I-NMN powder (1094-61-7)

Oktobha 30, 2018

Umzi mveliso wethu uyakwazi ukuvelisa ngaphezulu kwe-1370kg Nicotinamide Mononucleotide (nmn) powder ngenyanga phantsi kweemeko ze-GMP.


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1370kg / inyanga

yokuzonwabisa

 

iinkcukacha

Igama lemveliso I-Nicotinamide Mononucleotide (NMN)
Izithethantonye Igama NAMN, β-NMN, β-Nicotinamide Mononucleotide okanye iBeta Nicotinamide Mononucleotide;

beta-NMN

Iqela leziyobisi Ukutya okuncedisayo
Inani leCAS 1094-61-7
InChIKey I-DAYLJWODMCOQEW-TURQNECASA-N
Ifomula yeMolekyuli C11H15N2O8P
Ubunzima beMolekyuli 334.22 g / mol
IMasaisotopic Mass 334.056602 g / mol
Indawo yokunyibilika  166 ° C (umhla wokugqibela)
Indawo yokuBanda N / A
I-Biological Half-Life N / A
umbala Mhlophe ukuba ngumgubo omhlophe
Umzimba  I-Beta-NMN ibonelelwa njenge-crystalline solid. I-Beta-NMN inqabile inyibilika kwizinyibilikisi ezinjenge-ethanol, i-DMSO, kunye ne-dimethyl formamide. Kuvavanyo lwebhayoloji, sicebisa ukuba izisombululo zamanzi ezingenasinyibilikisi zeBeta-NMN zilungiswe ngokusombulula ngokuthe ngqo isikristali esomeleleyo kwii-buffer ezinamandla. Ubunyibilikisi beBeta-NMN kwi-PBS, pH 7.2, imalunga ne-10 mg / ml. Asikukhuthazi ukugcina isisombululo samanzi ngaphezulu kosuku olunye.
Ubushushu bokugcina  Igumbi le-temperatur;

Gcina e -20 ° C ukuya kuthi ga kwiminyaka emibini.

isicelo Izongezo zokutya eziguga

 

Imbali yeNMN

I-Nicotinamide mononucleotide (ifomula yee molekyuli: C11H15N2O8P, inombolo ye-CAS: 1094-61-7, ekwabizwa ngokuba yi-NMN, i-beta-Nicotinamide mononucleotide okanye i-)-NMN) yi-vitamin B3 metabolite [1], efumaneka ngokwendalo emzimbeni womntu, kwaye ngokufanayo ukutya okufana ne-broccoli kunye neklabishi ngesixa esincinci [2].

I-NMN yaqala ukufumana inzala njengoncedo lokutya olunokubakho kwi-2013, emva kophando olwenziwe ngoososayensi baseHarvard kwiimpuku [3,4].

I-NMN yaqala ukuveliswa njengesongezelelo sabantu ngo-2015 [5], kodwa yayibiza kakhulu ukuvelisa, de kwaphuhliswa iindlela zokunciphisa iindleko zemveliso kunye nokonyusa ubunyulu ngo-2018 [6], ngeloxesha iilebhu zenzelwe imveliso ngobuninzi zaqala yiza kwi-intanethi.

 

Yintoni ipowder yeNMN?

I-Nicotinamide mononucleotide (ifomula yee molekyuli: C11H15N2O8P, inombolo ye-CAS: 1094-61-7, ekwabizwa ngokuba yi-NMN, i-beta-Nicotinamide mononucleotide okanye i-)-NMN) yi-vitamin B3 metabolite [1], efumaneka ngokwendalo emzimbeni womntu, kwaye ngokufanayo ukutya okufana ne-broccoli kunye neklabishi ngesixa esincinci [2].

I-Nicotinamide Mononucleotide (i-NMN) yinto eyenzeka ngokwendalo ekwisixa esincinci emzimbeni womntu nakukutya okuthile. I-NMN ayifumaneki ngomlomo, kwaye xa ithathwa ngomlomo inokuxhasa amanqanaba e-NAD + ngaphakathi kwesibindi kunye nezicubu zomzimba.

