IAnandamide (AEA) (94421-68-8)

Matshi 15, 2020

I-Anandamide, ekwabizwa ngokuba yi-N-arachidonoylethanolamine (AEA), yi-fatty acid neurotransmitter ethathwe kwi …… ..

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

Anandamide (AEA) (94421-68-8) ividiyo

IAnandamide (AEA) (94421-68-8) Suqobo

Igama lemveliso Anandamide (AEA)
Igama leKhemikhali I-Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

Inani leCAS 94421-68-8
InChIKey I-LGEQQWMQCRIYKG-DOFZRALJSA-N
SMILE CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
I-Molecular Formula C22H37NO2
Isisindo somzimba 347.53
IMasaisotopic Mass 347.282429 g / mol
Indawo yokunyibilika N / A
Point yo kubilisa 522.3 ± 50.0 ° C (Kuxelwe kwangaphambili)
mninzi I-0.92 g / mL kuma-25 ° C (ilitha)
umbala ophuzi okhanyayo
Sitempile yetanki -20 ° C
Umzimba I-ethanol: inyibilika
isicelo Isetyenziselwa imemori, ukushukumiseka, iinkqubo zengqondo, ulawulo lwentshukumo, ulawulo lweentlungu, umdla wokuvuselela umdla kunye nokuzala.

 

Yintoni i-Anandamide (AEA)?

I-Anandamide, ekwabizwa ngokuba yi-N-arachidonoylethanolamine (AEA), yi-fatty acid neurotransmitter ethathwe kwi-non-oxidative metabolism ye-eicosatetraenoic acid (arachidonic acid. Inesakhiwo esifana kakhulu neso se-tetrahydrocannabinol, indawo esebenzayo ye-cannabis. Ukuthotywa ikakhulu yi-fatty acid amide hydrolase (FAAH) enzyme, eguqula i-anandamide ibe yi-ethanolamine kunye ne-arachidonic acid, Okokugqibela, i-Anandamide idityaniswe kwi-neuron ngokuphendula okwenzeka phakathi kwe-arachidonic acid kunye ne-ethanolamine phantsi kolawulo lwe-calcium ion kunye ne-cyclic monophosphate adenosidase. Sisandulela seqela lezinto ezisebenza ngokwasemzimbeni (iProstamides) ezidlala indima kwizinto ezininzi zomzimba, kubandakanya ukutya, inkumbulo, iintlungu, uxinzelelo kunye nokuzala.Ukongeza, i-Anandamide ikwathintela abantu Ukwanda kweeseli zomhlaza wamabele.

I-Anandamide ikhona kwizinto ezininzi eziphilayo, ezinjenge-urchin roe yolwandle, iingqondo zehagu kunye nezibindi zeempuku, njl, kodwa inani lalo lincinci. Kwakhona, abaphandi bafumanise iAnandamide kunye nezinto ezimbini (N-oleoylethanolamine kunye ne-N-Linoleylethanolamine) kwitshokholethi emnyama. I-Anandamide ikwakhona kwezinye iinkozo ezicutshungulwayo, (isonka esimhlophe), Utywala (ngakumbi, ukusetyenziswa okungapheliyo okanye ukusela kakhulu), iswekile ecoliweyo, amafutha eTrans, Ukutya okuthosiweyo kwioyile yemifuno kunye nokutya okungengokwakho okunemichiza yokubulala izitshabalalisi njl.

Njengenxalenye yenkqubo ye-endocannabinoid (ECS), i-Anandamide ichongwa njengomlawuli we-homeostasis kunye nolunye udidi lwe-cannabis-efana ne-2-AG ye-cannabinoid receptors emzimbeni wonke. Le nkqubo ikhona kuzo zonke iirtebrates. I-Anandamide idlala indima yokulawula indlela yokutya kunye neurogenic yenkuthazo kunye nolonwabo, ukugcina imizimba yethu kunye nengqondo zilungelelene. Izifundo zifumene ukuba iimvakalelo zethu, ulonwabo, uloyiko, ixhala, kunye nokukwazi ukumelana noxinzelelo zonke zilawulwa yinkqubo ye-endocannabinoid, kunye nezifo ezahlukeneyo ukusuka kwi-schizophrenia ukuya kuxinzelelo zihamba kunye namanqanaba angaqhelekanga e-anandamide.

