Tadalafil powder (171596-29-5)

Oktobha 20, 2018

Singumenzi omkhulu weTadalafil powder eChina


Isimo: KwiMveliso yoLuntu
Iyunithi: 25kg / Drum
Amandla: 1190kg / inyanga

Tadalafil powder video

 

Ulwazi loLwazi

Igama lemveliso Tadalafil powder
Igama leKhemikhali (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
uhlobo Numama Cialis, Adcirca
Iqela leziyobisi I-PAH, i-PDE-5 Inhibitors; I-Phosphodiesterase-5 Enzyme Inhibitors
Inani leCAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
I molecular Fi-ormula C22H19N3O4
I molecular WSibhozo 389.4
IMasaisotopic Mass 389.138 g / mol
Ukuxuba Point  298-300 ° C
Fukuhlaziywa kwakhona Point 2 ℃
I-Biological Half-Life iiyure 17.5
umbala Umhlophe ukuya kwi-Cyrstalline Solid Off-White
Sukufaneleka  I-Soluble kwi-DMSO (78 mg / ml kwi-25 ° C), i-methanol, amanzi (<1 mg / ml kwi-25 ° C), i-dichloromethane, kunye ne-ethanol (<1 mg / ml kwi-25 ° C)
Sisibetho Tukushisa  Gcina kubushushu begumbi phakathi kwe-59 ° F kunye ne-86 ° F (15 ° C kunye ne-30 ° C). Sukuyigcina le yeyeza kwindawo efumileyo okanye efumileyo.
Tadalafil Aukuguquka Amaphilisi amadaka e-Tadalafil amancinci, i-candy yezocansi, ikhofi yesondo, njl.

 

Tadalafil Powder

Ukungasebenzi kakuhle kwe-Erectile kukuphazamiseka okuxhaphakileyo ngokwesini emadodeni achaphazela malunga neepesenti ezingama-52 zamadoda ngaphezulu kweminyaka eli-18, kwihlabathi liphela. Ukwahluka ngamandla, ukungasebenzi kakuhle kwe-erectile kuhlala kubangelwa kukuhla kwegazi kwimithambo yegazi ye-penile, elona nyathelo liphambili kwimveliso yolwakhiwo. 

Ukungasebenzi kakuhle kwe-erectile sisifo esilawulwa ngokupheleleyo nesinyangekayo ngamayeza ahlukeneyo ajolise kwii-enzyme ezikhethekileyo eludongeni lwemithambo yegazi ye-penile. Olunye lonyango olunamandla kwi-ED yiTadalafil powder enesiqingatha sobomi beyure eziyi-17.5. 

 

Yintoni iTadalafil Powder?

I-Tadalafil Powder yeyeklasi yokuvuselela ngokwesondo njengoko iyeza liyilelwe amadoda angaphezu kweminyaka ye-18, enengxaki yokungasebenzi kakuhle kwe-erectile. I-Tadalafil, okanye (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6 , 3,4] pyrido [1,4-b] indole-XNUMX-dione sisiyobisi esifana neSildenafil okanye iViagra, isenzo, kodwa sahlukile kubume. I-Tadalafil nayo yahlukile kunyango oluqhelekileyo lwe-erectile dysfunction, iViagra, kwi-potency njengoko inamandla ngakumbi kwaye isebenza ngokufanelekileyo kunale yokugqibela. 

I-Tadalafil Powder sisiyobisi se-PDE5 inhibitor, oko kuthetha ukuba ijolise kwi-enzyme yePDE5 efumaneka kwiiseli zemisipha egudileyo yemithambo yegazi ye-penile. Umsebenzi wothintelo lonyango uluncedo kakhulu njengoko eyona njongo iphambili ye-enzyme kukubangela i-vasoconstriction, ethi kwimithambo yegazi ye-penile, ikhokelele ekunciphiseni ukuhamba kwegazi kwaye ngenxa yoko ukungasebenzi kakuhle kwe-erectile. 

I-Tadalafil Powder yenziwa yi-Pharmax Lifesciences kwaye inokusetyenziselwa unyango olungaphezulu kokungasebenzi kakuhle kwe-erectile. I-Tadalafil Powder ikwabhalelwe amadoda aphethwe yi-benign prostatic hyperplasia kunye ne-pulmonary arterial hypertension. Nangona kunjalo, iTadalafil Powder ayisebenzi kunyango lokunye ukuphazamiseka kwezesondo kumadoda nabasetyhini. 

 

Iifom zeTadalafil

I-Tadalafil sisixhobo esinamandla se-PDE5 inhibitor, esifumaneka ngeendlela ezahlukeneyo kunye needosi, esenza ukuba ukusetyenziswa kwayo kube lula kwizigulana. Amayeza ayafumaneka ngohlobo lweepilisi okanye iipilisi, idosi iyi-5 mg, 10 mg, kunye no-25 mg. Kubalulekile ukuba uqaphele ukuba idosi yeTadalafil yahlukile ngokusekwe kwinkampani yokuvelisa. 

I-Tadalafil ikwafumaneka kwifom yomgubo, nangona ithengiswa kakhulu kusetyenziselwa imveliso. Esi sesona sizathu siphambili sokuthenga i-Tadalafil Powder kwiivenkile ezinkulu ezaziwa kakhulu ngolu hlobo lweziyobisi. Le fomu ihlala ithengiswa kwizikhongozeli ezingama-25 kg ukuya kuma-50 kg, kuxhomekeke kwimfuno zevenkile ethengisa ukutya. 

Umthamo ngokubanzi weTadalafil powder, ukuqala ngawo, yi-10 mg. Elona dosi liphezulu, ngaphakathi kweeyure ezingama-24, ngama-20 mg, kwaye ukugqitha kule dosi akukhuthazwa.

Eli yeza likhuselekile ukuba lingasetyenziswa ngabantu njengoko lifumene ukuvunywa kunye nokuvunywa yi-FDA evela kubaphathi bezeMpilo baseIndiya, baseCanada, baseAustralia nabaseBritane. I-FDA yavuma ukusetyenziswa kweepilisi zeTadalafil ngonyaka we-2002, kwaye kungekudala emva koko, ukusetyenziswa kwe-tadalafil powder kwavunywa yi-FDA nayo. 

Umzimveliso weTadalafil owenza umzi-mveliso ubanga ukuvelisa amayeza anikwa amayeza kuphela ngokuchanekileyo. Abavelisi baluqwalasele kakhulu ukhuseleko lomntu, olucaciswe gca kumandla, ukhuseleko, kunye nokusebenza kwemveliso yokugqibela. 

 

Isebenza njani iPowfilfil Powder?

I-Tadalafil Powder iqulethe i-Tadalafil, i-PDE5 inhibitor compound eyayiphandwa kuqala kwaye yenziwa nguGlaxoSmithKline emva kokufunyanwa kweSildenafil, ikhompawundi efanayo. I-Sildenafil, kwelinye icala, yayiqala yophando njengonyango lwe-angina kunye noxinzelelo lwegazi kodwa isifundo sonke sachithwa emva kokungaphumeleli kwizigaba zokuqala zesifundo. Nangona kunjalo, kuphononongo, kwafunyaniswa ukuba uSildenafil angakwazi ukuvelisa ii-erections ukuba abaguli bavuselelwe ngokufanelekileyo ngokwesondo.

Njengoko i-sildenafil iyi-PDE5 inhibitor, uGlaxoSmithKline uthathe isigqibo sokwenza uluhlu olubanzi lokukhangela kwiikhompawundi ngendlela efanayo ne-Sildenafil. Olu phando lukhokelele ekufumanekeni nasekuphuhlisweni kweTadalafil. 

I-Tadalafil sisixhobo esinamandla se-PDE5 inhibitor esinesiqingatha sobomi seeyure eziyi-17.5 ezithatha malunga neeyure ezingama-96 ukucoca ngokupheleleyo emzimbeni womntu. Xa kuthelekiswa nepilisi eqhelekileyo eluhlaza okwesibhakabhaka, iViagra, esebenza kuphela iiyure ezingama-3 ukuya kwiiyure ezi-4 emva kokungenisa, iTadalafil iphuma ngaphezulu. 

Owona msebenzi uphambili wokusebenza kwesiyobisi uthintela i-enzyme ye-PDE5 ekhoyo kwiiseli zemisipha egudileyo yemithambo yegazi ye-penile. Ukuthintela le enzyme kukhokelela ekuphuculweni kwe-vasodilation kwaye ekugqibeleni, ukwanda kokuhamba kwegazi kwimithambo yegazi, ejikelezwe yi-corpus cavernosa. Esi sihlunu sobudoda, xa sifakwa phantsi koxinzelelo ngokwanda kokuhamba kwegazi, sinyanzelwa ukuba sime nkqo, ekubhekiswa kuso njengokwakhiwa.

Nangona kunjalo, izihlunu ze-penile, i-corpus cavernosa ukuba ichaneke, kufuneka iqale ikhululeke ukuze imithambo yegazi ikwazi ukwandiswa kwaye ifumane igalelo eliphezulu legazi. Ukuphumla kwezihlunu ezigudileyo ikwayimpembelelo ye-enzyme ye-PDE5, nangona ingangqalanga. Ukuthintela iziphumo ze-PDE5 kwinani elonyukayo leGuanosine MonoPhosphate okanye i-GMP, ebalulekileyo ekuhlaziyeni izihlunu ezigudileyo, ezinje ngecorpus cavernosa. 

