I-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Matshi 11, 2020

I-NACET (N-Acetylcysteine ​​ethyl ester) yinoveli ye-lipophilic cell-permeable cysteine ​​derivative enento engaqhelekanga ye-pharmacokinetic kwaye iyamangalisa… ..

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

Ividiyo-N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ividiyo

Ukucaciswa kwe-NACET (59587-09-6)

Igama lemveliso I-NACET (59587-09-6)
Igama leKhemikhali I-R) -ethyl 2-acetamido-3-ze-mercaptopropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-ACETYL-L-CYSTEINE ETHYL ESTER;
I-ethyl (2R)--acetamido-2-sulfanylpropanoate;
I-L-Cysteine, i-N-acetyl-, i-ethyl ester;
I-N-Acetylcysteine ​​ethylester;
Inani leCAS 59587-09-6
InChIKey I-MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
I-Molecular Formula C7H13NO3S
Isisindo somzimba 191.25
IMasaisotopic Mass 191.061614 g / mol
Indawo yokunyibilika 44.1-44.5 ° C
Point yo kubilisa  337.6 ± 32.0 ° C (Kuxelwe kwangaphambili)
mninzi 1.138 0.06 3 g / cmXNUMX (Kuxelwe kwangaphambili)
umbala Ngaphandel uBumhlophe
isicelo I-Nootropics kunye neziyobisi smart, zingasetyenziselwa ukukhulisa inkumbulo, ukugxila, ubuchule bokuyila, ubukrelekrele kunye nenkuthazo. Ingasetyenziswa njengezongezelelo zokutya.

 

Yintoni i I-NACET(N-Acetylcysteine ​​ethyl ester)?

I-NACET (i-N-Acetylcysteine ​​ethyl ester) yincwadana ye-lipophilic cell-permeable cysteine ​​derivative enento engaqhelekanga ye-pharmacokinetic kunye ne-antioxidant. I-NACET inokufumaneka okuphezulu kokufumaneka komlomo. I-antioxidant etyebileyo eyandulelayo etyebileyo ye-GSH, enxulumene ne-asidi yayo yasimahla i-N-acetyl -L yahlukile kwi -cysteine ​​(NAC). I-NACET yimpuphu emhlophe kubushushu begumbi kwaye inyibilika ngokukhululekileyo emanzini nakwinyibilikisi yendalo.

I-NAC sisiphumo esivela kwi-cysteine. Ukusukela kwiminyaka yoo-1970s, isetyenziselwa ukunyanga abaguli abane-acetaminophen overdose kunye nokuphazamiseka kwemithambo, kwaye kuthengiswa njengamayeza kunye nesongezelelo sesondlo. Xa kuthelekiswa ne-NAC, i-NACET ine-lipophilicity ephezulu kunye neeprotechnology eziphuculweyo kakhulu. Inamandla okutshintsha i-NAC ye-pharmacological, njenge-arhente ye-mucolytic, i-antioxidant, umboneleli we-GSH, i-paracetamol antidote, kunye nobuncinci beGala lokuhambisa i-gaseous H 2 S kunye ne-arhente yokhuseleko ye-UV.

Ukongeza, i-nucleophilicity eyomeleleyo kunye nokunciphisa ukubakho kwe-NACET kuye kwangqinwa kwiiseli ezibomvu zegazi lomntu. Kufunyenwe ukuqokelela kwiiseli ezibomvu zegazi lomntu, ukuxhathisa ngokufanelekileyo umonakalo we-oxidative obangelwa yi-hydroperoxides. Ke ngoko, ukubanakho kwe-NACET njenge-anti-nitrite-indased antioxidant inkulu kakhulu kunaleyo ye-NAC methemoglobinemia kunye nezinye ii-oxidants ezinamandla. Izifundo kwiigundane zifumanise ukuba i-NACET ifunxwe ngokukhawuleza okukhulu kune-NAC xa ilawulwa ngomlomo. Iyakwazi ukungena kwiiseli kwaye ivelise i-NAC kunye necysteine, eyonyusa i-hydrogen sulfide (H (2) S) ekujikelezeni. Ngumgqatswa ofanelekileyo wokusetyenziswa ngomlomo njengomvelisi we-H (2) S,

 

Izibonelelo zeNACET (I-N-Acetylcysteine ​​ethyl ester)

Njenge-antioxidant enamandla, i-NACET inezibonelelo ezinkulu kwimpilo yabantu.

