I-Raw Tianeptine i-sodium ityuwa ye powder (30123-17-2)

Oktobha 30, 2018

I-Tianeptine ityiwa yetyuwa yomgubo yitriki ye-tricyclic, sisincedisi esikhethiweyo se-5-HT (serotonin; sc-201146) yokuthatha in vitro….


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1290kg / inyanga

I-Raw Tianeptine i-sodium ityuwa ye powder (30123-17-2) ividiyo

 

I-Raw Tianeptine i-sodium ityuwa ye powder (30123-17-2) Iinkcukacha

Igama lemveliso I-Raw Tianeptine yetyuyamu yeryuwa
Igama leKhemikhali Tianeptine sodium; I-Tianeptine ityuwa yeryudi; 30123-17-2; Stablon; Coaxil;
uhlobo Numama N / A
Iqela leziyobisi N / A
Inani leCAS 30123-17-2
InChIKey HNTRDGDHBBFLPG-UHFFFAOYSA-M
I molecular Fi-ormula C21H24ClN2NaO4S
I molecular WSibhozo 458.93
IMasaisotopic Mass 458.104 g / mol
Ukuxuba Point  1800C
Bilisaba Point 609.2 ° C kwi-760 mmHg
I-Biological Half-Life N / A
umbala Umhlophe ukuya kutsho-omhlophe
Sukufaneleka  I-DMSO: ≥20mg / mL
Sisibetho Tukushisa  Desiccate kwi RT
Aukuguquka I-tianeptine ityhudi yeryuwa yerhasi iyityuwa ye-Tianeptine.

Tianeptine ixinzeleleka.

 

I-Raw Tianeptine i-sodium ityuwa ye powder (30123-17-2) Inkcazo

I-Tianeptine ityuwa yesodium yityuwa yeTianeptine. I-Tianeptine, i-tricyclic compound, i-facilitator ekhethiweyo ye-5-HT (i-serotonin; i-sc-201146) ifumaneka kwi-vitro nakwi-vivo. Ukongezelela, i-Tianeptine ibikwa ukuba isebenze njenge-inhibitor yokukhetha i-dopamine kwaye ifana ne-amineptine. I-Tianeptine ayinayo impembelelo ephawukileyo kwi-monoamine. Kwisifundo esisebenzisa i-synaptosomes ecocekileyo kwi-brain brain, i-Tianeptine yaxelwa ukuba ikhulise i-serotonin ekukhethiweyo kwimiba yengqondo. I-synaptosomes ehlanjululweyo yafunyaniswa kwiigundane kwaye iqhutshwe nge-tritium-ebizwa nge-5-HT ne-Tianeptine kwi-vitro. I-synaptosomes yahlaziywa ngokufunyanwa nokukhutshwa kwe-5-HT nge-counter scintillation counter.

I-Raw Tianeptine i-sodium ityuwa ye-powder yi-antiypicalant inypical ngezenzo ezahlukeneyo, ngokugqithiseleyo kwi-glutamatergic system. Iyalumkisa ukukhululwa kwe-glutamate kwaye ihlengahlengisa umsebenzi we-AMPA receptor. I-tianeptine iphinda ibe njenge-agonist ye-μ-opioid receptor (EC50s = 194 kunye I-641 nM yamkeli yeziluntu kunye nemouse, ngokulandelanayo). Kusebenza ngendlela efana ne-fluoxetine ekulawuleni inkathazo yoxinzelelo emva kwesifo.

I-Tianeptine ityuwa yesodiyam inesakhono se-nootropic ngokubhekisele kubantu abanokuchaphazeleka okungalunganga okuchaphazeleka kukuphazamiseka kwemood kwaye banako ukuphucula ukugxila kunye nokugxila kubantu abangajonganga kakuhle.

I-Tianeptine i-sodium ityuwa yomgubo (30123-17-2) Indlela yokuSebenza

Uphononongo olutshanje lubonisa ukuba i-tianeptine yenza njenge-agonist ngokupheleleyo kwi-mu-type receptor ye-opioid (MOR). I-Tianeptine inselele i-monoaminergic hypothesis yexinzelelo, kunye neendlela ezixhaswa ngokubanzi ezixhaswa yi-monoaminergic apho i-action ye-anti-depressants eyaziwayo ichazwe. Ngokukodwa, eli chiza kucatshangelwa ukuba liqhubeke liguqula i-glutamate receptor ukugqitywa kwe-hippocampal ye-hippocampal ye-CA3 ye-synapse enobudlelwane. Uphando lwangoku lubonisa ukuba i-tianeptine ivelisa iziphumo zayo ezixinzelelekayo ngokumodyuli ye-glutamate receptor (umzekelo, i-AMPA receptors kunye ne-NMDA receptors) kwaye inokuchaphazela ukukhululwa kwengqondo ye-neurotrophic (BDNF) eyenza ingqondo ye-brain. Uphando olutshanje luxhasa ngenkxaso ye-tianeptine kwindlela yokumodareyitha yomsebenzi we-glutaminergic kwi-amygdala, kwingingqi yomzwelo yengqondo ehambelana nezikhumbuzo.