Nangona kunjalo, ayisiyiyo kuphela ukusetyenziswa kunye nendlela yokusebenza kweTadalafil Powder. Iyeza elinikwa amayeza kuphela lisetyenziselwa i-benign prostatic hyperplasia, ukuphazamiseka komchamo okubangelwa kukwandiswa kwe-Prostate gland kunye nokubonisa njengokuchama okubuhlungu. Indlela yokusebenza yonyango eyandisiweyo ye-Prostate gland ikwanyusa amanqanaba e-GMP kwiiseli zemisipha egudileyo. Ukuphumla kwezi seli kuvumela indlela elula yokuchama kunye nokuthintela ukugcinwa komchamo kunye neentlungu. 

I-Tadalafil Powder ikwacwangciselwe i-pulmonary arterial hypertension, njengoko i-PDE5 inqanda ukusebenza kungekuphela kokunyusa ukuhamba kwegazi kodwa ikwanciphisa uxinzelelo lwegazi, oluncedo kakhulu kunyango lwe-PAH. 

 

Inokusetyenziselwa ntoni Powder yeTadalafil?

I-Tadalafil Powder isetyenziselwa unyango kwezi meko zilandelayo:

  • Dysfunction Erectile
  • IBenign Prostatic Hyperplasia 
  • Uxinzelelo lwegazi lwePulmonary Arterial

Nangona uphando luqhutywa kusetyenziso olutsha olunokubakho lwamayeza, okwangoku kuphela kwenzelwe ukuba kunikwe amadoda angaphezulu kweminyaka eli-18, enengxaki yokuphazamiseka okuchazwe apha ngasentla. Ngokuqhelekileyo, iyeza lisetyenziselwa unyango lwe-erectile dysfunction. 

 

Izibonelelo zeTadalafil Powder

I-Tadalafil inezibonelelo ezininzi iyodwa kwaye xa ithelekiswa nezinye ii-PDE5 inhibitors zodidi lweziyobisi ezikhuthaza isondo. Eli yeza linamandla kwaye lihlala ixesha elide njengoko kuthatha iiyure ezingama-36 ukuba zicinywe kwinkqubo, kuphela kungenakulandelwa emva kweeyure ezingama-96. Iziphumo zeziyobisi ziyabonakala kwaye zibonakale zijikeleze imizuzu ye-20 ukuya kwimizuzu ye-60 emva kokungenisa, kunye neTadalafil powder ihlala isebenza malunga neeyure ezi-3 ukuya kwiiyure ezi-4 emva. Kubalulekile ukuba ukhankanye ukuba umsebenzi weziyobisi awulinganisi nangayiphi na indlela nexesha lokwakhiwa. 

I-Tadalafil Powder ayinakho ukuvelisa izinto ezizenzekelayo kunye neemfuno ezifanelekileyo zesondo kunye nokuvuselela ukuze isebenze ekuveliseni ulwakhiwo. Ukuba ukuvuselelwa ngokwesondo kubonelelwa ngexesha leeyure ezine kulandela ukungeniswa kwamayeza, iyeza linokuvelisa ulwakhiwo kunye nokunciphisa iimpawu zokungasebenzi kakuhle emzimbeni. 

Eli chiza livuselelayo ngokwesini liyasebenza ekunyangeni ukungasebenzi kakuhle kwe-erectile njengesiphumo sendlela yokusebenza eqhubeka ixesha elide, eyenza ukuba ibe sisiyobisi esithandwayo kubantu abaninzi abanengxaki yokungasebenzi kakuhle kwe-erectile kunye ne-benign prostatic hyperplasia. I-Tadalafil Powder inokudityaniswa neTamulsin, elinye ichiza elinamandla kunyango lwe-benign prostatic hyperplasia nangona ukusebenza kwalo mxube weziyobisi kusafundwa kwaye kuhlolisiswa. 

 

Isisombululo esifanelekileyo seTadalafil Powder

I-Tadalafil Powder, njengoko kuchaziwe apha ngasentla, ihlala iqalile kwi-10 mg njengeyona dose iphantsi kakhulu. Emva kweveki ubuncinci usebenzisa amayeza, idosi inokuncitshiswa, inyuswe, okanye igcinwe kumanqanaba afanayo kuxhomekeke kwiziphumo. Nangona kunjalo, kubalulekile ukuba ugcine engqondweni ukuba eli yeza lonyango kuphela emiselweyo ekufuneka isetyenziswe kuphela xa ifuneka. Kuya kufuneka isetyenziswe kube kanye kwiiyure ezingama-24 ukuze kungongezwa miphumo mibi yamayeza.

