I-Ganglioside GT1b (59247-13-1)

Matshi 15, 2020

Igama elithi Ganglioside laqala ukusetyenziswa ngusosayensi waseJamani u-Ernst Klenk ngo-1942 kwiipids ezisandula ukwenziwa ezivela kwiiseli zemigulukudu yobuchopho… ..

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

IGanglioside GT1b (59247-13-1) ividiyo

IGanglioside GT1b Suqobo

Igama lemveliso IGanglioside GT1b
Igama leKhemikhali GANGLIOSIDE GT1B TRISODIUM ITYUYI; I-GT1B 3NA; I-GT1B-GANGLIOSIDE; I-GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) ukusuka kwingqondo yeenkomo; i-trisialoganglioside-gt1b evela kwingqondo ye-bovine; KWI-GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + ityuwa)
Inani leCAS 59247-13-1
InChIKey I-SDFCIPGOAFIMPG-VLTFPFDUSA-N
I-Molecular Formula C95H162N5Na3O47
Isisindo somzimba 2158.4 g / mol
IMasaisotopic Mass 2157.119189 g / mol
Indawo yokunyibilika N / A
Sitempile yetanki -20 ° C
Umzimba I-DMSO: inyibilika
isicelo Unyango; chromatography;

 

Yintoni i Ganglioside GT1b?

Igama elithi Ganglioside laqala ukusetyenziswa sisazinzulu saseJamani u-Ernst Klenk ngo-1942 kwii-lipids ezisandula ukubekwa zodwa ezivela kwiiseli zengqondo. Yimolekyuli eyakhiwe yiglycosphingolipids (iiceramides kunye neeoligosaccharides) kunye nenye okanye iiasidi zeasialic ezinxulunyaniswe netyathanga leswekile. Liyinxalenye yelungu lecytoplasmic elilawula imicimbi yokuhanjiswa kwesiginali yeselfowuni. Zingaphezulu kwe-60 iintlobo ze-gangliosides ezaziwayo, kwaye umahluko ophambili phakathi kwazo sisikhundla kunye nenani lentsalela yeNANA.

I-Ganglioside GT1b yenye ye-gangliosides kwaye yi-trisialic ganglioside enezinto ezimbini ze-sialic acid ezinxulunyaniswe neyunithi yangaphakathi yegalactose. Inefuthe kuthintelo ekuphenduleni komzimba we-humoral. Kwi-0.1-10 μM, inokuthintela ukuveliswa okuzenzekelayo kwe-IgG, i-IgM kunye ne-IgA ngoonobumba begazi beeseli zenyukliya. I-Ganglioside GT1b ikwacetyisiwe njengendawo yokubamba iseli eyamkela iMerkel cell polyoma virus kwaye njengesixhobo esinokubangela usulelo olubangela iMerkel cell carcinoma.

I-Ganglioside GT1b ikwachaphazelwe kaninzi kwimisipha yomhlaza kwaye ithathwa njengeqela lemigulukudu elinxulumene nemetrophu yobuchopho. Izifundo zifumene ukuba i-GM1, i-GD1a, kunye ne-GT1b ineziphumo ezingavakaliyo zokukhula kwesifo se-epermermal signal signation and adhesion andhifting of keratinocyte, kwaye ubukho bazo bunokuba luphawu lwe-biomarker yokuvavanya ubuchule be-metastatic yengqondo.

IGanglioside GT1b ikwachaphazela amajoni omzimba. I-Ganglioside GT1b inefuthe kuthintelo kumzimba womntu ekuphenduleni komzimba kwaye inqanda ii-immunoglobulins eziveliswe ziiseli zegazi ze-mononuclear. Kukho ubungqina bokuba i-GD1b, i-GT1b, kunye ne-GQ1b inokuphucula imveliso ye-cytokines ye-Th1 ngokuthintela ukusebenza kwe-adenylate cyclase, ngelixa kuthintela ukuveliswa kwe-Th2.

Njenge-receptor eqonda ubuthi obahlukeneyo besakhiwo sayo i-oligosaccharide, i-ganglioside GT1b iyindawo eyamkela ngayo into ethi Clostridium botulinum bacterium botulinum neurotoxin ingena kwiiseli zemithambo-luvo. Uphononongo lubonise ukuba i-tetanus toxin ingena kwiiseli ze-nerve ngokufakelwa i-GT1b kunye nezinye ii-gangliosides, zithintela ukukhutshwa kwe-neurotransmitters kwinkqubo ye-nerve ephakathi, kwaye ibangela ukukhubazeka komzimba. Uhlobo lwe-botulinum C ye-neurotoxin engena kwi-nerve iphande ukuba kwenzeka ntoni kwi-apoptotic yeeseli eziveliswa yi-ganglioside GT1b yokubopha kwi-neuroblastoma.

