I-rough Lorcaserin HCL powder (846589-98-8)

Oktobha 30, 2018

I-Raw Lorcaserin i-hydrochloride powder yi-serotonin 2C (5-HT2C) i-receptor agonist kunye neyeza ezilawulwa ngomlomo ezikhuthaza ...


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1380kg / inyanga

I-powder Lorinerin HCL powder (846589-98-8) ividiyo

 

I-powdered Lorcaserin HCL powder (846589-98-8) Iinkcukacha

Igama lemveliso I-Lorcaserin Hydrochloride powder
Igama leKhemikhali I-rough Lorcaserin HCL powder, iLorcaserin
uhlobo Numama BELVIQ
Iqela leziyobisi I-5-HT2C i-receptor inhibitor
Inani leCAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
I molecular Fi-ormula C11H15Cl2N
I molecular WSibhozo 232.15
IMasaisotopic Mass 231.058154899
Ukuxuba Point  Akukho datha ekhoyo
Fukuhlaziywa kwakhona Point Akukho datha ekhoyo
I-Biological Half-Life Isiqingatha-ubomi se-lorcaserin malunga neeyure ze-11. I-powcaserin powder ipheliswa ngokuyinhloko kumchamo (i-92%) kunye nakwinkomo (2.2%)
umbala Powder
Umzimba  Ubuncwane bamanzi: 0.0709 mg / mL
yoGcino Tukushisa  -20 ° C.
Aukuguquka I-Serotonin 2C (HT2C) i-agonist ye-receptor yokulahleka kwesisindo.Ikhetha ukusetyenziswa kokutya kwaye ikhuthaze i-satiety centrally

 

I-rough Lorcaserin Hcl powder (846589-98-8) Inkcazo

I-Raw Lorcaserin i-hydrochloride powder yi-hydrochloride efunyenwe ngokuphendula kwe-lorcaserin powder kunye ne-hydrochloric acid efanayo. Isetyenziswa njengechiza elichasene nokukhuluphala. I-Lorcaserin hydrochloride yi-5HT2c receptor agonist eboniswe ukuba isetyenziswe kubantu abadala abane-BMI -30, okanye abo bane-BMI -27 kwaye ubuncinci imeko enxulumene nobunzima njengoxinzelelo lwegazi, uhlobo lwe-2 yeswekile okanye idyslipidemia. inciphisa uvakalelo lokuhlutha, kwaye kucingelwa ukuba kuthintela ukuvela kwesifo se-valvular yentliziyo enxulunyaniswa nokusebenza kwe-5-HT2B receptors, indawo yengqondo eyaziwa ukuba idlale indima enkulu kulawulo lwendlala kunye nokutya. Ngokusebenzisa ezi receptors, iLorcaserin hydrochloride powder inokunciphisa ukusetyenziswa kokutya ngokunciphisa ukutya kwaye yenze umntu azive egcwele nokuba sele etye ukutya okuncinci kunesiqhelo. yamkelwe namhlanje yi-FDA kwisigqibo esimangalisayo emva kweminyaka emi-2 yokuphononongwa.

I-Lorcaserin hydrochloride powder ibonakaliswe ngokukodwa njengendlela yokunciphisa ukutya okunokunciphisa-khalori kunye nokunyuka komzimba okwenziwe ukulawula ukunyuka kwamayeza kubantu abadala (i-BMI ye-30 kg / m2 okanye ngaphezulu) kunye nabantu abadala kakhulu (i-BMI ye-27 kg / m2 okanye ngaphezulu) ubuncinane ubunzima obunxulumene nesisindo.

I-Lorcaserin hydrochloride powder isetyenziselwa kunye nokutya kunye nokuzivocavoca ukuphatha ukukhuluphala. Ngamanye amaxesha kusetyenziswa ukuphatha ukukhuluphala okunokuthi kuhlobene nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.

I-Lorcaserin hydrochloride ayiyi kunyanga nayiphi na imeko yezempilo (njengentliziyo yesifo, isifo sikashukela, uxinzelelo lwegazi). Qhubeka uthatha nayiphi na enye imichiza ugqirha wakho oye wachaza ukuphatha le miqathango.

I-Lorcaserin Hcl powder (846589-98-8) Indlela yokusebenza

Nangona indlela echanekileyo ingaziwa, kukholelwa ukuba kuququzelele ukukhetha okukhethayo kwe-5-HT2C i-receptors kwi-anorexigenic pro-opiomelanocortin neurons kwi-nucleus ene-hypothalamus. Oku kuphumela ekunciphiseni ukutya nokutya ngokunciphisa ukukhululwa kwe-alpha-melanocortin i-hormone ekhuthaza, eyenzeka kwi-melanocortin-i-4 receptors.

