I-Nicotinamide adenine dinucleotide (53-84-9)

Matshi 15, 2020

INicotinamide adenine dinucleotide (NAD) sisixhobo sokunceda esidibanisa imetabolism efumaneka kuzo zonke iiseli eziphilayo. Ikho ngeendlela ezimbini …….

 


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

 

Ividiyo yeNicotinamide adenine dinucleotide (53-84-9) ividiyo

I-Nikotinamide adenine dinucleotide (53-84-9) Suqobo

Igama lemveliso INicotinamide adenine dinucleotide (NAD +)
Igama leKhemikhali I-Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Inani leCAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
I-Molecular Formula C21H27N7O14P2
Isisindo somzimba 663.4 g / mol
IMasaisotopic Mass 663.109123 g / mol
Indawo yokunyibilika I-160 ° C (320 ° F; 433 K)
umbala Mhlophe
Sitempile yetanki 2-8 ° C
Umzimba I-H2O: 50 mg / mL
isicelo Ukutya kwezempilo, zokuthambisa, ukongeza okondlayo

 

Yintoni i INicotinamide adenine dinucleotide(NAD +)?

I-Nicotinamide adenine dinucleotide (NAD) yi-cofactor enceda imetabolism efumaneka kuzo zonke iiseli eziphilayo. Ifumaneka ngeendlela ezimbini, i-oxidised (NAD +) kunye ne-NADH).

I-Coenzyme NAD +, uhlobo lwe-oxide ye-NAD, yafunyanwa okokuqala ngo-1906 ngabaphengululi basebhritane uArthur Harden noWilliam John Young. I-NAD + yenziwa ngeendlela ezimbini ze-metabolic, ezinokuveliswa kwindlela ye-novo amino acid, okanye enokuveliswa ngezinto ezihlaziyiweyo zangaphambili (ezinjenge-nicotinamide) ukubuyela kwindlela yokuhlangula yeNAD +. Yinto ebalulekileyo ye-pyridine nucleotide kwaye isebenza njenge-cofactor eyimfuneko kunye ne-substrate yeenkqubo ezininzi zeselula ezibandakanya i-phosphorylation ye-oxidative kunye nokuveliswa kwe-ATP, ukulungiswa kwe-DNA, ukumiselwa kwe-epigenetic yokubonisa isini, ukubonakaliswa kwe-calcium ye-intracellular calcium kunye nomsebenzi we-Immunological.

I-NAD + yeyona molekyuli iphambili yokwamkela i-oxidation. Yamkela ii-elektroni kwezinye iimolekyuli kwaye zincitshisiwe. Isebenza njenge-coenzyme ye-hydride transferase kunye ne-substrate esebenzisa iNAD (+) polymerase, kwaye yenza i-coenzyme redox pair nge-β-nicotinamide adenine dinucleotide (NADH). I-NAD (R) yiyunithi ye-ADP-ribose donors unit ribosylation kwi-ADP-A. Ikwangumbanduko we-cyclic ADP-ribose (i-ADP-ribosyl cyclase).

Njenge-oxidant kwi-cell metabolism, i-NAD (R) ikwadlala indima kwi-adenosine diphosphate (ADP) -isusa ukudluliselwa kweempendulo kubandakanya i-diadenylate (ADP-ribose) polymerase kunye nezinye iinkqubo ze-enzymatic. Inokuthintela i-NAD ukuthintela okanye ukunciphisa isifo seswekile, umhlaza kunye nezinye izifo ezinxulumene nobudala. Kwakhona, i-NAD + yokukhuthaza inokusebenza ngokudibeneyo kunye nezongezo ezinje nge-resveratrol ukunceda ukuvuselela i-mitochondria kunye nokulwa nezifo eziguga.

 

INicotinamide adenine dinucleotide(NAD +) izibonelelo

Njengomntu oxididi osebenzayo, iNicotinamide adenine dinucleotide ibonisa ukuba ezinye izibonelelo ezilungileyo kwimisebenzi yabantu.

