I-Nicotinamide riboside chloride (NR-CL) (23111-00-4)

Matshi 11, 2020

INicotinamide riboside (NR) sisandul 'ukufunyanwa kwenicotinamide adenine dinucleotide (NAD +) eyandulela ivithamini. …….

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

Ividiyo yeNicotinamide riboside chloride (NR-CL) (23111-00-4) ividiyo

I-Nicotinamide riboside chloride (NR-CL) (23111-00-4) Suqobo

Igama lemveliso I-Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Igama leKhemikhali NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; INicotinamide BD Riboside Chloride (WX900111); I-NR-CL;
Inani leCAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
I-Molecular Formula C11H15ClN2O5
Isisindo somzimba 290.7002
IMasaisotopic Mass 290.066949 g / mol
Indawo yokunyibilika N / A
umbala mhlophe
Sitempile yetanki -20 ° C Ifreezer
isicelo izongezo zokutya, intsimi yamayeza

 

Yintoni i I-Nicotinamide riboside chloride(NR-CL)?

I-Nicotinamide riboside (NR) yi-nicotinamide adenine dinucleotide entsha (NAD +) eyandulelayo. Uhlobo lwekristali ye-NR chloride ibizwa ngokuba yi-NIAGEN, eyindlela yokwenza i-nicotinamide riboside kunye nomthombo apho i-nicotinamide ngohlobo lwe-nicotinic acid inokufumaneka kwi-bioavava kwaye igqalwa njengekhuselekileyo (GRAS). I-chloride ye-NR ingumxholo wezaziso ezitsha zokutya, ezisetyenziswa ikakhulu kwizongezelelo zokutya.

INicotinamide Riboside Chloride sisixhobo sendalo esifumaneka ebisini. Inxulumene ne-niacin kunye nezinye iindlela zevithamini B3. Olunye uphando lufumanise ukuba iNicotinamide Riboside Chloride inezinto ezizodwa ezinokunyusa imetabolism yomntu ukunceda ukutshisa iikhalori ezingaphezulu nokukhusela ukutyeba. Ukongeza ekunciphiseni ubunzima, ikwanceda ukukhulisa ukusebenza kwezihlunu, ukwandisa inkcitho yamandla, kunye nokunciphisa umngcipheko wesifo seswekile.

Kwakhona, uphando ebantwini lubonise ukuba zozibini ezi ziNicotinamide Riboside Chloride ziphakamisa amanqanaba eNAD +, ezinceda ukuphucula iimeko ezinxulumene nobudala, nangona kusekutsha kakhulu ukwazi ukuba ziya kusebenza njani.

 

iinzuzo I-Nicotinamide riboside chloride(NR-CL)

I-Nicotinamide riboside chloride yindlela yokwenziwa kwe-nicotinamide riboside, izibonelelo zayo / umsebenzi uyafana ne-nicotinamide riboside. Ukuthatha inxaxheba kwimetabolism emzimbeni, kunokusetyenziselwa ukuthintela i-pellagra okanye esinye isifo se-niacin sokuthintela isifo kunye nokuhlisa i-cholesterol kunye ne-triglycerides egazini. Isetyenziselwa ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kubantu abane-cholesterol ephezulu esele benesifo sentliziyo. Ngamanye amaxesha isetyenziselwa ukunyanga isifo semithambo (i-atherosclerosis), ukukhusela ingqondo kunye nesibindi (sentliziyo, isifo seswekile, isifo se-Alzheimer's).

Ngaphandle koko, iNicotinamide riboside chloride inezinye izibonelelo ebantwini:

  • Ukugaya ukutya ngokuchanekileyo kunye nokufunxa kweeprotheni kunye namafutha;
  • Siza ukuguqula i-amino acid tryptophan ebalulekileyo kwi-niacin;
  • Ukunciphisa ukugabha, kunye nokunciphisa iziphumo zokuthatha ii-antidepressant ngenxa yomlomo owomileyo kunye nobunzima bokuchama;
  • Ukukhuthaza i-nucleic acid synthesis kunye nokukhusela ukwaluphala kwezicubu namalungu, ngaloo ndlela ufezekisa injongo yokulibazisa ukuguga;
  • Ukuhamba kancinci kwemisipha yokuhamba kancinci, ukukhubazeka kwethambo kunye nesandla kunye nonyawo;
  • Unyango lwe-hypometabolism ye-kuzaliwa kunye nokunyusa amandla imetabolism;
  • Uthintelo kunye nonyango lokunqongophala kweevithamini B6;
  • Unyango lwe-carpal tunnel syndrome;
  • Inceda ukunciphisa umzimba kunye nokuqinisa ukusebenza kwemisipha.
  • Ukuphucula ukuxhathisa komzimba kwiiseli zomhlaza
  • Thintela ukulahleka kwendlebe
  • Ngaba yindalo yendalo.
  • Ukuthatha imithamo emikhulu kunokuphelisa ukulutha kweziyobisi kwaye ube nesiphumo esihle sokudanjiswa.
  • Ukuphucula ukusebenza kweeseli ze-epidermal, kunye nemisebenzi yezinye iiseli emzimbeni womntu, ukugcina ulusu luvutha.

 

I-Nicotinamide riboside chloride(NR-CL) Ukusetyenziswa

Ngenxa yokuba i-Nicotinamide riboside chloride ineempawu zonyango ezifanelekileyo, ihlala isetyenziswa kwizongezo zokutya, amayeza kunye nendawo yokutya.

 

 

Imbekiselo:

  • Conze D, Brenner C, Kruger CL. Ezokhuseleko kunye neMetabolism yoLawulo lwexesha elide lwe-NIAGEN (Nicotinamide Riboside Chloride) Kwindawo ekungekho si sifo kuyo, uLwazi oluphinda kabini, uLawulo lweKlinikhi oluLawulwa ngabadala abaDala. I-Sci Rep. I-2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. I-PMID: 31278280 PMCID: PMC6611812.
  • IBogan, KL, iBrenner, C. (2008). "I-Nicotinic acid, i-nicotinamide, kunye ne-nicotinamide riboside: uvavanyo lweemolekyuli ze-NAD + zandulela iivithamini kwisondlo sabantu". Annu. UMfu Nutr. 28: 115-130. ikhonkco: 10.1146 / annurev.nutr.28.061807.155443. IINKCUKACHA:
  • Chi Y, Sauve AA (Novemba 2013). "INicotinamide riboside, umkhondo wesondlo ekutyeni, yi-vitamin B3 eneziphumo kumandla emetabolism kunye ne-neuroprotection". I-Curr Opin kwiklinikhi yokuNakekelwa kweMetab. 16 (6): 657-61. ikhonkco: 10.1097 / MCO.0b013e32836510c0. IINKCUKACHA: