Cannabidiol (CBD)

Juni 21, 2021

I-Cannabidiol (i-Cannabidiol, i-CBD) yenye yezinto ezingaphezu kwekhulu ezisebenzayo ze-cannabis enexabiso lezonyango. Ihlaziya umzimba nengqondo, ikhusele imithambo-luvo, iphucule ukuvuvukala kolusu, ii-antioxidants, isuse ububomvu kulusu, kwaye yakhe isithintelo esikhuselayo kumphezulu wolusu. Ukuphucula amandla okuzilungisa kwesikhumba; ukubuyisela impilo yolusu kunye nokunciphisa iingxaki zolusu, inokunyanga i-eczema kunye nezinye izifo.

I-Cannabidiol (i-CBD) lelona candelo liphambili lokungabinangqondo le-cannabis kwaye lineziphumo ezahlukeneyo ze-pharmacological, kubandakanya ne-anti-ixhala, i-anti-psychotic, antiemetic kunye nepropathi yokuthintela ukudumba.

Ulwazi ngemichiza yeCannabidiol (CBD)

Igama lemveliso I-Cannabidiol powder
Iintetho ezifanayo (-) - ICannabidiol

(-) - iTrans-Cannabidiol

Epidiolex

CBD

Ukungcola 99% Khetha / ukongeza amanye amaCandelo (CBD≥99.5%)
Inani leCAS 13956-29-1
Iqela leziyobisi ICannabinoid
InChI isitshixo I-QHMBSVQNZZTUGM-ZWKOTPCHSA-N
SMILE CCCCCC1 = CC (= C (C (= C1) O) C2C = C (CCC2C (= C) C) C) O
I-Molecular Formula C21H30O2
Isisindo somzimba 314.5 g / mol
IMasaisotopic Mass 314.224580195
Indawo yokunyibilika 66 ° C
Point yo kubilisa 160 ° C - 180 ° C
Eukunciphisa ubomi besiqingatha Iiyure ze-18-32
umbala Mhlophe ukuya kumthubi okhanyayo we-crystalline powder
Umzimba I-Soluble kwi-oyile, inyibilika kakhulu kwi-ethanol kunye ne-methanol, ayinyibiliki emanzini
Sitempile yetanki Iqondo lobushushu kwigumbi, hlala umile kwaye kude nokukhanya
isicelo Ngeenjongo zophando lwezenzululwazi kuphela, okanye njengezinto ezingafunekiyo zophuhliso lweemveliso ezisezantsi, okanye ukuthengiswa kumazwe asemthethweni nakwimimandla engaphandle. Nceda uqaphele ukuba ezi mveliso akufuneki zisetyenziswe ngokuthe ngqo okanye zisetyenziselwe unyango lweklinikhi kwilizwe lase China
Izibonelelo zethu eziPhambili l 100% ukukhutshwa kwendalo, imveliso yesikali seshishini, unikezelo oluzinzileyo

l Uqinisekiso lomgangatho (GMPC, ISO22716, KOSHER, HALAL)

l Ilebhu yomntu wesithathu kuvavanywa, kuzinzile kwaye kuphezulu umxholo we-CBD, i-THC yasimahla

l Indlela HPLC. Izinyithi ezinzima, iintsalela kunye ne-microbial zidibana nemigangatho ye-CHP, JP kunye ne-USP

 

Yintoni iCannabidiol (CBD)? Inkcazo yeCannabidiol

I-Cannabidiol yikhemikhali kwisityalo se-Cannabis sativa, esaziwa nangokuthi yi-marijuana okanye i-hemp. Ngaphezulu kweekhemikhali ezingama-80, ezaziwa ngokuba zii-cannabinoids, zichongiwe kwisityalo seCannabis sativa. Ngelixa i-delta-9-tetrahydrocannabinol (THC) sesona sithako siphambili sentsangu, i-cannabidiol ikwafumaneka kwi-hemp, enexabiso elincinci kakhulu le-THC. Zombini i-hemp kunye nentsangu luhlobo lweCannabis sativa, kodwa ngokwahluka okwahlukileyo.