Lungiselela umsebenzi wakho weselula,

Yandisa amandla akho ngokwendalo;

Ukuphucula ukusebenza kwengqondo, ukugxila kwimemori;

♦ Yandisa imetabolism yakho;

Ukuphucula ukulala;

♦ Ukunyusa umsebenzi we-sirtuin jikelele;

Ukuphucula ukusebenza kwe-antioxidant;

Nciphisa ukudumba;

Ukuphucula ulungelelwaniso, imo, umbono nokuva;

I-Nicotinamide adenine dinucleotid ikwajolise ngqo kwichiza i-isoniazid, esetyenziselwa unyango lwesifo sephepha, isifo esibangelwa yi-Mycobacterium tuberculosis. Kwilingo elinye, iimpuku ezinikwe i-NAD kwiveki enye ziphucule unxibelelwano lwenyukliya-mitochrondrial.

Ukongeza, iNicotinamide adenine dinucleotide (NAD +) nayo inokhuselo kunye nonyango lwebhlothi yentliziyo, ukusebenza kwe-sinus node kunye nokulwa okukhawulezayo kovavanyo lwe-arrhythmias, i-nicotinamide inokuphucula kakhulu izinga lokubetha kwentliziyo kunye ne-atriove ntricular block ebangelwa yi-verapamil.

 

INicotinamide adenine dinucleotide(NAD +) isicelo:

  1. Diagnostic reagents izinto ezingalunganga, iimvavanyo zophando zesayensi.
  2. Ukutya kwezempilo, zokuthambisa, ukongeza okondlayo
  3. Imveliso ye-API

 

Kaninzi INicotinamide adenine dinucleotide(NAD +) uphando

Ii-enzymes ezenza kwaye zisebenzise i-NAD + kunye ne-NADH zibalulekile kwi-pharmacology nakuphando kunyango lwexesha elizayo lwezifo. I-coenzyme NAD + ayisetyenziswanga njengonyango lwaso nasiphi na isifo. Nangona kunjalo, kuyafundwa ukuba isetyenziswe njani kunyango lwezifo ze-neurodeergenerative ezinje ngesifo se-Alzheimer's kunye neParkinson.

 

Imbekiselo:

  • UBhelenky P, uBogan KL, uBrenner C (2007). "I-NAD + imetabolism kwimpilo nakwizifo" (PDF). Iindlela eziHambelanayo. Inzululwazi. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Kugciniwe kwi-PDF yoqobo (PDF) nge-4 Julayi 2009. Ibuyisiwe nge-23 Disemba 2007.
  • UTodisco S, uAgrimi G, uCastegna A, uPalmieri F (2006). "Ukuchongwa kwe-mitochondrial NAD + yokuhambisa kwi-Saccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. IINKCUKACHA:
  • ILin SJ, uGuarente L (Epreli 2003). "I-Nicotinamide adenine dinucleotide, umlawuli we-metabolic wokukhutshelwa, ubomi obude kunye nezifo". Ikhonkco. Opin. Iseli yeBiol. I-15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. IINKCUKACHA:
  • UWillionon DH, uLund P, uKrebs HA (1967). "Imeko redox yasimahla ye-nicotinamide-adenine dinucleotide kwi cytoplasm kunye ne mitochondria yesibindi sebuzi". Indalo. J. 103 (2): 514– doi: 10.1042 / bj1030514. I-PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Matshi 1980). "INicotinamide adenine dinucleotide biosynthesis kunye ne-pyridine nucleotide cycle metabolism in microbial systems". Microbiol. ISityhi 44 (1): 83– PMC 373235. PMID 6997723.
  • IsiFrentshi SW. Ukusela utywala ngokungapheliyo kwenzakalisa isibindi kunye namanye amalungu ngokunciphisa amanqanaba e-NAD⁺ afunekayo kwimisebenzi ye-sirtuin deacetylase. Exp Mol Pathol. Ngo-2016 kuMatshi; 100 (2): 303-6. ikhonkco: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. I-Sirtuins kunye ne-NAD + kuPhuculo kunye nonyango lweZifo zeMetabolic kunye neZifo zeNtliziyo. Isangqa Res. I-2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. I-PMID: 30355082. PMCID: PMC6206880.