I-Sodium (GM1) yengqondo yengulube (37758-47-7) i-Monosialotetrahexosylganglioside

Ngamana 28, 2019

I-GM1 powder isetyenziswe ngokubanzi ukunyanga ukulimala kwengqondo ye-neonatal hypoxic-ischemic, isifo sika-Parkinson ...

 


Isimo: KwiMveliso yoLuntu
I-Synthesized and Customized Available
Amandla: 1277kg / inyanga

 

I-sodium (GM1) yengqondo yengulube (37758-47-7) yevidiyo ye-Monosialotetrahexosylganglioside

 

I-Sodium (GM1) yengqondo yengulube (37758-47-7) Inkcazelo ye-sodium (GMXNUMX)

I-Monosialotetrahexosylganglioside Sodium (GM1) ingqondo yehagu (37758-47-7), igama elifutshane linokuba yi-GM1, ekhutshwe kwingqondo yehagu kwaye lilungu leqela le-ganglio ye-gangliosides equlathe intsalela ye-sialic acid.

I-GMl inokukhuthaza ukubuyiswa kwemisebenzi yengqondo emva kokulimala kwinkqubo yesistim ephakathi kwezinto ezihlukahlukeneyo, ukukhuthaza i-neuroplasticity. Iingcamango zibonisa ukulimala kweengqondo ze-GMl ze-brain, ubuchopho obubuhlungu bokubuyisela iiseliti zesigulane kumonakalo wentambo yomgudu kunomphumo wokukhusela kwaye kukhuthaza inxaxheba yeseli.

Isigaba sangaphambili sesigaba sesi-2 sesilingo sonyango sibonisa, sinokunciphisa i-nealtoxicity (OIN) ye-oxaliplatin. Kodwa ayizange iqinisekiswe isilingo sesigaba III. Uvavanyo lwesigaba III lufunekayo ukuphanda umphumo kunye nokukhuselwa kwe-sodium Injection ye-monosialotetrahexosylganglioside yokukhusela i-OIN kwisifo somhlaza.

I-sodium (GM1) yengqondo yengulube (37758-47-7) Specifications

Igama lemveliso I-Sodium (GM1) yengqondo yengqondo ye-Monosialotetrahexosylganglioside
Igama leKhemikhali Isodium ye-Monosialotetrahexosylganglioside (Ingqondo yePorcine)

Okanye i-GM1

Ukulandelelana /
uhlobo Numama Shenjie
Iqela leziyobisi Sphingolipids
Inani leCAS 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
I molecular Fi-ormula C73H134N4O31
I molecular WSibhozo 1563.85
IMasaisotopic Mass 1563.85
Ukuxuba Point  N / A
I-Biological Half-Life /
umbala I powder ephilileyo engapheliyo
Umzimba  i-chloroform / i-methanol (i-9: i-1): i-10 mg / mL, icacile, ingenambala
yoGcino Tukushisa  -20 ° C
Aukuguquka Iimvume zokufumana i-toilin ye-k'holera eqokelela kwingqondo ekupheleni kwe-lipidosis.
Izinto zokuvavanya KwiNdlu Imigangatho yoLunga
Chauhlanga Umpu omhlophe okanye omhlophe; iyanuka, ayinambitha; emanzi. Le mveliso inqabile emanzini, ichithwe kakhulu kwi-methanol, phantse i-ethanol ene-anhydrous.
Uchonga
Umbala wokuphendula umbala 1 Thabatha isisombululo se-0.2ml phantsi kokuzimisela komxholo, engeza amanzi 2ml, uze wongeze isisombululo se-Hydroquinone hydrochloric acid (i-hydroquinone 0.2g, yongeza amanzi 10ml, yongeza i-hydrochloric acid 90ml, yongeza i-0.1mol / L I-sulfate isisombululo 0.25ml, i-friji Preservation) 2ml, Ukuhlambela ngamanzi okutshisa imizuzu ye-15, isisombululo esibhakabhaka kunye nemfusa, kunye ne-alcohol engeyiyo 5ml Ukukhutshwa kwe-vibration, ukungabi nendawo yokusela utywala.
Umbala wokuphendula umbala 2 Thatha le mveliso malunga ne-20mg, faka i-glacial acetic acid 1ml, ibhedi yamanzi ashushu atshisa ngokupheleleyo, udibanise ezintathu ze-chloride ukuhlolwa kwamanzi amanzi e-1, emanzini ashushu ajikelezayo kunye nodonga lombhobho ngokukhawuleza wongeza i-sulfuric acid 1ml, ukuze isisombululo sibe ngamacandelo amabini , i-interface-liquide yombane kufuneka ibe mnyama
Ityuwa Ukuchongwa kwe-sodium yetyuwa kule mveliso (i-Chinese Pharmacopoeia i-2015 edition ye-0301).
I-chromatography yamanzi (LC) Kwigrafu ye-chromatographic ebhalwe phantsi kokuzimisela kokuqukethwe, ixesha lokugcinwa kweyona nto ephambili yesisombululo sokuvavanya kufuneka ihambelane nexesha lokulondoloza kwinqanaba eliphambili lesisombululo sokulawula.
Ukutshatyalaliswa kwemiboniso Imephu yokuqhawula ukukhanya kwe-infrared yile mveliso kufuneka ihambelane nemephu yolawulo lwemveliso (i-Chinese Pharmacopoeia 2015 edition ezine 0402).
Hlola
PH 5.0 ~ 6.5
Ukucaca kunye nombala wesisombululo Kufuneka icaciswe ngokungenambala; ukuba ifufayo, ayiyi kuba yimbi kunomlinganiselo osemgangathweni we-turbidity No. 1th; Ukuba ukulungiswa kombala akufanele kube yinkcazo kunokuba isisombululo se-YellowName 1th isisombululo.
Ukunyanzela ukunyanzezela Isisombululo esipheleleyo kufuneka sibe necacileyo kwaye sibala emva kokushisa okuphezulu, kungekho ubisi obukhanyayo, akukho mvula
Isizathu sokuqinisekisa (iiprotheyini ezihlukeneyo) ≤50000
Iyonke i-asialic acid Ngokutsho kokubala komkhiqizo owomileyo, i-saliva equkethe i-acid kufuneka ibe yi-19.0 ~ 21.0%
Izinto ezinxulumene nazo I-asialic acid ≤0.3%; GD3, GD1a, ukungcola okungaziwa ≤ 0.5%; ukungcola kunye ≤2.0%
protein ≤1.0%
Ubunzima be-molecular weight ≤0.5%
Izixazululo zokuhlala I-Methanol ≤ 0.1%; i-acetone ≤ 0.3%; Trichloromethane ≤0.003%
amanzi ≤4.0%
Ukutshisa okutshayo ≤5.0%
Intsimbi enzima ≤20ppm
Ubunobumba obubi Ukuthobela iMimiselo
Izinto ezincinci Kufuneka ukuba ngokuhambelana nemimiselo (ubuninzi beendlela zokulawula)
Iiprojeni Kufuneka ukuba ngokuhambelana nemimiselo (ubuninzi beendlela zokulawula)
Imida ye micimbi Inani elipheleleyo leebhakteria ze-aerobic kufuneka libe <100cfu / g, kwaye inani lilonke lomngundo kunye neigwele kufuneka libe <50cfu / g
Ecacileyo ≥98.0%