Ukongeza, i-ganglioside GT1b ilawula kakubi ukuhamba kweeseli, ukungqinisisa, kunye nokubambelela kwi-fibronectin (FN) ngokusebenzisana ngokuthe ngqo kweeseli kunye ne-α5 subunit ye-α5β1 inclin, isiphumo esinokusetyenziselwa ukuphuhlisa unyango lomhlaza. Ukudityaniswa kwe-GT1b kunye ne-MAG kumphezulu we-neurons kungalawula ukusebenzisana kwe-GT1b kwilungu leplasma yee-neurons, kukhokelela ekuthinteleni ukukhula kwe-neurite.

 

Izibonelelo ze-Ganglioside GT1b

I-Ganglioside GT1b yi-acid glycosphingolipid eyakha i-lipid rafts kwiiseli ze-neuronal zenkqubo ye-nervous system kwaye ibandakanyeka ekunyukeni kweseli, umahluko, ukunamathela, ukuhanjiswa komqondiso, ukuhlangana kweseli-iseli, ukudibana kwemithambo-luvo kunye nemastastasis.

Ukuphendula ngokuzenzekelayo kwi-gangliosides kunokukhokelela kwisifo seGuillain-Barre. I-Ganglioside GT1b induces dopaminergic neuron degeneration, enokuba negalelo ekuqaleni okanye kuphuhliso lwesifo sika-Parkinson.

I-Ganglioside GT1b yi-scavenger ye-radicals yasimahla ye-OH, ekhusela ubuchopho kumonakalo we-mtDNA, ukubanjwa kunye ne-lipid peroxidation ebangelwa ngabavelisi beoksijini esebenzayo.

I-Ehrlich tumors ibonisa i-ganglioside GT1b, kwaye i-anti-GT1b inamandla amakhulu onyango olunokubakho kulo mhlaza. Le ganglioside ikwanxulunyaniswa nesifo iMiller Fisher.

 

Imiphumo emibi ye Ganglioside GT1b

I-Gangliosides inokubopha kwi-lectins, isebenze njengama-immune and rechesors receptors, ithathe inxaxheba ekusayinweni kweeseli, i-carcinogenesis kunye nokwahlula iseli, ichaphazela ukwakhiwa kwe-placenta kunye nokukhula kwentsholongwane, ithathe inxaxheba kuzinzo lwe-myelin kunye nokuphinda kuveliswe izintso, kwaye isebenze njengezintsholongwane kunye nokungena kwetyhefu kwiiseli. .

Ukuqokelelwa kwe-ganglioside GT1b kudityaniswe nezifo ezininzi kubandakanya isifo seThai-Sachs kunye nesifo seSandhof.

I-Ganglioside GT1b inqanda i-antigen okanye i-mitogen-induction ye-T yanda impendulo yeseli kwaye ichongiwe njenge-botulinum toxin receptor, ityhefu enqabileyo eneziphumo ezibi zomzimba.

I-Ganglioside GT1b ikhona phantse kuphela kwiiseli zemithambo-luvo kwaye ibonakalisiwe kwi-adventitia. I-GT1b ikhuthaza ukwahlulahlula kwe-neuronal kunye nokwenziwa kwe-dendritic, evelisa isimilo esibi kwaye inyusa i-hyperalgesia kunye ne-allodynia.

IGanglioside GT1b inokuchaphazela amajoni omzimba. Inefuthe kuthintelo ekuphenduleni komzimba wokuzikhusela komzimba kwaye inqanda i-immunoglobulin eveliswe ligazi lomntu leeseli zenyukliya.

Ukongeza, iGanglioside GT1b inxulumene nezi zifo zilandelayo: umkhuhlane, isifo se-guillain-garré, ikholera, isifo sokuqina kwemiphunga, i-botulism, iqhenqa nokutyeba kakhulu.

 

Imbekiselo:

  • U-Erickson, KD, Garcea, RL, kunye no-Tsai, B. Ganglioside GT1b sisixhobo esamkelekileyo sokubamba iiseli zeMerkel cell polyomavirus. Ijenali ye-Virology 83 (19), 10275-10279 (2009).
  • I-Kanda, N., kunye neTamaki, K. Ganglioside GT1b icinezela ukuveliswa kwe-immunoglobulin yiiseli zenyukliya zegazi zomntu. I-Immunology 96 (4), 628-633 (1999).
  • I-Schengrund, C.-L., DasGupta, i-BR, kunye neRandler, NJ Ukubopha kwe-botulinum kunye ne-tetanus neurotoxins ukuya kwi-ganglioside GT1b kunye nokuphuma kuyo. J. Neurochem. 57 (3), 1024-1032 (1991).
  • IiGangliosides, ulwakhiwo, ukwenzeka, ibhayoloji kunye nohlalutyo ”. ILayibrari yeLipid. Umbutho waseMelika weeKhemikhali zeoyile. Kugciniwe kwindawo yokuqala ngo-2009-12-17.
  • UNicole Gaude, Ijenali yeChemicals yeBiology, Vol. 279: 33 iphe. 34624-34630, 2004.
  • U-Elizabeth R Sturgill, u-Kazuhiro Aoki, u-Pablo HH Lopez, njl.njl.I-Biosynthesis ye-gangliosides enkulu ye-GD1a kunye ne-GT1b. IGlycobiology, Umqulu 22, Ikhutshwa nge-10, Okthobha 2012, iphepha 1289–