I-Lorcaserin hydrochloride powder isebenza ngokulawula ukutya-ngakumbi ngokwenza i-brain receptors ye-serotonin, i-neurotransmitter eyenza iimvakalelo zokuhlutha kunye nokwaneliseka. Ukungeniswa kokutya kulawulwa liziko lokuhlutha, elibekwe kwi-ventromedial nucleus ye-hypothalamus kunye nendawo yokulamba ekhoyo kwi-hypothalamus esecaleni. Amagalelo ahlukeneyo avela kumaziko aphezulu kunye neephecana zesisu ziyahlangana kwi-arcuate nucleus, apho zimbini iintlobo ze-neurons ezilawula ukutya okhoyo. Okokuqala, iqela lokutya elikhuthazayo elivelisa ukutya elivelisa i-agouti protein kunye neuropeptide Y; Okwesibini, ukutya ukutya iqela eline-cocaine kunye ne-amphetamine elawulwayo (CART) kunye ne-pro-opiomelanocortin (POMC) neurons. I-POMC iqulethe ii-receptors ze-5-HT 2C, ezithi xa zenziwe zasebenza zikhuphe i-alpha-melanocyte-evuselelayo yehomoni (alfa-MSH) .Zombini izithintelo kunye nezivuseleli ze-neuron ziqhubela phambili iiprojekthi ze-nucleus yenyani kwi-hypothalamus. I-Paraventricular nucleus iqulethe i-melanocyte 4 receptors (MC4R) ethintela ukutya kwiidosi zonyango i-lorcaserin hydrochloride powder esebenza njenge-5-HT 2C agonist kwi-POMC neurons, ethi yona ibangele ukukhutshwa kwe-alfa MSH. Ukuqhubeka kwe-alfa i-MSH isebenza kwi-MC4R kwi-nucleus yeparadricular kwi-hypothalamus, ekhokelela ekwehliseni umdla wokutya. Kwiidosi ze-supratherapeutic, i-lorcaserin hydrochlorider ikwasebenza kwi-5-HT 2B kunye ne-5-HT 2A receptors.

benefits I-Lorcaserin Hcl powder (846589-98-8)

  • I-Lorcaserin HCL powder yi-5-HT2C i-receptor agonist ecinga ukuba iyancipha ukunciphisa ukutya ngokusebenzisa inkqubo yePOMC ephakathi. Inzuzo yefowuni yeLorcaserin HCL:
  • I-Lorcaserin HCL powder isetyenziselwa kunye nokutya kunye nokuzivocavoca ukuphatha ukukhuluphala.
  • Ngesinye isikhathi i-Lorcaserin i-HCL powder isetyenziselwa ukunyanyisa ukukhuluphala okunokuthi kunxulumene nesifo sikashukela, i-cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.
  • I-Lorcaserin HCL powder ayiyi kunyanga nayiphi na imeko yezempilo (njengentliziyo yesifo, isifo sikashukela, uxinzelelo lwegazi).

Ukuphakanyiswa kwe-Lorcaserin Hcl powder (846589-98-8) Isisombululo

I-Lorcaserin HCL powder iza kwifom ye-tablet kwaye ithathwa ngamaxesha angama-1-2 ngosuku, kunye okanye ngaphandle kokutya. I-Lorcaserin kufuneka isetyenziswe kunye nokunciphisa ukutya kweekhalori kunye nesicwangciso sokuzivocavoca.

Umthamo ocetyiswayo we-lorcaserin hcl powder yi-10 mg elawulwa ngomlomo kabini ngosuku. I-Lorcaserin inokuthathwa ngaphandle kokutya. I-Lorcaserin hcl kufuneka iyekwe kwizigulana ezingaphumeleliyo ukufezekisa ubuncinci i-5% yokulahleka kwesisindo ngeveki ye-12 kuba abaguli abanakufumana ilahleko enesisindo ngokuqhubeka nokunyanga.

Imiphumela I-Lorcaserin Hcl powder (846589-98-8)

I-Lorcaserin Hcl powder isetyenziselwa unyango lokulawula ubunzima obungapheliyo kubantu abadala abane-index mass mass (BMI) ye-30 okanye ngaphezulu (ukutyeba kakhulu) njengokongeza kwi-calorie yokutya kunye nokuzivocavoca. Ikwavunyiwe ukuba isetyenziswe ngabantu abadala abane-BMI engama-27 okanye ngaphezulu (ukutyeba kakhulu) kwaye abanesimo esinye esimalunga nobunzima esifana noxinzelelo lwegazi (uxinzelelo lwegazi), okanye i-cholesterol ephezulu (i-dyslipidemia). Nangona kunjalo, inokuba neziphumo ebezingalindelekanga. Njengasezantsi:

 Tiziphumo eziqhelekileyo ezichaphazelekayo:

  • -Ukufunda,
  • -Izakhono,
  • -Ukuxhatshazwa,
  • -Ngenxa,
  • -Sula umlomo,
  • -Isivumelwano, kunye
  • - I-hepoglycemia (ushukela wegazi ophantsi).

 Ezinye iziqhelo ezingekho phantsi kodwa ezibi kakhulu ezinxulumene ne-lorcaserin ziquka:

  • -Qala iingxaki zeviniki,
  • -Changisisa kwingqalelo okanye kwimemori,
  • -Engxaki zeengqondo,
  • Ukuxhatshazwa okanye iingcinga zokuzibulala,
  • -Ukuphazamiseka,
  • -Injabulo yentliziyo,
  • -Ukuhla kwe-cell cells count, kunye
  • - Ukwanda kwehomoni, iprolactin.