I-Nicotinamide adenine dinucleotide (53-84-9)

Matshi 15, 2020
SKU: 53-84-9
5.00 ngaphandle kwe 5 ngenxa ye 1 ireyithingi abathengi

I-Nicotinamide adenine dinucleotide (NAD) yi-cofactor enceda imetabolism efumaneka kuzo zonke iiseli eziphilayo. Ifumaneka ngeendlela ezimbini ………………….


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum

Ividiyo yeNicotinamide adenine dinucleotide (53-84-9) ividiyo

I-Nikotinamide adenine dinucleotide (53-84-9) Suqobo

Igama lemveliso INicotinamide adenine dinucleotide (NAD +)
Igama leKhemikhali I-Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Inani leCAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
I-Molecular Formula C21H27N7O14P2
Isisindo somzimba 663.4 g / mol
IMasaisotopic Mass 663.109123 g / mol
Indawo yokunyibilika I-160 ° C (320 ° F; 433 K)
umbala Mhlophe
Sitempile yetanki 2-8 ° C
Umzimba I-H2O: 50 mg / mL
isicelo Ukutya kwezempilo, zokuthambisa, ukongeza okondlayo

Yintoni i INicotinamide adenine dinucleotide(NAD +)?

I-Nicotinamide adenine dinucleotide (NAD) yi-cofactor enceda imetabolism efumaneka kuzo zonke iiseli eziphilayo. Ifumaneka ngeendlela ezimbini, i-oxidised (NAD +) kunye ne-NADH).

I-Coenzyme NAD +, uhlobo lwe-oxide ye-NAD, yafunyanwa okokuqala ngo-1906 ngabaphengululi basebhritane uArthur Harden noWilliam John Young. I-NAD + yenziwa ngeendlela ezimbini ze-metabolic, ezinokuveliswa kwindlela ye-novo amino acid, okanye enokuveliswa ngezinto ezihlaziyiweyo zangaphambili (ezinjenge-nicotinamide) ukubuyela kwindlela yokuhlangula yeNAD +. Yinto ebalulekileyo ye-pyridine nucleotide kwaye isebenza njenge-cofactor eyimfuneko kunye ne-substrate yeenkqubo ezininzi zeselula ezibandakanya i-phosphorylation ye-oxidative kunye nokuveliswa kwe-ATP, ukulungiswa kwe-DNA, ukumiselwa kwe-epigenetic yokubonisa isini, ukubonakaliswa kwe-calcium ye-intracellular calcium kunye nomsebenzi we-Immunological.

I-NAD + yeyona molekyuli iphambili yokwamkela i-oxidation. Yamkela ii-elektroni kwezinye iimolekyuli kwaye zincitshisiwe. Isebenza njenge-coenzyme ye-hydride transferase kunye ne-substrate esebenzisa iNAD (+) polymerase, kwaye yenza i-coenzyme redox pair nge-β-nicotinamide adenine dinucleotide (NADH). I-NAD (R) yiyunithi ye-ADP-ribose donors unit ribosylation kwi-ADP-A. Ikwangumbanduko we-cyclic ADP-ribose (i-ADP-ribosyl cyclase).

Njengomntu oxidant kwi-metabolism yeseli, i-NAD (R) ikwadlala indima kwi-adenosine diphosphate (ADP) -kuhambisa ukuguqula iziphumo ezibandakanya i-diadenylate (ADP-ribose) polymerase kunye nezinye iinkqubo ezahlukeneyo ze-enzymatic. Inganikeza ngokungqalileyo i-NAD ukunqanda okanye ukunciphisa isifo seswekile, umhlaza kunye nezinye izifo ezinxulumene nobudala. Kwakhona, ii-boader ze-NAD + zinokusebenza ngokubambisana kunye nezongezelelo ezifana ne-resveratrol yokunceda ukuphinda i-mitochondria kwaye ilwe nezifo zokuguga.

INicotinamide adenine dinucleotide(NAD +) izibonelelo

Njengomntu oxididi osebenzayo, iNicotinamide adenine dinucleotide ibonisa ukuba ezinye izibonelelo ezilungileyo kwimisebenzi yabantu.