  • I-Marijuana ikhula ngeepesenti eziphezulu ze-THC (psychoactive; ibangela imvakalelo "ephezulu"), kunye neepesenti ezisezantsi ze-CBD (enganxilisiyo).
  • I-hemp ikhula ngeepesenti eziphezulu zeCannabidiol (CBD), kunye neepesenti ezisezantsi ze-THC.

Nangona i-THC ngokulula iyinto edume kakhulu kwi-cannabinoid ngenxa yeempembelelo zayo zengqondo, i-Cannabidiol (i-CBD) ifumene i-traction ngenxa yokunganxilisi [2], izibonelelo zonyango. NgokukaMbutho wezeMpilo weHlabathi, i-CBD ayisiyomlutha, ayinazimpawu zokurhoxa, kwaye ineprofayili enkulu yokhuseleko, yiyo loo nto ingamangalisi into yokuba uninzi luphethukela kwiCannabidiol (CBD) yomgubo ngezibonelelo zalo ezininzi zonyango. Eyona nto ibaluleke kakhulu, umgubo we-CBD unokunceda ekunciphiseni uxinzelelo [1], iimeko zokuvuvukala, kunye nentlungu engapheliyo.

I-Phcoker i-cannabidiol powder, i-100% ikhutshwe ngokwemvelo kwi-hemp yoshishino, i-THC ikhululekile.

I-Cannabidiol ixhaphake kakhulu kwisifo sokuxhuzula (isifo sokuwa). Isetyenziselwa uxinzelelo [1], iintlungu, ukuphazamiseka kwezihlunu okubizwa ngokuba yi-dystonia, isifo se-Parkinson, isifo se-Crohn, kunye nezinye iimeko ezininzi, kodwa abukho ubungqina obuchanekileyo benzululwazi obuxhasa ezi zinto zisetyenziswayo.

 

Cannabidiol (CBD) kunye Ulwalamano lwe-THC

I-CBD inolwalamano oluntsonkothileyo kunye ne-cannabinoid delta-9-tetrahydrocannabinol (THC), eyona nto iphambili kwi-cannabis, kwaye inoxanduva lokuchaphazela intsangu okanye i-hashish.

Ngokungafaniyo ne-THC, i-CBD ayisebenzi ngokuthe ngqo ngengqondo yokuba ayibonisi uvuyo okanye 'phezulu'. Oku akufani nokuthi i-CBD ayisebenzi ngokupheleleyo. Kwindawo yokuqala, kukho ubungqina obuninzi bokuthi i-CBD imodareyitha iziphumo ze-THC. [8] [10]

Okwesibini, bambalwa abantu (malunga neepesenti ezi-5) abanika ingxelo yokutshintsha kwemiphumela ye-CBD, ngendlela efanayo ukuba ezinye izigulana zinokuba neziphumo zengqondo ezivela eTylenol okanye eAdvil. Nangona kunjalo, kukholelwa ukuba uninzi lweengxelo lubangelwa kukutya i-CBD equlathe umkhondo we-THC. Kungoko ukubaluleka kokufumana i-Cannabidiol kwimithombo ekumgangatho ophezulu.

 

Isebenza njani iCannabidiol? Indlela yokusebenza ye-CBD

I-CBD kunye ne-THC bayasebenzisana nemizimba yethu ngeendlela ezahlukeneyo. Enye yeendlela eziphambili kukulinganisa kunye nokwandisa iimpembelelo zemixube emizimbeni yethu ebizwa ngokuba yi "endo native cannabinoids" - ebizwa njalo ngenxa yokufana kwabo kwimixube efumaneka kwisityalo se-cannabis.

I-Cannabidiol powder ineempembelelo kwingqondo. Oyena nobangela wale miphumela akucaci. Nangona kunjalo, i-cannabidiol ibonakala ikuthintela ukonakala kwemichiza kwingqondo echaphazela iintlungu, imo yokusebenza kunye nokusebenza kwengqondo. Ukuthintela ukonakala kwale khemikhali kunye nokwandisa amanqanaba ayo egazini kubonakala kunciphisa iimpawu zengqondo ezinxulumene neemeko ezinje ngesifo sengqondo. I-Cannabidiol (i-CBD) inokuthintela ezinye zeziphumo zengqondo ze-delta-9-tetrahydrocannabinol (THC). Kwakhona, i-cannabidiol ibonakala inciphisa iintlungu noxinzelelo [1].