-Ukuphucula iimeko ezininzi zempilo kunye nokunciphisa iimpawu zokugula ngengqondo;

- Unyango lwe-acetaminophen overdoses, ukukhuselwa kwezintso kunye nesibindi;

-Uphucula ukusebenza kwemiphunga ngokunciphisa ukudumba kunye nokwaphula i-mucus, ngalo ndlela kuncitshiswe izifo ezingapheliyo zokuphefumla.

-Khuthaza impilo yengqondo ngokulawula i-glutamate kunye nokuxhasa i-glutathione, inokusetyenziselwa ukunyanga izifo ezinje ngesifo se-Alzheimer kunye nesifo sika-Parkinson;

-Ukuphucula ukuzala kwamadoda nabasetyhini

-Angaphucula ukusebenza kwamajoni omzimba kwizifo ezininzi, kuthintele umonakalo kwi-oxidative entliziyweni, kunye nokunciphisa umngcipheko wesifo sentliziyo.

-Kwangathi ngoMeyi kuzinziswe iSwekile yeGazi ngokuThoba ukuDumba kwiiSeli zeFat

 

Ukusebenza kwe-NAECT (I-N-Acetylcysteine ​​ethyl ester)

Ngenxa yokuba i-NACET ibonakalise iimpembelelo kwizigulo zengqondo, isifo esinganyangekiyo sokuphefumla kunye nokugula ngengqondo, ihlala isetyenziswa njengeyeza kunye nokongezwa kokutya ukukhusela ingqondo, ukuphucula ukusebenza kwengqondo kunye nomzimba, ukongeza inkumbulo, ukuqonda kunye nokusebenza kwezemidlalo.

 

Imbekiselo:

  • I-Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): inoveli ye-lipstein yeseli evunyelweyo ye-cysteine ​​enokuthile okungaqhelekanga kwechemacokinetic kunye nokubanokubakho okumangalisayo kwe-antioxidant. I-Biochem Pharmacol. Ngo-2012 kuDisemba 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) kunye ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -I-Cysteine ​​esekwe kumachiza amachiza aphethe iiprofayili zekhemikhali ezingaqhelekanga zokusetyenziswa komlomo njenge-NO, H2S kunye nabaxhasi be-GSH kunye njengee-antioxidants: Iziphumo kunye nokujonga ngokubanzi. I-2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 ngo-December 13. Uphengululo. I-PMID: 29568662
  • I-N-acetylcysteine ​​ethyl ester njenge-GSH yokuphucula iiseli ezisisiseko se-endothelial seli: Isifundo sokuthelekisa kunye namanye amachiza. I-Oct ka-2018; 126: 202 209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • I-DimitriosTsikasa, uKathrin S.Schwedhelma, uAndrzej Surdackib, uDaniela Giustarinic, uRanieri Rossid, uLea Kukoc-Modune, uGeorge Kediaf, uStefan ertckertf. I-S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) kunye ne-N-acetyl-L-cysteine ​​ethyl ester (NACET) -I-Cysteine ​​esekwe kumachiza amachiza aphethe iiprofayili ezizodwa zekhemikhali yokusetyenziswa komlomo njenge-NO, H2S kunye nabaxhasi be-GSH kunye njengee-antioxidants: Iziphumo kunye nokujonga ngokubanzi. Ijenali yoPhicotho lweMayeza. Umqolo we-8, u-1 kaFebruwari ka-2018, iphepha 1-9.