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USulforaphane (4478-93-7)

Isulforaphane, ekwabizwa ngokuba yi "dl-sosforaphane", sisityalo sendalo esifumaneka kwimifuno emininzi ecekeceke njenge …………… ..


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

inkcazelo

ISulfrafa Suqobo

Igama lemveliso ISulfrafa
Igama leKhemikhali Sulforafan
DL-Sulforaphane
I-1-Isothiocyanato-4- (methylsulfinyl) butane
D, L-Sulforaphane
uhlobo Numama N / A
Iqela leziyobisi Imigangatho; Ii-Enzyme activators kunye nee-Inhibitors;
Inani leCAS 4478-93-7
InChIKey I-SUVMJBTUFCVSAD-UHFFFAOYSA-N
I molecular Fi-ormula C6H11NOS2
I molecular WSibhozo 177.3 g / mol
IMasaisotopic Mass 177.028206 g / mol
Indawo yokubilisa 125-135 ° C
Fukuhlaziywa kwakhona Point N / A
I-Biological Half-Life N / A
umbala lubhelu
Sukufaneleka I-DMSO: inyibilikisiwe 40 mg / mL
Sisibetho Tukushisa -20 ° C
Aukuguquka I-Sulforaphane powder ikakhulu isebenza kwizongezo.

Iyintoni iSulfrafa?

ISulforaphane, ekwabizwa ngokuba yi- "dl-sosforaphane", sisityalo sendalo esifumaneka kwimifuno emininzi ene-broccoli, iklabishi, ikholifulawa, kunye ne-Kale.

Yinto antioxidant exhaphakileyo kunye nesona sityalo sisebenzayo sifumaneka kwimifuno. I-Sulforaphane ayinamsebenzi owomeleleyo wokulwa nomhlaza, kodwa ikwanamandla okulwa ne-oxidation. Iyaziwa njengenye yeemveliso zendalo ezinokulwa nomhlaza kunye nemiphumo yobuhle.

I-Sulforaphane iveliswa xa i-enzyme myrosinase eguqula iglucoraphanin, iglucosinolate, ibe yi-sulforaphane ngomonakalo wesityalo (njengokuhlafuna), ovumela iikhompawundi ezimbini ukuba zixube kwaye zisabele. Amagqabi amancinci e-broccoli kunye ne-cauliflower atyebile ngakumbi kwi-glucoraphanin kunye ne-sulforaphane.

I-Sulforaphane (SFN) yi-isothiocyanate, isodium enezinto eziphilayo. Isulforaphane ekhuphe umgubo une-antioxidant, i-antimicrobial, anticancer, anti-immune, anti-ukuguga, iipropathi ezichasene nesifo seswekile.

ISulfrafa iinzuzo

IziBonelelo zezeMpilo zeSulforaphane

Izinto zokuncedisa i-Sulforaphane azange zivunywe yi-FDA zokusetyenziswa kwezonyango kwaye ngokubanzi zingenalo uphando olomeleleyo lweklinikhi. Imigaqo imisela imigangatho yokuvelisa kubo kodwa abaqinisekisi ukuba bakhuselekile okanye bayasebenza.

  • ukukhuthaza ukudodobala
  • yandisa ingqondo
  • Ukunceda umzimba ukuba udale imichiza yokulwa nomhlaza
  • ukuxhasa ukusebenza kwentliziyo
  • Ukunyusa glutathione njenge activator ye-Nrf2
  • ukukhuthaza ukunciphisa umzimba
  • Ukucothisa ukuguga ngokwenza iiprotein zothusayo
  • Ukunyusa umsebenzi wesibindi
  • ukunciphisa ukuvuvukala kunye nentlungu
  • ukumisa kunye nokubuyisa ukulahleka kweenwele.
  • I-Sulforaphane inokunciphisa i-cholesterol ye-LDL
  • Diabetes

Ukuhluma kweBroccoli kuphucula iiparameter ezininzi zeswekile. Kwiindidi zeswekile ezi-2, ukutya i-broccoli kuhluma kwandisa amandla e-antioxidant kunye ne-HDL cholesterol, kunye nokunciphisa uxinzelelo lwe-oxidative, triglycerides, insulin, ukumelana ne-insulin, kunye ne-CRP.

  • Umonakalo wolusu

I-Sulforaphane inokubonelela ngokukhuselwa ekuchaseni kwe-UVA kunye ne-UVB, ukutshiswa lilanga, kunye nokonakala kwesikhumba.