 

I-CBD kunye ne-Endocannabinoid System (ECS)

I-ECS yafunyanwa kwii-1990s kwaye kucingelwa ukuba yenye yezona nkqubo zibalulekileyo nezikhulu zokufumana impilo esempilweni kwaye yamkelwe njengenkqubo ebalulekileyo yemodyuli ekusebenzeni kwengqondo, i-endocrine kunye nezicubu zomzimba.

Inzululwazi yamva nje ifumanise ukuba i-ECS ayiphenduli kuphela kwii-cannabinoids ezingapheliyo eziveliswe emzimbeni kodwa iyaphendula nakwiPhytocannabinoids yangaphandle okanye i-CBD njengendlela yokuphucula imizimba ye-ECS. [7]

Ngaphakathi kwi-ECS kukho ii-receptors CB1 kunye ne-CB2, ezifumaneka emzimbeni wonke. Ezi neurons luhlobo lokukhiya, kunye ne-cannabinoids esebenza njengeyona nto iphambili. Ii-receptors ze-CB1 zikhona kumanani aphezulu kwingqondo, ngakumbi kwiHypothalamus, Hippocampus kunye neAmygdala. Ii-receptors ze-CB2 zenzeka ngokuxhaphakileyo kudakada, iitoni, i-thymus kunye neeseli zomzimba. Inkqubo ye-endocannabinoid idlala indima yokungenisa kwi-homeostasis.

I-CBD ayisebenzisani ngokuthe ngqo kunye ne-cannabinoid receptors (CB1 kunye ne-CB2) [9], kodwa endaweni yoko, ivuselela inkqubo ye-endocannabinoid ukuvelisa ii-cannabinoids zayo. Ukongeza, kunciphisa ukonakala kwabo ngokuthintela i-FAAH enzyme, ke ii-endocannabinoids zihlala emzimbeni wakho ixesha elide. I-CBD yinto enobunzima be-cannabinoid kunye nokunxibelelana kwayo nenkqubo ye-endocannabinoid kufuneka iphandwe nzulu ukuveza amandla ayo apheleleyo.

 

Ngaba i-CBD isemthethweni? Ityhefu ye-Cannabidiol

I-CBD yinxalenye enganxilisiyo yesityalo se-cannabis esinamandla amakhulu okuphilisa [2]. I-Cannabidiol (i-CBD) ifumene ukubambeka ngenxa yokunga nxilisi, izibonelelo zonyango. NgokukaMbutho wezeMpilo weHlabathi, i-CBD ayisiyomlutha, ayinazimpawu zokurhoxa, kwaye ineprofayili enkulu yokhuseleko. Ngelixa uLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) alulawuli ubunyulu okanye ukhuseleko lwento, i-CBD ithathwa njengekhuselekileyo.

Ukuwiswa koMthetho oYilwayo weFama ka-2018 wenze ukuba kuthengiswe iimveliso ze-hemp kunye ne-hemp e-US ngokusemthethweni oko akuthethi ukuba zonke iimveliso ze-hemp-derived cannabidiol zisemthethweni. Kuba i-cannabidiol ifundwe njengechiza elitsha, ayinakubandakanywa ngokusemthethweni kukutya okanye kwizongezo zokutya. Kwakhona, i-cannabidiol ayinakufakwa kwiimveliso ezithengiswa ngamabango onyango. I-Cannabidiol inokufakwa kuphela kwiimveliso "zezithambiso" kwaye kuphela ukuba iqulethe ngaphantsi kwe-0.3% THC. Kodwa kusekho iimveliso ezibhalwe njengezongezo zokutya kwimarike equlathe i-cannabidiol. Inani le-cannabidiol equlethwe kwezi mveliso alisoloko lichazwa ngokuchanekileyo kwileyibhile yemveliso.

