Ityuwa ye-NADP disodium (24292-60-2)

Matshi 15, 2020
SKU: 164656-23-9
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Nicotinamide adenine dinucleotide phosphate (NADP +) yi-cofactor esetyenzisiweyo ekuphenduleni kwe-anabolic. β-I-Nicotinamide adenine ………


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

I-NADP disodium yetyuwa (24292-60-2) ividiyo


I-β-Nicotinamide adenine dinucleotide phosphate disodium ityuwa (ityuwa ye-NADP disodium)uqobo

Igama lemveliso I-β-Nicotinamide adenine dinucleotide phosphate disodium salt (ityuwa ye-NADP disodium)
Igama leKhemikhali I-NADP Disodium; Nadide phosphate disodium; I-NADP; β-NADP; I-Triphosphopyridine nucleotide disodium ityiwa;
Inani leCAS 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
I-Molecular Formula C21H26N7Na2O17P3
Isisindo somzimba 787.37
IMasaisotopic Mass 787.039342 g / mol
Indawo yokunyibilika 175-178 ° C
umbala Lubhelu
Sitempile yetanki -20 ° C
amanzi Umzimba > 50 g / L
isicelo Coenzyme kwi-aerobic kunye ne-anaerobic oxidations

Yintoni i-β-Nicotinamide adenine dinucleotide phosphate disodium salt (ityuwa ye-NADP disodium)?

I-Nicotinamide adenine dinucleotide phosphate (NADP +) yi-cofactor esetyenzisiweyo ekuphenduleni kwe-anabolic. I-β-Nicotinamide adenine dinucleotide phosphate disodium ityuwa ye-disodium ye-NADP +, iyimfuneko ye-coenzyme yesiselo esinxilisayo seswekile yeglue kunye ne-oxidative dehydrogenation zezinye izinto. Kwaye kwenzeka ngokubanzi kwizicubu eziphilayo, ngakumbi kwisibindi.

I-Nicotinamide adenine dinucleotide phosphate (NADP) kunye ne-NADPH zenza isibini se-redox. Umlinganiselo we-NADPH / NADP ulawula i-intracellular redox enokubakho, ngakumbi impendulo ye-anaerobic, apho ke ichaphazela impendulo ye-metabolic emzimbeni. Imizekelo ye-lipid kunye ne-nucleic acid synthesis. I-NADP ikwangumbala we-coenzyme kwiinkqubo ezahlukeneyo ze-cytochrome P450 kunye ne-oxidase / reductase reaction system efana ne-thioredoxin reductase / inkqubo ye thioredoxin.

I-NADPH ibonelela ukunciphisa ukulingana ekuphenduleni kwe-biosynthetiki kwaye ibonelele ngefuthe le-redox ukuthintela ubungozi beentlobo zeeoksijini ezisebenzayo (ROS), ngaloo ndlela iphinda ivelise glutathione (GSH). Ikwasetyenziswa kwiindlela ze-anabolic ezinje nge-cholesterol synthesis kunye nokwandiswa kwamafutha acid.

Ukongeza, inkqubo ye-NADPH ikwanoxanduva lokuvelisa i-radicals yasimahla kumaseli omzimba ngokusebenzisa i-NADPH oxidase. Ezi radicals zasimahla zisetyenziselwa ukutshabalalisa ii-pathogens kwinkqubo ebizwa ngokuba kukuphefumla. Kukucutha ukulingana komthombo we-cytochrome P450 hydroxylated aromatics, steroids, alcohols, and drug.

isicelo ye-β-Nicotinamide adenine dinucleotide phosphate disodium ityuwa

I-Nicotinamide adenine dinucleotide phosphate (NADP) kunye ne-NADPH zenza isibini se-redox. I-NADP / NADPH yi-coenzyme exhasa ukusabela kwe-redox ngokuhanjiswa kwee-elektroni kuloluhlu olukhulu lwezicelo, ngakumbi iimpendulo ze-anaerobic ezifana ne-lipid kunye ne-nucleic acid synthesis. I-NADP / NADPH sisibini esine-coenzyme kwiinkqubo ezahlukeneyo ze-cytochrome P450 kunye neenkqubo zokuphendula ze-oxidase / reductase, ezifana ne-thioredoxin reductase / inkqubo ye thioredoxin.

Ezinye ii-enzymes ezisebenzisa i-NADP njenge-coenzyme zezi: Utywala dehydrogenase: ukuxhomekeka kweNADP; I-aromatic ADH: Ukuxhomekeka kweNADP; Ukucuthwa kwakhona kweFfereoxin-NADP; I-L-Fucose dehydrogenase; Indawo yedatha; Ukudluliselwa kwe-uridyl ye-Galactose-1-phosphate; Iglucose dehydrogenase; I-L-Glutamic dehydrogenase; I-Glycerol dehydrogenase: I-NADP ethile; Isocitric dehydrogenase; Ii-enzymes zeMalic; I-5,10-Methylenetetrahydrofolate dehydrogenase; I-6-Phosphogluconate dehydrogenase kunye ne-Succinic semialdehyde dehydrogenase.

Imbekiselo:

  • I-Hashida SN, Kawai-Yamada M. I-Inter-Organelle NAD Metabolism Ngaphantsi koKukhanyisa Ukuphendula okuMandla kweNADP kwiZityalo. Inzululwazi yezityalo ezingaphambili. I-2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • UTak U, Vlach J, Garza-Garcia A, uWilliam D, uDanilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Isifo sephepha esine-tocrin ye-NAD + kunye ne-NADP + glycohydrolase eneempawu ezizodwa ze-enzymatic.J Biol Chem. I-2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • U-Liang J, Huang H, u-Wang S. ukuhanjiswa, ukuvela kwezinto, ukuSebenza kweCatalytic, kunye neMisebenzi yePhysical yeFlavin-Isekwe kwi-Electron-Bifurcating ye-NADH-Oxhomekekileyo ukunciphisa i-Fferoxin: NADP + Oxidoreductase. Ngaphambili Microbiol. I-2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • I-Kawai S, iMurata K. "Ulwakhiwo nomsebenzi we-NAD kinase kunye ne-NADP phosphatase: ii-enzymes eziphambili ezilawula ukulingana kwe-NAD (H) ne-NADP (H)". I-Bioscience, i-Biotechnology, kunye ne-Biochemistry. I-72 (4): 919-30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • IHanukoglu I. "Ulondolozo lweeNdalo ze-Enzyme-Coenzyme kwi-FAD ne-NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Ijenali yokuzivelela kweMolekyuli. 85 (5-6): 205–218. Ikhabhodi: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

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