  • I-Sulforaphane Yehlisa Iimpawu ze-Autism

I-Sulforaphane inokusebenzisa iintlobo ezithile zokukhusela iiseli ngokuchasene noxinzelelo lwe-oxidative, ukuvuvukala, kunye nomonakalo we-DNA, zonke ezi zinto zidibene ne-autism spectrum disorder.

  • Umsebenzi weAntiviral

I-Sulforaphane ibonakalise umsebenzi ongasebenziyo xa iiseli ezosulelekileyo ziveliswa ngokuthe ngqo

Iziphumo zeSulforaphane kunye nokukhuseleka.

I-Sulforaphane ikhuselekile xa isetyenziswa kwiimali ezifumaneka kukutya. Kodwa akukho lwazi lwaneleyo ukuze wazi ukuba kukhuselekile na ukuluthatha emlonyeni njengeyeza.

Sulforaphane usebenzisa kunye nokusetyenziswa

-Sulforaphane inokusetyenziselwa ukucoca iibhaktheriya eziyingozi zemiphunga.

-Sulforaphane inomsebenzi we-anti-immune kunye nokunciphisa iintlungu kwizifo samathambo.

-Sulforaphane inokuqalisa ngokukhawuleza inkqubo yokuphiliswa komzimba, inkqubo yokukhupha emzimbeni, ukubeka iimeko ezintlanu zangaphakathi, ibhalansi, ukulungisa amalungu abonakalayo, isalforaphane inefuthe lokuthintela nonyango lwe-gout.

-Sulforaphane inokusetyenziselwa ukulwa nomhlaza. I-Sulforaphane inokuthintela ngokufanelekileyo isilonda esisesiswini, kwi-atrophic gastritis eguqula umhlaza wesisu

-Sulforaphane isetyenziswa kwintsimi yokutya, i-sulforaphane luhlobo lokutya olufanelekileyo lokuhlaza ukunciphisa umzimba;

-Sulforaphane isetyenziswa kwintsimi yemveliso yezempilo, isilimo esidliwayo esine-celery sinokuzinza imo yemo kunye nokucima uburharha;

-Sulforaphane isetyenziswa kwicandelo lamayeza, ukunyanga i-rheumatism kunye ne-gout inefuthe elihle.

Kaninzi Research

ISulfrafa umgubo ngaphakathi Cancer Cancer uphando

I-Sulforaphane (ngohlobo lokukhutshelwa kwe-broccoli) inika ubungqina bezonyango obunamandla bokuba nendima yokuthintela umhlaza wesibindi kunye neendlela zokuphatha ukuthintela ukuphindaphinda komhlaza wesibindi.

Kwizifundo ezininzi zeklinikhi, amadoda anomhlaza wamanqatha we-prostate othathe i-60 mg ye-sulforaphane ngemini ayenobuncinci be-antigen (PSA, uphawu olwalusetyenziselwa ukulinganisa ukuqhubeka komhlaza we-Prostate) kunalabo abangazange bathathe i-sulforaphane.

Oko bekutshiwo, i-FDA ayivume i-sulforaphane yokuthintela ukuphindaphinda komhlaza wesibindi.

isingqiniso:

  • I-Diulary Sulforaphane kwiCancer Chemoprevention: Indima ye-Epigenetic Regulation kunye ne-HDAC Inhibition Stephanie M. Tortorella, uSimon G. Royce, uPaul V. Licciardi, uTom C. Karagiannis Antioxid Redox Signal. I-2015 Jun 1; 22 (16): 1382-1424. I-Doi: 10.1089 / ars.2014.6097 I-Sulforaphane ilawula i-apoptosis- kunye neendlela ezandayo ezinxulumene nokusayina kunye ne-synergize ene-chisplatin yokucinezela umdlavuza wabantu o-ovarian Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. Ngo-2018 i-Nov; 42 (5): 2447–2458. Ipapashwe kwi-Intanethi ye-2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • I-Bioavailability yeGlucoraphanin kunye neSulforaphane evela ePhakamileyo ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, uMaria H. Traka, uHenri Tapp, uJack R. Dainty, uRichard F. Mithen Mol Nutr Res Res. I-2018 Sep; 62 (18): 1700911. Ipapashwe kwi-intanethi ye-Intanethi 2018 Mar 8. doi: 10.1002 / mnfr.201700911
  • Ukuthintela umhlaza womlomo obangelwa yiCarcinogen-Inceda i-Oral Cancer ngu-Sulforaphane Julie E. Bauman, uYan Zang, uManabika Sen, u-Changyou Li, uLin Wang, uPatricia A. Egner, uJed W. Fahey, UDaniel P. Normolle, uJennifer R. Grandis, uThomas W. Kensler , UDaniel E. Johnson Cancer Prev Res (Phila) Umbhalo obhaliweyo; ifumaneka kwi-PMC 2017 Jul 1. Ipapashwe ngohlobo lokugqibela lokuhlelwa njengo: Cancer Prev Res (Phila). Ngo-2016 uJul; 9 (7): 547-557. Ipapashwe kwi-Intanethi ye-2016 ngoJun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Isifundo sesi-II sesifundo esine-sulforaphane esisityebi se-broccoli siphuma kumadoda anomdlavuza wamandulo u-Joshi J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis UR. Koop, u-Angela Gibbs, uLina Gao, uJason F. Flamiatos, u-Erin Tucker, uRichard Kleinschmidt, uMotomi Mori utyala iziyobisi ezitsha. Umbhalo obhaliweyo; ifumaneka kwi-PMC 2016 Aprili 1. Ipapashwe ngohlobo lokugqibela oluhleliweyo: Tyala amayeza amatsha. Ngo-2015 Aprili; 33 (2): 480-489. Ipapashwe kwi-intanethi ngo-2014 ngo-Novemba ngo-Novemba 29. doi: 10.1007 / s10637-014-0189-z