♦ Yenza umsebenzi wakho weselula,

Ukonyusa amandla akho ngokwemvelo;

♦ Ukuphucula ukusebenza kwengqondo, ukujonga kunye nememori;

♦Khulisa imetabolism yakho;

Phucula ukulala;

Ukunyusa umsebenzi we-Sirtuin yehlabathi;

♦ Ukuphucula ukusebenza kwe-antioxidant;

♦ Ukunciphisa ukuvuvukala;

Balance Ukuphuculwa komgangatho wokulinganisa, imvakalelo, umbono kunye nokuva;

I-Nicotinamide adenine dinucleotid ikwajolise ngqo kwichiza li-isoniazid, elisetyenziswa kunyango lwesifo sephepha, usulelo olubangelwa sisifo sephepha iMycobacterium. Kwilingo elinye, iimpuku ezinikezwe i-NAD ngeveki enye ziphucule unxibelelwano lwenyukliya-mitochrondrial.

Ukongeza, iNicotinamide adenine dinucleotide (NAD +) nayo inokhuselo kunye nonyango lwebhlothi yentliziyo, ukusebenza kwe-sinus node kunye nokulwa okukhawulezayo kovavanyo lwe-arrhythmias, i-nicotinamide inokuphucula kakhulu izinga lokubetha kwentliziyo kunye ne-atriove ntricular block ebangelwa yi-verapamil.

INicotinamide adenine dinucleotide(NAD +) isicelo:

  1. Diagnostic reagents izinto ezingalunganga, iimvavanyo zophando zesayensi.
  2. Ukutya kwezempilo, zokuthambisa, ukongeza okondlayo
  3. Imveliso ye-API

Kaninzi INicotinamide adenine dinucleotide(NAD +) uphando

Ii-enzymes ezenza kwaye zisebenzise i-NAD + kunye ne-NADH zibalulekile kwi-pharmacology kunye nophando kunyango lwexesha elizayo lwesifo. I-coenzyme NAD + ayisiyisebenzisi njengangoku njengonyango. Nangona kunjalo, ifundwa ngokusetyenziswa kwayo okunokwenzeka kunyango lwezifo ze-neurodegenerative ezifana nesifo iAlzheimer's andParkinson.

Imbekiselo:

  • IBelenky P, iBogan KL, iBrenner C (2007). "I-NAD + imetabolism kwimpilo kunye nezifo" (PDF). Iindlela zebhayiloji. Inzululwazi. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. I-PMID 17161604. Igcinwe kwiphepha lokuqala (le-PDF) nge-4 kaJulayi ka-2009. Ibuyisiwe ngomhla wama-23 kuDisemba ngo-2007.
  • I-Todisco S, iAgrimi G, iCastegna A, iPalmieri F (2006). Ukuchongwa kwe-mitochondrial NAD + transporter kwi-Saccharomyces cerevisiae ". J. Biol. Imichiza. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • I-Lin SJ, iGuarente L (ngo-Epreli 2003). "I-Nicotinamide adenine dinucleotide, isilawuli se-metabolic sokukhutshelwa, ubomi obude kunye nezifo". Ikratshi. Opin. Iseli Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Imeko ye-redox yenicotinamide-adenine dinucleotide yasimahla kwi-cytoplasm kunye ne-mitochondria yesibindi". Ibhayoloji. J. 103 (2): 514- doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Ukuxhasa iJW, Moat AG (1 Matshi 1980). "I-Nicotinamide adenine dinucleotide biosynthesis kunye ne-pyridine nucleotide umjikelo we-metabolism kwiinkqubo ze-microbial". I-Microbiol. ISityhi 44 (1): 83– PMC 373235. PMID 6997723.
  • I-French SW. Ukulawulwa kotywala okungalunganga kulimaza isibindi kunye namanye amalungu ngokunciphisa amanqanaba e-NAD⁺ ayimfuneko kwimisebenzi ye-sirtuin deacetylase. Utsho uMol Pathol. Ngo-2016 u-Aprili; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. I-Sirtuins kunye ne-NAD + kuPhuculo kunye nonyango lweZifo zeMetabolic kunye neZifo zeNtliziyo. Isangqa Res. I-2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. I-PMID: 30355082. PMCID: PMC6206880.

ISIQINISEKISO NESIBONELELO:

Le nto ithengiselwe uKwenziwa koPhando kuphela. Imigaqo yokuthengisa Faka isicelo. Ayisetyenziselwa uBuntu, okanye oNyango, iZilwanyana, okanye abaNtu.