I-Ganglioside GT1b (59247-13-1)

Matshi 15, 2020
SKU: 167933-07-5
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

Igama iGanglioside laqala ukusetyenziswa sisazinzulu saseJamani u-Ernst Klenk ngo-1942 ukuya kwi-lipids entsha kwizisele zeengqondo zeqela leengqondo ... ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

IGanglioside GT1b (59247-13-1) ividiyo

IGanglioside GT1b Suqobo

Igama lemveliso Ganglioside GT1b
Igama leKhemikhali I-GANGLIOSIDE GT1B TRISODIUM SALT; I-GT1B 3NA; I-GT1B-GANGLIOSIDE; I-GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) ukusuka kwingqondo ye-bovine; trisialoganglioside-gt1b evela kwingqondo ye-bovine; I-GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; I-Trisialoganglioside GT1b (NH4 + ityuwa)
Inani leCAS 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
I-Molecular Formula C95H162N5Na3O47
Isisindo somzimba 2158.4 g / mol
IMasaisotopic Mass 2157.119189 g / mol
Indawo yokunyibilika N / A
Sitempile yetanki -20 ° C
Umzimba I-DMSO: inyibilika
isicelo Unyango; chromatography;

Yintoni i Ganglioside GT1b?

Igama iGanglioside laqala ukusetyenziswa sisazinzulu saseJamani u-Ernst Klenk ngo-1942 ukuya kwi-lipids entsha kwiiseli zeqela leengqondo. Yimolekyuli equlathe i-glycosphingolipids (i-ceramides kunye ne-oligosaccharides) kunye neesicic acid enye okanye ezingaphezulu ezidityaniswe kwityathanga leshukela. Licandelo le-membtane ye-cytoplasmic elawula imicimbi yokuhambisa umqondiso weselula. Zingaphezulu kwe-60 iintlobo zeqela lemigulukudu eyaziwayo, kwaye umahluko ophambili phakathi kwabo sisikhundla nenani leentsalela zeNANA.

IGanglioside GT1b yenye yeendlela ezininzi zemigulukudu kwaye yindawo ekuthiwa yi-geniosic ganglioside eneentsalela ezimbini ze-sialic acid ezixhunywe kwiyunithi yangaphakathi yegalactose. Inefuthe lokuthintela amandla okuphendula omzimba okunyibilikayo. Kwi-0.1-10 μM, inokuthintela ukuveliswa okuzenzekelayo kwe-IgG, i-IgM kunye ne-IgA ngamalungu eseli egazi. IGanglioside GT1b iphinde yacetyiswa njengendawo eyamkela i-cell receptor ye-Merkel cell polyoma virus kwaye njengendlela enokuphelisa usulelo olubangela iMerkel cell carcinoma.

I-Ganglioside GT1b ikwachaphazelwe kaninzi kwimisipha yomhlaza kwaye ithathwa njengeqela lemigulukudu elinxulumene nemetrophu yobuchopho. Izifundo zifumene ukuba i-GM1, i-GD1a, kunye ne-GT1b ineziphumo ezingavakaliyo zokukhula kwesifo se-epermermal signal signation and adhesion andhifting of keratinocyte, kwaye ubukho bazo bunokuba luphawu lwe-biomarker yokuvavanya ubuchule be-metastatic yengqondo.

IGanglioside GT1b ichaphazela amajoni omzimba. IGanglioside GT1b inefuthe elithintelayo ekuphenduleni komzimba ngokudodobalisa komzimba kunye nokuthintela i-immunoglobulins eveliswa ziiseli zegazi eziyimibhobho yegazi. Kukho ubungqina bokuba i-GD1b, GT1b, kunye ne-GQ1b inokunyusa ukuveliswa kwee-cytokines ze-Th1 ngokuthintela umsebenzi we-adenylate cyclase, ngelixa kuthintela ukuveliswa kwe-Th2.

Njenge-receptor eqonda ubuthi obahlukeneyo besakhiwo sayo i-oligosaccharide, i-ganglioside GT1b iyindawo eyamkela ngayo into ethi Clostridium botulinum bacterium botulinum neurotoxin ingena kwiiseli zemithambo-luvo. Uphononongo lubonise ukuba i-tetanus toxin ingena kwiiseli ze-nerve ngokufakelwa i-GT1b kunye nezinye ii-gangliosides, zithintela ukukhutshwa kwe-neurotransmitters kwinkqubo ye-nerve ephakathi, kwaye ibangela ukukhubazeka komzimba. Uhlobo lwe-botulinum C ye-neurotoxin engena kwi-nerve iphande ukuba kwenzeka ntoni kwi-apoptotic yeeseli eziveliswa yi-ganglioside GT1b yokubopha kwi-neuroblastoma.