Uphando lwamva nje lucebise ukuba i-NMN inokuxhasa impilo yentliziyo, imveliso yamandla, impilo yokuqonda, kunye ne-retinal kunye nethambo. Enye into enomdla ngakumbi kuphando lwe-NMN kukuba inokukhuthaza ukulungiswa kwe-DNA kunye nokuxhasa ukwenziwa kohlobo lwe-SIRTUIN ekucingelwa ukuba ludlala indima ekugugeni okusempilweni.

 

Isebenza njani?

I-NMN sisandulela semolekyuli ye-NAD +; umzimba womntu ufuna i-NMN ukuze yenze i-NAD + yayo.

I-NAD + yindlela ye-NAD (Nicotinamide adenine dinucleotide), imolekyuli eyaqala ukufunyanwa ngo-1906, yafunyanwa kuzo zonke iiseli eziphilayo [7].

Ukuxhaswa nge-NAD + ngokwayo akuyona inketho yokunyusa amanqanaba e-NAD, kuba inkulu kakhulu ukuwela ngokukhawuleza iimbumba zeeseli ukungena kwiiseli, ngoko ke akunakukwazi ukuchaphazela ngokuqinisekileyo imetabolism [8].

 

Izibonelelo zeNMN.

Enye indlela esinokugcina ngayo amanqanaba empilo e-NAD + kukuxhasa imizimba yethu ngengandulelo yayo, Inicotinamide mononucleotide (NMN).

Uphando lwangoku lubonisa ukuba olu tshintsho phakathi kwe-NR kunye ne-NMN kufuneka lwenziwe ukungena kwiindidi ezimbalwa zeeseli. Oku kukhokelela ekubeni abaphandi bakholelwe ukuba i-NMN, enyanisweni, yenye yeendlela ezikhawulezayo zokukhuthaza imveliso ye-NAD. Nangona kunjalo, iNicotinamide mononucleotide powder ikwangqina ukuba inezibonelelo zokulwa ukuguga ezingaphaya kwemveliso yeNAD yodwa.

Ukongeza kwindlela ye-metad ye-NAD, i-NMN powder ingongezwa ngokuthe ngqo kwiiseli ngaphandle kokuguqula i-NAD. Le nto yenzeka ngenxa yeeprotein zothutho ezisandula ukufunyanwa ezonyuka ngenani emva kokuba amanqanaba e-NAD eyekile. Kule fomu, i-NMN inegalelo kumandla eseli kwaye ivumela nganye yeepropathi ezichasene nokuguga ezikhankanywe ngaphambili ezikhuthazwa ziiseli ezinamandla ngokwaneleyo okukhula kunye nokuhlaziya.

Ukukhetha ukongeza kunye ne-NMN powder kunye ne-NAD kubonelela ngendlela ethe kratya ekukhuthazeni imetabolism yeseli kwaye ke yindlela ekhawulezayo yokwenza okufanayo. Ukongeza, iNicotinamide mononucleotide powder ifunyenwe ukuphucula umsebenzi we-insulin kunye nemveliso, ekhokelela kwizibonelelo ezongezelelekileyo ze-metabolic kunye nokunyamezelana kweswekile. Ngokukodwa, izongezo ze-NMN zinokunceda ukusebenza ukunciphisa imeko ye-metabolic enjengesifo seswekile, isifo sesibindi esinamafutha, kunye nokukhuluphala. [11]

 

Ezinye izibonelelo ezinokubakho zeNMN

  • Ukukhuthaza impilo yeVascular kunye nokuHamba kweGazi. [11]
  • Ukuphucula ukunyamezela kweMisipha kunye namandla
  • Ikhusela kwizifo zentliziyo
  • Ukunciphisa umngcipheko wokuTyeba kakhulu. [10]
  • Ukuphucula ukuLungiswa kweDNA
  • Yandisa iMitochondrial Function. [9]

 

Ungazinza njani, ucoceke kwaye ukhuseleke kwi-NMN?

