I-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Matshi 11, 2020
SKU: 146-48-5
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-NACET (N-Acetylcysteine ​​ethyl ester) yinto ye-eposophine yeseli evumelekileyo yeseli ye-cysteine ​​enento yokwenza ne-pharmacokinetic engaqhelekanga kwaye iphawuleka… ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

Ividiyo-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ividiyo

Ukucaciswa kwe-NACET (59587-09-6)

Igama lemveliso I-NACET (59587-09-6)
Igama leKhemikhali I-R) -ethyl 2-acetamido-3-ze-mercaptopropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-ACETYL-L-CYSTEINE ETHYL ESTER;
I-ethyl (2R)--acetamido-2-sulfanylpropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-Acetylcysteine ​​ethylester;
Inani leCAS 59587-09-6
InChIKey I-MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
I-Molecular Formula C7H13NO3S
Isisindo somzimba 191.25
IMasaisotopic Mass 191.061614 g / mol
Indawo yokunyibilika 44.1-44.5 ° C
Point yo kubilisa 337.6 ± 32.0 ° C (Kuxelwe kwangaphambili)
mninzi 1.138 0.06 3 g / cmXNUMX (Kuxelwe kwangaphambili)
umbala Ngaphandel uBumhlophe
isicelo I-Nootropics kunye neziyobisi smart, zingasetyenziselwa ukukhulisa inkumbulo, ukugxila, ubuchule bokuyila, ubukrelekrele kunye nenkuthazo. Ingasetyenziswa njengezongezelelo zokutya.

Yintoni i I-NACET(N-Acetylcysteine ​​ethyl ester)?

I-NACET (N-Acetylcysteine ​​ethyl ester) yinoveli yophophilic yeseli evumelekileyo yeselsteine ​​enento yokwenza nokungaqhelekanga kwechemacokinetic kunye ne-antioxidant ephawulekayo. I-NACET ine-bioavailability ephezulu yomlomo. Yinto antioxidant eyomeleleyo kunye nesityebi esingesosisityebi se-GSH, esimalunga ne-acid yayo yasimahla N-acetyl -L yahlukile kwi -cycyine (NAC). I-NACET ngumgubo omhlophe kubushushu begumbi kwaye unyibilika ngokukhululekileyo emanzini kunye nezinyibilikisi eziphilayo.

I-NAC sisiphumo esivela kwi-cysteine. Ukusukela kwiminyaka yoo-1970s, isetyenziselwa ukunyanga abaguli abane-acetaminophen overdose kunye nokuphazamiseka kwemithambo, kwaye kuthengiswa njengamayeza kunye nesongezelelo sesondlo. Xa kuthelekiswa ne-NAC, i-NACET ine-lipophilicity ephezulu kunye neeprotechnology eziphuculweyo kakhulu. Inamandla okutshintsha i-NAC ye-pharmacological, njenge-arhente ye-mucolytic, i-antioxidant, umboneleli we-GSH, i-paracetamol antidote, kunye nobuncinci beGala lokuhambisa i-gaseous H 2 S kunye ne-arhente yokhuseleko ye-UV.

Ukongeza, i-nitophilicity eyomeleleyo kunye nokunciphisa amandla e-NACET nayo ibonakalisiwe kwiiseli ezibomvu zegazi lomntu. Kufunyenwe ukuba iqokelele kwiiseli ezibomvu zegazi lomntu, ngokuchasene nomonakalo we-oxidative obangelwa yi-hydroperoxides. Ke ngoko, ukubakho kwe-NACET njenge-anti-nitrite-indved antioxidant kukhulu kunaleyo Nhem methemoglobinemia kunye nezinye ii-oxidants ezomeleleyo. Izifundo kwiigundane zifumanise ukuba i-NACET ifakwe ngokukhawuleza kune-NAC xa i-NACET ilawulwa ngomlomo. Iyakwazi ukungena kwiiseli kwaye ivelise i-NAC kunye ne-cysteine, eyonyusa i-hydrogen sulfide (H (2) S) ekujikelezeni. Ngumgqatswa ofanelekileyo wokusetyenziswa komlomo njengomvelisi weH (2) S,

Izibonelelo zeNACET (I-N-Acetylcysteine ​​ethyl ester)

Njenge-antioxidant enamandla, i-NACET inezibonelelo ezinkulu kwimpilo yabantu.

-Ukuphucula iimeko zempilo ezininzi kunye nokunciphisa iimpawu zokugula kwengqondo;

-Unyango lwe-acetaminophen overdoses, ukukhusela izintso kunye nesibindi;

-Ukuphucula ukusebenza kwemiphunga ngokunciphisa ukuvuvukala kunye nokwaphula i-mucus, ngaloo ndlela kunciphisa izifo ezingapheliyo zokuphefumla.

-Khuthaza impilo yengqondo ngokulawula i-glutamate kunye nokongeza i-glutathione, enokusetyenziselwa ukunyanga izifo ezinjengesifo se-Alzheimer kunye nesifo sikaParkinson;

-Ukuphucula ukuzala kwamadoda nabafazi

-Ukuphucula ukusebenza komzimba kwizifo ezininzi, ukuthintela ukonakaliswa kwe-oxidative kwentliziyo, kunye nokunciphisa umngcipheko wesifo sentliziyo.

-Manje uzinze iswekile yeGazi ngokunciphisa ukuvuvukala kwiiseli zamafutha

Ukusebenza kwe-NAECT (I-N-Acetylcysteine ​​ethyl ester)

Kuba i-NACET ibonakalise iziphumo eziphezulu kwizigulo zengqondo, izifo zokuphefumla ezinganyangekiyo kunye nezigulo zengqondo, ihlala isetyenziswa njengeyeza kunye nesongezelelo sokutya ukukhusela ubuchopho, ukuphucula ukusebenza kwengqondo kunye nomzimba, ukonyusa inkumbulo, ukuqonda kunye nokusebenza kwezemidlalo.

Imbekiselo:

  • I-Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): inoveli ye-lipstein yeseli evunyelweyo ye-cysteine ​​enokuthile okungaqhelekanga kwechemacokinetic kunye nokubanokubakho okumangalisayo kwe-antioxidant. I-Biochem Pharmacol. Ngo-2012 kuDisemba 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) kunye ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -I-Cysteine ​​esekwe kumachiza amachiza aphethe iiprofayili zekhemikhali ezingaqhelekanga zokusetyenziswa komlomo njenge-NO, H2S kunye nabaxhasi be-GSH kunye njengee-antioxidants: Iziphumo kunye nokujonga ngokubanzi. I-2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 ngo-December 13. Uphengululo. I-PMID: 29568662
  • I-N-acetylcysteine ​​ethyl ester njenge-GSH yokuphucula iiseli ezisisiseko se-endothelial seli: Isifundo sokuthelekisa kunye namanye amachiza. I-Oct ka-2018; 126: 202 209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • I-DimitriosTsikasa, uKathrin S.Schwedhelma, uAndrzej Surdackib, uDaniela Giustarinic, uRanieri Rossid, uLea Kukoc-Modune, uGeorge Kediaf, uStefan ertckertf. I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) kunye ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -I-Cysteine ​​esekwe kumachiza amachiza aphethe iiprofayili ezizodwa zekhemikhali yokusetyenziswa komlomo njenge-NO, H2S kunye nabaxhasi be-GSH kunye njengee-antioxidants: Iziphumo kunye nokujonga ngokubanzi. Ijenali yoPhicotho lweMayeza. Umqolo we-8, u-1 kaFebruwari ka-2018, iphepha 1-9.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.