Ukongeza, i-ganglioside GT1b ilawula kakubi ukuhamba kweeseli, ukungqinisisa, kunye nokubambelela kwi-fibronectin (FN) ngokusebenzisana ngokuthe ngqo kweeseli kunye ne-α5 subunit ye-α5β1 inclin, isiphumo esinokusetyenziselwa ukuphuhlisa unyango lomhlaza. Ukudityaniswa kwe-GT1b kunye ne-MAG kumphezulu we-neurons kungalawula ukusebenzisana kwe-GT1b kwilungu leplasma yee-neurons, kukhokelela ekuthinteleni ukukhula kwe-neurite.

Izibonelelo ze-Ganglioside GT1b

I-Ganglioside GT1b yi-acid glycosphingolipid eyakha i-lipid rafts kwiiseli ze-neuronal zenkqubo ye-nervous system kwaye ibandakanyeka ekunyukeni kweseli, umahluko, ukunamathela, ukuhanjiswa komqondiso, ukuhlangana kweseli-iseli, ukudibana kwemithambo-luvo kunye nemastastasis.

Impendulo ze-Autoimmune kwi-gangliosides zingakhokelela kwisifo se-Guillain-Barre. I-Ganglioside GT1b inciphisa i-dopaminergic neuron degeneration, enokuba negalelo ekuqaleni okanye ekuphuhlisweni kwesifo sika-Parkinson.

I-Ganglioside GT1b yi-scavenger ye-radicals yasimahla ye-OH, ekhusela ubuchopho kumonakalo we-mtDNA, ukubanjwa kunye ne-lipid peroxidation ebangelwa ngabavelisi beoksijini esebenzayo.

I-Ehrlich tumors ibonisa i-ganglioside GT1b, kwaye i-anti-GT1b inamandla amakhulu onyango olunokubakho kulo mhlaza. Le ganglioside ikwanxulunyaniswa nesifo iMiller Fisher.

Imiphumo emibi ye Ganglioside GT1b

I-Gangliosides inokubopha kwi-lectins, isebenze njengama-immune and rechesors receptors, ithathe inxaxheba ekusayinweni kweeseli, i-carcinogenesis kunye nokwahlula iseli, ichaphazela ukwakhiwa kwe-placenta kunye nokukhula kwentsholongwane, ithathe inxaxheba kuzinzo lwe-myelin kunye nokuphinda kuveliswe izintso, kwaye isebenze njengezintsholongwane kunye nokungena kwetyhefu kwiiseli. .

Ukuqokelelwa kwe-ganglioside GT1b kudityaniswe nezifo ezininzi kubandakanya isifo seThai-Sachs kunye nesifo seSandhof.

I-Ganglioside GT1b inqanda i-antigen okanye i-mitogen-induced T cell proliferation reaction kwaye ichongiwe njenge-botulinum receptor receptor, itoxin enqabileyo eneziphumo ezibi zomzimba.

I-Ganglioside GT1b ikhona phantse ngokukodwa kwizisele ze-nerve kwaye ichazwe kwi-adventitia. I-GT1b ikhuthaza umahluko we-neuronal kunye nokwakheka kwe-dendritic, okuvelisa ukungaziphathi kakuhle kunye nokuphucula i-hyperalgesia kunye ne-allodynia.

IGanglioside GT1b inokuchaphazela amajoni omzimba. Inesiphumo sokuthintela amandla okuphendula omzimba omntu emzimbeni kwaye ithintela i-immunoglobulin eveliswa ziiseli zegazi eziyimithambo yegazi.

Ukongeza, iGanglioside GT1b ihambelana nezi zifo zilandelayo: umkhuhlane, isifo se-guillain-garré syndrome, ikholera, isifo sokuqina kwesisu, isifo sokuqaqamba kwamathumbu, iqhenqa kunye nokukhuluphala.

Imbekiselo:

  • U-Erickson, KD, Garcea, RL, kunye no-Tsai, B. Ganglioside GT1b sisixhobo esamkelekileyo sokubamba iiseli zeMerkel cell polyomavirus. Ijenali ye-Virology 83 (19), 10275-10279 (2009).
  • I-Kanda, N., kunye neTamaki, K. Ganglioside GT1b icinezela ukuveliswa kwe-immunoglobulin yiiseli zenyukliya zegazi zomntu. I-Immunology 96 (4), 628-633 (1999).
  • I-Schengrund, C.-L., DasGupta, i-BR, kunye neRandler, NJ Ukubopha kwe-botulinum kunye ne-tetanus neurotoxins ukuya kwi-ganglioside GT1b kunye nokuphuma kuyo. J. Neurochem. 57 (3), 1024-1032 (1991).
  • I-Gangliosides, ulwakhiwo, ukwenzeka, ibhayiloji nohlalutyo ”. Ithala leencwadi laseLipid. Umbutho waseAmerican iichemicals Ishicilelwe kwasekuqaleni ngo-2009 ukuya ku-12 ukuya ku-17.
  • UNicole Gaude, Ijenali yeChemicals yeBiology, Vol. 279: 33 iphe. 34624-34630, 2004.
  • U-Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, njl. Biosynthesis yeqela eliphambili lobuchopho GD1a kunye GT1b. I-Glycobiology, Umqulu 22, Ishumi, Oktobha 10, iphepha 2012–

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