, yindibaniselwano yempendulo kwi-redox. Imisebenzi yayo njengophinda uvuselele umnikeli kwiinkqubo ze-catabolic kubandakanya i-glycolysis, β-oxidation kunye nomjikelo we-asidi ye-citric (umjikelo weKrebs, umjikelo we-TCA). Ityuwa ye-NADH disodium ikwathatha inxaxheba kwiminyhadala yokubonisa iiseli, umzekelo njenge-substrate ye-poly (ADP-ribose) polymerases (PARPs) ngexesha lokuphendula komonakalo we-DNA. Njengetyuwa ye-disodium ye-NADH, isetyenziselwa ukutya kunye nezongezelelo zesondlo kunyango lwesifo sika-Parkinson, isifo sokudinwa okungapheliyo, isifo se-Alzheimer kunye nezifo zentliziyo.

 

Izibonelelo zeBeta-Nicotinamide adenine dinucleotide disodium salt (NADH 2Na) izibonelelo

Njenge-coenzyme ye-oxidoreductases, i-NADH ye-disodium ityuwa idlala indima ebalulekileyo kwimveliso yamandla omzimba.

-I-NADH ye-disodium ityuwa inokukhokelela kukucaca okungcono kwengqondo, ukuphaphama, uxinzelelo kunye nenkumbulo. Inokonyusa ubukrelekrele bengqondo kwaye inokunyusa imood. Inokonyusa amanqanaba amandla emzimbeni kunye nokuphucula imetabolism, amandla engqondo kunye nokunyamezela.

- Nceda abantu abanexinzelelo lwezonyango, uxinzelelo lwegazi oluphezulu okanye i-cholesterol ephezulu;

-Ukuphucula ukusebenza kweembaleki;

-Cothisa inkqubo yokuguga kunye nokugcina ukuthembeka kweeseli zemithambo-luvo ukuxhasa inkqubo yeemvakalelo;

-May unganyanga isifo sikaParkinson, uphucule ukusebenza kweeurotransmitters kwingqondo yezigulana ezinesifo sikaParkinson, ukunciphisa ukukhubazeka komzimba kunye neemfuno zeziyobisi;

Ukunyanga isifo sokudinwa okungapheliyo (i-CFS), isifo se-Alzheimer kunye nesifo sentliziyo;

-Khusela kwiziphumo ebezingalindelekanga zechiza likaGawulayo elibizwa ngokuba yi-zidovudine (AZT);

-Chasa iimpembelelo zotywala esibindini;

- Jet lag

 

I-Beta-Nikotinamide i-adenine dinucleotide disodium ityuwa (NADH 2Na) imiphumela:

Okwangoku, i-NADH disodium yetyuwa ibonakala ikhuselekile kubantu abaninzi xa isetyenziswe ngokufanelekileyo kunye nexesha elifutshane, ukuya kwiiveki ezili-12. Uninzi lwabantu alunazo naziphi na iziphumo ebezingalindelekanga xa kuthathwa isixa esinconywayo suku ngalunye, eyi-10 mg.

Nangona kunjalo, akukho datha yaneleyo malunga nokusetyenziswa kwe-NADH disodium yetyiwa ngexesha lokukhulelwa kunye nokuncancisa., Ke kufuneka bahlale kwicala elikhuselekileyo kwaye baphephe ukusetyenziswa.

 

Imbekiselo:

  • I-Birkmayer JG, Vrecko C, Volc D, Birkmayer W. Nicotinamide adenine dinucleotide (NADH) -indlela entsha yokunyanga isifo sika-Parkinson. Thelekisa isicelo somlomo nesobuzali. I-Acta Neurol Scand Suppl 1993; 146: 32-5.
  • IBudavari S, ed. Isalathiso seMerck. Umhla we-12. Isikhululo seWhitehouse, NJ: Merck & Co, Inc., 1996.
  • I-Bushehri N, iJarrell ST, uLieberman S, et al. Ukuncitshiswa komlomo kwe-B-nicotinamide adenine dinucleotide (NADH) kuchaphazela uxinzelelo lwegazi, i-lipid peroxidation, kunye neprofayile ye-lipid kwiigundane zegazi (SHR). UGeriatr Nephrol Urol 1998; 8: 95-100.
  • I-Bushehri N, iJarrell ST, uLieberman S, et al. Ukuncitshiswa komlomo kwe-B-nicotinamide adenine dinucleotide (NADH) kuchaphazela uxinzelelo lwegazi, i-lipid peroxidation, kunye neprofayile ye-lipid kwiigundane zegazi (SHR). UGeriatr Nephrol Urol 1998; 8: 95-100.
  • UCastro-Marrero J, uCordero MD, uSegundo MJ, et al. Ngaba i-coenzyme Q10 yokudibanisa ngomlomo kunye ne-NADH eyongezayo iyaphucula ukukhathala kunye neparamitha yepharochemical kwi-Figue Flex syndrome? I-Antioxid Redox Signal 2015; 22 (8): 679-85.
  • UDizdar N, uKagedal B, uLindvall B. Unyango lwesifo sikaParkinson nge-NADH. I-Acta Neurol Scand 1994; 90: 345-7.