 

Izibonelelo zezempilo ze-CBD

Kuvunyiwe ukunyanga isifo sokuwa

Iipropathi ezingezizo ezengqondo ze-CBD ziyenza ilungele ukusetyenziswa kwezonyango. Kwi-2018, ichiza lokuqala elivunyiweyo le-FDA, i-cannabidiol (Epidiolex), equlathe i-CBD yakhutshwa kwintengiso ukunyanga iintlobo ezimbini ezahlukeneyo zesifo sokuwa [3] [4] -I-Dravet syndrome kunye neLennox-Gastaut syndrome.

I-FDA ilwamkele unyango kwizigulana ezineminyaka emibini ubudala. Izifundo zibonise ukuba ziyasebenza xa kuthelekiswa ne-placebo ekunciphiseni ukubanjwa kwexesha.

 

Ukunyanga uxinzelelo[1]

Nangona sifuna uphando oluthe kratya, inqaku lophononongo lonyango lowama-2015 lajonga i-CBD kunye nefuthe layo kwiziphazamiso ezininzi zoxinzelelo, kubandakanya ukuphazamiseka koxinzelelo ngokubanzi, ukuphazamiseka okwenzeka ngamaxesha athile onyaka, ukuphazamiseka kovalo, kunye noxinzelelo lwasemva koxinzelelo.

Iziphumo zibonise ukuba kukho "ubungqina obuqinileyo" bokuxhasa unyango lweengxaki zokuxhalaba kunye ne-CBD, nangona uphando olongezelelweyo lufunekayo kwi-dosing yexesha elide.

 

Unokuyiphelisa Intlungu

Izifundo zibonise ukuba i-CBD inokunceda ukunciphisa iintlungu ezingapheliyo ngokuchaphazela umsebenzi we-endocannabinoid receptor, ukunciphisa ukudumba [6] kunye nokunxibelelana neeurotransmitters. Xa i-CBD ichaphazela i-TRPV1, kuthintela ngokufanelekileyo imiqondiso yeentlungu ekufikeleleni kuwo wonke umzimba. Umxholo ubonelela ngenduduzo kwi-aches, ukudumba kunye nokungonwabi.

 

Ngaba unokunciphisa amaBala

Amabala yimeko eqhelekileyo yolusu echaphazela ngaphezulu kwe-9% yabemi.

Kucingelwa ukuba kubangelwa zizinto ezininzi, kubandakanya ufuzo, ibhaktiriya, ukuvuvukala okungaphaya kunye nokuveliswa kakhulu kwe-sebum, ukhuseleko olunamafutha olwenziwe ngamadlala asabisayo kulusu.

Ngokusekwe kwizifundo zesayensi zamva nje, ioyile ye-CBD inokunceda ukunyanga induna ngenxa yeempawu zayo ezichasayo [6] kunye nokukwazi ukunciphisa imveliso ye-sebum.

Olunye uphononongo lwe-tube-test lwafumanisa ukuba ioyile ye-CBD ithintele iiseli zelisaceous ze-sebaceous ekufihleleni i-sebum egqithisileyo, ikhupha isenzo sokuchasana nokuthintela ukwenziwa kweearhente ze "pro-acne" ezinjengee cytokines ezivuthayo.

Olunye uphononongo luye lwafumana iziphumo ezifanayo, kugqitywa ukuba i-CBD inokuba yindlela efanelekileyo nekhuselekileyo yokunyanga amabala, enkosi kwinxalenye yeempawu zayo ezichaseneyo nokudumba.

 

Ukusetyenziswa kwepowder yeCannabidiol (CBD) kunye nokusetyenziswa

Uphando lukhawuleze njengoko isakhelo sentlalontle, somthetho kunye nomthetho malunga nokusetyenziswa kwe-cannabis siphantsi kohlengahlengiso kwiindawo ezininzi zehlabathi, ukuvelisa idatha entsha.

Uphando lwezonyango kwi-CBD umgubo lubandakanye izifundo ngoxinzelelo, ukuqonda, ukuphazamiseka kwentshukumo kunye nentlungu.

I-CBD powder ingathathwa emzimbeni ngeendlela ezininzi, kubandakanywa nokuphefumula umsi okanye umphunga, njenge-spray aerosol esidleleni, nangomlomo. Inokukhutshwa njengeoyile ye-CBD okanye njengesisombululo esimiselweyo.