 

ekrwada I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  powder (37758-47-7) Inkcazelo

I-sodium ye-Monosialotetrahexosylganglioside (37758-47-7), igama elifutshane linokuba yi-GM1, elikhishwe kwingqondo yengulube kwaye ilungu lechungechunge le-gangliosides eliqulethe i-aseic acid asele.

I-GM1 inokukhuthaza ukubuyiswa kwakhona kwemisebenzi ye-neurological emva kokonzakala kwenkqubo ye-nervous system yezizathu ezahlukeneyo, ukukhuthaza i-neuroplasticity. Uvavanyo lubonisa ukonzakala kwengqondo ye-GM1 ye-vascular, ingqondo eyenzakalisayo yokubuyisela iiseli zemithambo-luvo kumonzakalo wentambo yomqolo inefuthe lokhuselo kunye nokukhuthaza indima yeseli.

Isigaba sangaphambili sesigaba sesi-2 sesilingo sonyango sibonisa, sinokunciphisa i-nealtoxicity (OIN) ye-oxaliplatin. Kodwa ayizange iqinisekiswe isilingo sesigaba III. Uvavanyo lwesigaba III lufunekayo ukuphanda umphumo kunye nokukhuselwa kwe-sodium Injection ye-monosialotetrahexosylganglioside yokukhusela i-OIN kwisifo somhlaza.

I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Inkqubo yezenzo?

I-GM1 (monosialotetrahexosylganglioside) i "prototype" i-ganglioside, lilungu le-ganglio uthotho lwee-gangliosides eziqulethe intsalela enye ye-sialic acid. I-GM1 ineempawu ezibalulekileyo zomzimba kunye nefuthe leplastiki ye-neuronal kunye neendlela zokulungisa, kunye nokukhululwa kwee-neurotrophins kwingqondo. Ngaphandle komsebenzi wayo kwi-physiology yengqondo, i-GM1 isebenza njengendawo yokubopha ityhefu yekholera kunye no-E.

benefits of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  powder (37758-47-7)

I-Ganglioside GM1 ilungu leentsapho zegriyoside esetyenziswe kumazwe amaninzi kwaye kucatshangelwa njengonyango oluthembekileyo lokukhusela izifo ezininzi ze-neurological, ezibandakanya ukulimala kwe-cerebral ischemic. Iimpembelelo zokwelapha ze-GM1 ziye zabonakaliswa zombini kwi-neonates nakubantu abadala emva kokulimala kwengqondo yobuchopho.

kucetyiswa I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ipowder (37758-47-7) Isistim

Iyeza lalilawulwa ngedosi ye-20-40 mg yonke imihla ngenaliti efakwa ngaphakathi okanye efakwa kancinci kwimisipha ngokweengcebiso zikagqirha. Kwisigaba esibuhlungu sokutshintsha kwe-pathological: Iyeza lalisetyenziswa kwidosi ye-100 mg yonke imihla ngenaliti efakwa ngaphakathi; Emva kweeveki ezi-2-3, kugcinwa isixa esingama-20-40 mg yonke imihla kangangeeveki ezintandathu, idosi yokuqala ye-500-1000 mg yayilawulwa kukudinwa ngemithambo yesifo sikaParkinson; Ukusukela kusuku lwesibini, ichiza lalisetyenziswa kunye nedosi ye-200 mg mihla le ngokufakwa kwesitofu, ngenaliti ye-intramuscular okanye kwi-intravenous drip kwiiveki ezili-18 ngesiqhelo. xa eli chiza lalilawulwa ngenaliti engaphantsi okanye efakwa ngaphakathi, kufuneka inyibilikiswe kwaye ihlanjululwe emanzini ngenaliti kude kube kukuxinana kwe-10 mg / ml kwi; xa i-intravenous drip, ichiza belingathandwa kwaye lihlanjululwe kwi-0.9% yenaliti ye-sodium chloride okanye i-5% inaliti yeglucose.

Imiphumela of I-MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) ipowder (37758-47-7)

Impembelelo yecala le-GM1 powder ngokuyinhloko isabela ngokukhawuleza emva kokusetyenziswa.