I-Tianeptine inciphisa i-hypothalamic-pituitary-adrenal response kwi-stress, kwaye ngaloo ndlela ikhusela imiba yokuziphatha yokuxininisa. Ngeentonga, uxinzelelo lwe-stroke ekhulayo lwandisa amazinga angaphezulu kwe-glutamate kwi-amygdala ye-basolateral eyimpembelelo eyayivinjelwe yi-tianeptine. Ngokuthakazelisayo, i-SSRI fluoxetine yandisa amanqanaba e-glutamate e-extracellular kwi-amygdala ye-basolateral kungakhathaliseki ukuba imeko yokuxinwa. Ezi nkcukacha zibonisa ukuba indlela yokwenza i-tianeptine ihluke kwi-SSRIs kwaye ixhasa ingcamango yokuba indlela yokusebenza ye-tianeptine ihambelana nokuguqulwa komsebenzi we-glutaminergic kwi-amygdala kunye ne-hippocampus.

Ukongeza kwindlela ezi ngasentla, i-tianeptin yinto ekhethekileyo yokuxhatshazwayo kunye ne-anxiolytic imithi ekhuthaza ukufunyanwa kwe-serotonin (i-5-hydroxytryptamine; i-5-HT), kunye ne-5-hydroxyindoleacetic acid (i-5-HIAA) kwiisishu zobuchopho.

Nangona i-serotonin ye-monoaminergic neurotransmitter (i-5-HT), i-noradrenaline (NA) kunye ne-dopamine (DA) iboniswe ukuba ihambelana nokuvela kweengxaki zokudandatheka, ngoku kuyaqaphela ukuba ukulahlekelwa kwe-monoamine akwanele ukucacisa indlela yokwenza izinto ezixhasayo mayeza.

benefits of Tianeptine i-sodium ityuwa yomgubo (30123-17-2)

  • I-Tianeptine ityuwa yesodium inokuphatha ingxaki enkulu yokudandatheka.
  • I-Tianeptine ityuwa yesodiyam ine-anti-ixhala kunye noxinzelelo kunye neempawu ze-nootropic.
  • I-Tianeptine ityuwa yesodium ikhuthaza isimo sengqondo kunye nokuphucula isimo sengqondo.
  • I-Tianeptine ityhudi yesodium inokubangela ukuhlaselwa kwesoyiko.
  • I-Tianeptine i-sodium ityuwa yiphatha intlungu enxulumene ne-fibromyalgia.
  • I-Tianeptine sodium ityuwa esetyenziswa kunyango lokudakumba kwamadoda anokungasebenzi kakuhle.
  • I-Tianeptine ityuwa yeryudidi ine-efficacy ecacileyo kwi-ADHD.
  • I-Tianeptine ityuwa yesodium inokukhuthaza i-neuroplasticity.

kucetyiswa I-Tianeptine i-sodium ityuwa yomgubo (30123-17-2) Isisombululo

I-Tianeptine Sodium ine-half-life life short about 2.5 iiyure14, kwaye idinga ukuphindwa kabini kwimihla. I-tianeptine ye-sodium dosage i-12.5 mg ithathwa kathathu ngosuku, i-37.5mg ngosuku.

Musa ukudlula i-50mg ye-Tianeptine Sodium ngosuku olunye. Ukwenza njalo kunokuvula umnyango wokusetyenziswa kakubi nokusetyenziswa komlutha.

Imiphumela I-Tianeptine i-sodium ityuwa yomgubo (30123-17-2)

I-Tianeptine ityiwa yetyuwa yomgubo inxibelelana namalungu amaninzi obuchopho kubandakanya ii-opiod receptors, ezinokuthi zenze umphumo wecala lokuvuya. Ezinye iziphumo ebezingalindelekanga ezihamba rhoqo zibandakanya oku kulandelayo:

 Intloko (ukuya kwi-18%)

 Utywala (ukuya kwi-10%)

 Ukuphazamiseka / ukuphazamiseka ebusuku (ukuya ku-20%)

 Ukulala (ukuya ku-10%)

 Umlomo omile (ukuya kwi-20%)

Ezinye iziphumo ebezingalindelekanga zibandakanya izinto ezifana nokuqhinwa, isicaphucaphu, ixhala okanye iTyhefu yetyhefu. Iinkxalabo ezibi kakhulu zibandakanya ukurhoxa emva kokuphathwa gadalala kunye ne-0.1 - 0.3% yabasebenzisi abaya kuba nale ngxaki. Kuze kube nini, njengoko ubona, iziphumo ebezingalindelekanga zetyuwa ye-sodium yeTianeptine ziya kuxhomekeka kubuchwephesha bomntu kunye nobuntu.

Kufuneka ukuba uqaphele ukuba:

Izigulane ezindala kufuneka zithathe umthamo omncinci weTyaneptine ityuwa yeryudi, njengokuba kufuneka izigulane zokungaphumeleli komntu. Isisombululo asidingeki ukuba iguqulwe kwizigulane ezinobunxila okanye ukuphazamiseka kwesifo, okanye izigulane kwi-dialysis .Nakuba i-Anti-depressants, njenge-tianeptine, yandise umngcipheko wesifo sobungozi besibindi.