Ukuqinisekisa ukuba imveliso ezinzileyo, ethembekileyo, esulungekileyo nekhuselekileyo inokufezekiswa njani, uthotho lweemvavanyo kunye nohlalutyo lwenziwa. Iingxelo ze-COA, HPLC kunye ne-HNMR zinokubonelelwa.

 

Uzinzo oluphuculweyo

Ngokuhlalutya ubume beNicotinamide mononucleotide kunye nokusebenzisa ukudluliselwa kwentlawulo kunye nendlela yokubeka iliso kwi-in-situ ye-FTIR, kwafumaniseka ukuba i-NMN inesakhiwo esinye setyuwa esingaphakathi kunye nenqaku le-isoelectric yetyuwa yangaphakathi yeyona nto iphambili yokungazinzi kwe-NMN. Amanzi, njengemolekyuli enye ye-polar, aya kubangela ukuhanjiswa kombane ngaphakathi kwe-NMN enokuthi itshabalalise uzinzo lwangaphakathi lwamathambo e-NMN. Ukuba kunjalo, i-NMN iyakubonisa utshintsho olwenzekayo oluthotywa lula ngokulula, oko kukuthi umxholo wamanzi kwimveliso kunye neemolekyuli zamanzi ezisimahla emoyeni ziya kutshabalalisa ngokuthe ngqo indawo ye-isoelectric yetyuwa yangaphakathi kwaye yehlise ubunyulu be-NMN. Esi sisenzo esikhulu sophando lozinzo lwe-NMN, oluya kuba sisiqalo esinye sokuphuculwa.

Ukuphucula uzinzo lwe-NMN powder ngaphakathi, abaphandi bayile ngobuchule ipowder entsha yeNMN ngolungelelwaniso nolungelelwaniso lwamalicroscopic.

 

Ukuzinza okuqinileyo, ukuhlala ixesha elide.

I-Phcoker NMN powder ilungelelene ngakumbi kwaye icwecwe, kuthintela ngokufanelekileyo unxibelelwano namanzi asimahla emoyeni, ikonyusa uzinzo lwe-NMN kwaye yandisa ubomi beshelffu yemveliso. Ngokuchasene nenoveli yamalungiselelo eNMN microscopic, ubume bokuqala be-sawtooth bubonisa ukungahambi kakuhle kunye nokungahambelani, yiyo loo nto yonke imolekyuli iya kufumana ukubonwa ngakumbi emoyeni kwaye ifunxe amanzi amaninzi.

 

Ukuxinana okuphezulu, umthamo ozinzileyo kunye nokuqulunqwa okuguqukayo.

I-NMN powder enocwangco kunye nolungelelwaniso oluncinci olunobuninzi obunobuninzi kunye nobumanzi, obuthintela umthamo ongazinzanga ngenxa yokuphakamisa uthuli kwinkqubo yokulungiselela. Ngaphezu, kuya kuchaphazela idosi efanayo njengezingxobo. Okwangoku, kuba ine-fluidity engcono, i-NMN powder yethu inokunceda ukunciphisa ixesha lokuvelisa kunye neendleko zokuvelisa ngexesha lokuvelisa.

 

Umgangatho ophezulu oqinisekisiweyo nonyulu

Iingxelo zokuvavanywa kweelebhu zomntu wesithathu kufuneka ziyimfuneko ukuze kuqinisekiswe isazisi kunye nobunyulu beNNM Ibhetshi nganye yezinto ezingafunekiyo kufuneka iphumelele ukuzihlola ngokungqongqo kunye novavanyo lomntu wesithathu. Iingxelo zovavanyo ze-HNMR kunye ne-HPLC zinokuqhubeka nokuqinisekisa ubunyani, umgangatho ophezulu kunye nokucoceka kwe-NMN.

 

I-Phcoker yiNicotinamide mononucleotide (NMN) yomenzi wepowder

Ngomzi mveliso wakho, imveliso yethu yempuphu yeNMN ifikelela ngaphezulu kweetoni ezi-2.