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.


yokuzonwabisa

Sulforaphane (4478-93-7) ividiyo

IAAA

Iziqulatho kunye nokuqulunqwa kwemveliso

isingqiniso:

  • I-Diulary Sulforaphane kwiCancer Chemoprevention: Indima ye-Epigenetic Regulation kunye ne-HDAC Inhibition Stephanie M. Tortorella, uSimon G. Royce, uPaul V. Licciardi, uTom C. Karagiannis Antioxid Redox Signal. I-2015 Jun 1; 22 (16): 1382-1424. I-Doi: 10.1089 / ars.2014.6097 I-Sulforaphane ilawula i-apoptosis- kunye neendlela ezandayo ezinxulumene nokusayina kunye ne-synergize ene-chisplatin yokucinezela umdlavuza wabantu o-ovarian Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. Ngo-2018 i-Nov; 42 (5): 2447–2458. Ipapashwe kwi-Intanethi ye-2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • I-Bioavailability yeGlucoraphanin kunye neSulforaphane evela ePhakamileyo ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, uMaria H. Traka, uHenri Tapp, uJack R. Dainty, uRichard F. Mithen Mol Nutr Res Res. I-2018 Sep; 62 (18): 1700911. Ipapashwe kwi-intanethi ye-Intanethi 2018 Mar 8. doi: 10.1002 / mnfr.201700911
  • Ukuthintela umhlaza womlomo obangelwa yiCarcinogen-Inceda i-Oral Cancer ngu-Sulforaphane Julie E. Bauman, uYan Zang, uManabika Sen, u-Changyou Li, uLin Wang, uPatricia A. Egner, uJed W. Fahey, UDaniel P. Normolle, uJennifer R. Grandis, uThomas W. Kensler , UDaniel E. Johnson Cancer Prev Res (Phila) Umbhalo obhaliweyo; ifumaneka kwi-PMC 2017 Jul 1. Ipapashwe ngohlobo lokugqibela lokuhlelwa njengo: Cancer Prev Res (Phila). Ngo-2016 uJul; 9 (7): 547-557. Ipapashwe kwi-Intanethi ye-2016 ngoJun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Isifundo sesi-II sesifundo esine-sulforaphane esisityebi se-broccoli siphuma kumadoda anomdlavuza wamandulo u-Joshi J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis UR. Koop, u-Angela Gibbs, uLina Gao, uJason F. Flamiatos, u-Erin Tucker, uRichard Kleinschmidt, uMotomi Mori utyala iziyobisi ezitsha. Umbhalo obhaliweyo; ifumaneka kwi-PMC 2016 Aprili 1. Ipapashwe ngohlobo lokugqibela oluhleliweyo: Tyala amayeza amatsha. Ngo-2015 Aprili; 33 (2): 480-489. Ipapashwe kwi-intanethi ngo-2014 ngo-Novemba ngo-Novemba 29. doi: 10.1007 / s10637-014-0189-z

I-Shangke Chemical yinkampani ephakamileyo yezobuchwepheshe echanekileyo kuma-intermediate asebenzayo (APIs). Ukulawula umgangatho ngexesha lokuvelisa, inani elikhulu labaqeqeshi abanolwazi, izixhobo zokuvelisa iikholeji zokuqala kunye nama-laboratories ngamanqaku aphambili.

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