I-Anandamide, efanayo ne-THC, yinxalenye ye-agonist ye-CB1R. Inokubangela ukuphuculwa okunokubakho ngokusebenza okupheleleyo kwengqondo. Kubalulekile ukuba uqaphele ukuba zonke ezi ziphumo ze-Anandamide zibonakala ngathi ziyaphuculwa ngenxa ye-pharmacologically ethintela ukuthotywa kwayo. Ukufunyanwa kuka-Anandamide kunokukhokelela kuphuhliso losapho olutsha ngokupheleleyo lweziyobisi zonyango.

 

Izibonelelo ze-Anandamide (AEA)

I-Anandamide, ekwabizwa ngokuba yi "molekyuli yolonwabo", sisomelezi semood, i-neurotransmitter kunye ne-endocannabinoid, enezibonelelo ezininzi zempilo nezengqondo:

I-Anandamide inciphisa ukwakhiwa ngokukhawuleza kweeseli zomhlaza. Ngo-1998, iqela leenzululwazi zase-Italiya lafumanisa ukuba i-anandamide inokunyusa i-neurogeneis kwaye yenze iiseli zemithambo emitsha, ngokuthe ngcembe ukwakheka / ukunyusa ixabiso leseli yomhlaza webele.

Ukukwazi kuka-Anandamide ukukhuthaza i-neurogeneis (ukuyilwa kwee-neurons ezintsha) kudlala indima kulawulo lokuziphatha kunye nokukhuthaza inkuthazo kunye nolonwabo kwiimpuku. Oku kunceda ukunciphisa iimpawu zoxinzelelo kunye noxinzelelo. Isifundo ngo-2015 sabantu kunye neempuku ezifumanise ukuba amanqanaba aphezulu e-anandamide anokukhuthaza ukuphucula imood kunye nokwehlisa uloyiko.

Ukongeza, ukubanakho kwe-anandamide ukubopha kwi-CB1 kunye ne-CB2 receptors ziya kuchaphazela kakhulu iindlela ezininzi zomzimba, zibonisa izibonelelo ezilungileyo kwimemori, inkuthazo, iinkqubo zokuqonda, ulawulo lokuhamba, ulawulo lwentlungu, ukukhuthaza ukutya kunye nokuzala.

 

Ungayonyusa njani i-anandamide(AEA) amanqanaba emzimbeni womntu?

Ngenxa yokuba i-anandamide inendima ye-neurotransmitter, iarhente ye-vasodilator kunye ne-serum metabolite yegazi lomntu, kunye nezibonelelo zezempilo kunye nezengqondo ezibonisiweyo, unokufuna ukwandisa inqanaba le-anandamide emzimbeni wakho. Nazi ezinye zeendlela zokwandisa amanqanaba e-anandamide okwethutyana emzimbeni womntu:

- Imithamboba

Uphononongo lufumanise ukuba emva kwemizuzu engama-30 kuphela yokusebenza, i-anandamide (AEA) yomxholo wabantu kunye nezinja inyuke. Ke ukuba ufuna ukufumana eyona nzuzo, yenza umthambo rhoqo.

- Ukutya itshokholethi emnyama

Itshokolethi emnyama inenxalenye ephezulu ye-theobromine kwitshokholethi esempilweni, kwaye i-theobromine inceda ukwandisa imveliso ye-anandamide kwingqondo kwaye iye icothise ukuwohloka kwayo okwethutyana.

- Ukutya i-truffle emnyama

I-truffle emnyama (isikhunta esimnyama) ngokwemvelo iqulethe i-anandamide. Nangona le fungus ingenako ukusebenzisa i-anandamide nangayiphi na indlela, abaphandi bakholelwa ukuba isetyenziselwa ukutsala izilwanyana ukuba ziyitye kwaye ivelise kwakhona amabala ayo.

-Ukujolisa

Uphando lubonisa ukuba xa umntu ekwisimo (esibizwa ngokuba "sihamba" okanye "kwingingqi,") yoxinzelelo oluphezulu, ukusebenza, kunye noxinzelelo, ayizukuphela nje ukuba ube nemveliso ngakumbi okanye wenze imisebenzi engcono kwingqondo yakho. Inani elikhulu leekhemikhali, ezinje nge-serotonin, i-dopamine, i-endorphin kunye ne-anandamide.

Ngaphezu koko, iti, i-coriander kunye ne-celery inokunceda ukwandisa imveliso ye-anandamide.

 

Imbekiselo:

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  • U-El-Talatini MR, Taylor AH, Konje JC (Epreli 2010). "Ubudlelwane phakathi kwamanqanaba e-plasma ye-endocannabinoid, i-anandamide, i-sex steroids, kunye ne-gonadotrophins ngexesha lokuya esikhathini". Ukuchuma. Steril. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. IINKCUKACHA:
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