 

isicelo

Izinto zokuthambisa zokwenza izinto:

I-NMN yinto emzimbeni weeseli, kwaye i-NMN yimolekyuli ye-monomer, iyinto echasene nokuguga icacile, inokusetyenziswa kwizinto zokwenza izinto zokuthambisa.

 

Imveliso yokhathalelo lwempilo:

I-NMN powder inokulungiswa ngegwele, ukubumba kweekhemikhali okanye kwi-vitro enzymatic catalysis.

I-NMN powder esetyenziswa ngokubanzi kushishino lokhathalelo lwempilo.

 

Imbekiselo:

[1] Mononucleotide yeNicotinamide. Ukusuka kwiWikipedia, intyilalwazi yasimahla.

[2] Ulawulo lwexesha elide lweNicotinamide Mononucleotide Lunciphisa ukwehla okuhambelana nomzimba kwiimpuku. IiMills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Iseli yeMetab. Ngo-2016 uDisemba 13.

[3] Ukwehla kwe-NAD + kubangela iPseudohypoxic State iphazamise uNxibelelwano lweNyukliya-iMitochondrial ngexesha lokuguga. I-Gomes AP, Ixabiso le-NL, iLing AJ, iMoslehi JJ, iMontgomery MK, uRajman L, i-White JP, iTeodoro JS, i-Wrann CD, iHubbard BP, iMercken EM, iPalmeira CM, kaCabo R, i-Rolo AP, iTurner N, iBell EL, iSinclair I-DA. Iseli. Ngo-2013 uDisemba 19; 155 (7): 1624-38. ikhonkco: 10.1016 / j.cell.2013.11.037.

[4] Entsha-Ebuyiswayo-Unobangela wokuguga. UDavid Cameron. Isikolo seHarvard Medical, Iindaba kunye noPhando, nge-19 kaDisemba ngo-2013

[5] Ipokotho ebophayo ye-NAD + ebophayo elawula ukuhlangana kweprotein-protein ngexesha lokuguga. U-Li J, uBonkowski MS, uMoniot S, uZhang D, uHubbard BP, uLing AJ, uRajman LA, uQin B, uLou Z, uGorbunova V, uAravind L, uSteegborn C, uSinclair DA. Inzululwazi. Ngo-2017 ngoMatshi 24; 355 (6331): 1312-1317. ikhonkco: 10.1126 / science.aad8242.

[6] Ubungakanani bokuKhutshwa kweChromatography Indlela yokuCocwa kweNicotinamide Mononucleotide (NMN) kwiiSeli zeBacteria. UGeorge Cătălin Marinescu, uRoua-Gabriela Popescu kunye noAnca Dinischiotu. Iingxelo zeNzululwazivolume 8, Inqaku lenqaku: 4433 (2018).

[7] INicotinamide adenine dinucleotide. Ukusuka kwiWikipedia, intyilalwazi yasimahla. 2019.

[8] Ukuchongwa kwe-mitochondrial NAD + yokuhambisa kwi-Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. Ngo-2006 uJan 20; 281 (3): 1524-31. Epub 2005 uNovemba 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. IMitochondria, uxinzelelo lwe-Oxidative kunye neNkqubo yeKynurenine, egxile ekugugeni naseNeuroprotection. Iimolekyuli, i-2018; INGXELO: 10.3390 / iimolekyuli23010191.

[10] Unyango lweNicotinamide mononucleotide (NMN) luphucula ifuthe lokutyeba kakhulu koomama kwiimpuku: ukuthelekisa umthambo. U-Oddin GM, u-Youngson NA, uDoyle BM, uSinclair DA, uMorris MJ.

[11] UJun Yoshino, uKathryn F. Mills, uMyeong Jin Yoon, uShin-ichiro Imai. INicotinamide Mononucleotide, iNAD ephambili + ePhakathi, inyanga iPathophysiology yokutya- kunye nesifo seswekile esidala kwiigundane. Iseli yeMetab, 2011; INGXELO: 10.1016 / j.cmet.2011.08.014.

[12] Iziyobisi zamandulo zokulwa noguga: I-Nicotinamide Mononucleotide (NMN)