Kuyo yonke i-US, abantu bathambisa i-CBD balm kumalungu aqaqambayo, bewisa i-CBD tinctures phantsi kweelwimi ezidiniweyo, ukuphuma kwe-gummies ze-CBD, kunye nokukhukhumala kwi-CBD egcwele ioyile ngeoli yokuphefumla.

 

Iingxelo:

[1] I-Cannabidiol njengonyango olunokubakho lokuphazamiseka koxinzelelo. Iintsikelelo ze-EM, iSteenkamp MM, iManzanares J, iMarmar CR. Neurotherapeutics. 2015 Oktobha; 12 (4): 825-36. ikhonkco: 10.1007 / s13311-015-0387-1.

[2] Iziphumo ezibi zeCannabidiol kunye neTyhefu. IHuestis MA, uSolimini R, uPichini S, uPacifici R, uCarlier J, uBusardò FP. Ikhonkco Neuropharmacol. Ngo-2019; 17 (10): 974-989. ikhonkco: 10.2174 / 1570159X17666190603171901.

[3] Isifo sokuwa kunye ne-cannabidiol: isikhokelo kunyango. Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, iPhaneli yeeNgcali zaMazwe ngaMazwe zeCannabinoids; AbaSebenzi. Isifo sokuwa. NgoFebruwari 2020 Feb 1; 22 (1): 1-14. ikhonkco: 10.1684 / epd.2020.1141.

[4] I-Cannabidiol: Ukuphononongwa ngokuSebenza kweKlinikhi kunye noKhuseleko kwi-Epilepsy. USamanta D.Pediatr Neurol. 2019 Julayi; 96: 24-29. ikhonkco: 10.1016 / j.pediatrneurol.2019.03.014. Epub 2019 Mar 22.

[5] I-Cannabidiol: Ubume bobugcisa kunye nemiceli mngeni emitsha kwizicelo zonyango. IPisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M. Pharmacol Ther. Ngo-2017 uJulayi; 175: 133-150. ikhonkco: 10.1016 / j.pharmthera.2017.02.041. Epub 2017 ngoFebruwari 22.

[6] I-Cannabidiol (i-CBD) kunye ne-analogs yayo: uphononongo lwefuthe labo kukudumba. UBurstein S. Bioorg Med Chem. 2015 kuMatshi 1; 23 (7): 1377-85. ikhonkco: 10.1016 / j.bmc.2015.01.059. Epub 2015 ngoFebruwari 7.

[7] Inkqubo ye-Endocannabinoid kunye neModyuli yayo yeCannabidiol (CBD). ICorroon J, uFelice JF. Enye iTher Health Med. 2019 Juni; 25 (S2): 6-14.

[8] Ukuphononongwa ngokuBalulekileyo kwendima yeCannabinoid Compounds delta (9) -Tetrahydrocannabinol (delta (9) -THC) kunye neCannabidiol (CBD) kunye nokudityaniswa kwabo kunyango lwe-Multiple Sclerosis. UJones É, Vlachou S.Iimolekyuli. Ngo-2020 Oktobha 25; 25 (21): 4930. doi: 10.3390 / iimolekyuli25214930.

[9] I-CB1 eyahlukeneyo kunye ne-CB2 receptor pharmacology yezityalo ezintathu ze-cannabinoids: i-delta9-tetrahydrocannabinol, i-cannabidiol kunye ne-delta9-tetrahydrocannabivarin. IPertwee RG. UBr J Pharmacol. Ngo-2008 uJan; 153 (2): 199-215. ikhonkco: 10.1038 / sj.bjp.0707442. Epub 2007 Sep 10.

[10] Ubungqina beKlinikhi kunye ne-Preclinical yokuNxibelelana okuSebenzayo kweCannabidiol kunye ne-delta (9) -Tetrahydrocannabinol. IiBoggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M. Neuropsychopharmacology. NgoJanuwari 2018; 43 (1): 142-154. ikhonkco: 10.1038 / npp.2017.209. Epub 2017 Sep 6.