Umngcipheko wedosi ephosiweyo kunyango ekufuneka ukuba luthathwe kuphela xa lufuneka phantse alukho nangona kunjalo, kubalulekile ukucacisa izikhokelo zedosi ephosiweyo. Kungenxa yokuba iyeza limiselwe ukusetyenziswa mihla le, ubuncinci kathathu ngemini xa lisetyenziselwa unyango lwe-pulmonary artery hypertension kunye ne-benign prostatic hyperplasia. Kwimeko yethamo elilahlekileyo, kungcono ukunqanda loo dosi ngokupheleleyo, kwaye naphantsi kwazo naziphi na iimeko kufuneka ukuba idosi ephosiweyo ibuyiselwe idosi ephindwe kabini kwixa elizayo. Oku kunokukhokelela kwiziphumo ezinde kakhulu nezingafunekiyo ezinokubangela iingxaki ezibulalayo. 

 

Ngubani ongafanele asebenzise iTadalafil Powder

I-Tadalafil Powder inezibonelelo ezahlukeneyo kunye nokusetyenziswa kodwa yenzelwe ngokukodwa isini sendoda, ngakumbi abo bangaphezulu kweminyaka ye-18. Amayeza akufuneki athathwe ngabafazi nabantwana njengoko benokuba semngciphekweni omkhulu wokukhula kweziphumo ebezingalindelekanga eziqhelekileyo kunye neengxaki ezinxulumene nokusetyenziswa kwamandla eTadalafil. 

Aba bantu balandelayo akufuneki bathathe iTadalafil Powder, okanye babonane nogqirha ngaphambi kokuba baqale naliphi na iyeza le-PDE5 inhibitors yeklasi yeziyobisi:

  • Abantu abanembali yokungenelela kotyando kwezi nyanga zintathu zidlulileyo
  • Abantu abanembali yeziganeko zentliziyo kwiinyanga ezintathu ezidlulileyo ukuya kwiinyanga ezintandathu
  • Abantu abanexinzelelo lwegazi kunye ne-hyperlipidemia
  • Abantu abanezifo zezintso
  • Abantu abane-retinitis pigmentosa
  • Abantu abane-hemophilia okanye ukuphazamiseka kwegazi okufanayo
  • Abantu abane-myeloma, okanye i-leukemia
  • Abantu abanezilonda esiswini
  • Abantu abanembali yestroke okanye abanomngcipheko okhulayo wokuba ne-stroke

Aba bantu abavumelekanga ukuba bathathe iTadalafil kuba amayeza abo akhoyo ngoku anokusebenzisana neziyobisi, oko kukhokelela kwiingxaki ezisongela ubomi. Ngamanye amaxesha, le mizimba yezigulana inokuba sesichengeni sokufumana iziphumo ebezingalindelekanga eziqhelekileyo kodwa ezingabalulekanga kweziyobisi kodwa ubunzima beengxaki zinokuba ngaphezulu kunesiqhelo. 

 

Iziphumo ebezingalindelekanga ezinokubakho zePadalafil Powder

I-Tadalafil Powder, njengamayeza amaninzi, ineempembelelo eziqhelekileyo eziqhelekileyo ezinxulumene nokusetyenziswa kwayo. Nangona kunjalo, akukho namnye kubo onobuzaza, imisebenzi yemihla ngemihla eguqukayo, okanye esongela ubomi. Ngapha koko, uninzi lwazo luya kusombulula lodwa kwaye aluyi kufuna ungenelelo lonyango. 

Iziphumo eziqhelekileyo zeTadalafil zibandakanya, kodwa azikhawulelwanga:

  • Stuffy ekhaleni
  • Intloko
  • Dyspepsia
  • Isisu esibuhlungu
  • Ukugungxula; ukufudumala nokubomvu kwesikhumba
  • Tinnitus; Isandi esiqhubekayo sokukhala kwindlebe
  • Iingxaki zokuva
  • Umbono ogqabileyo
  • Ukuphulukana nombono
  • Ukuzikhethela

Iziphumo zokugqibela zecala zinobuzaza ngakumbi kwaye zibhekisa kulwakhiwo olude kunye nolubuhlungu esele luhleli, zihlala ngaphezulu kweeyure ezine. Kwiimeko ezinjalo, kuyacetyiswa ukuba ufune uncedo lwezonyango kwangoko njengoko kuyinto ebaluleke ngakumbi, nangona inqabile, isiphumo sokusetyenziswa kweTadalafil. 

Ukusukela ngo-Okthobha ka-2007, i-FDA ifuna zonke izikhongozeli ze-PDE5 inhibitor iziyobisi ukuba zibandakanye ilebhile yesilumkiso evumela abasebenzisi ukuba bazi ukuba la mayeza anokubangela ilahleko yethutyana ngequbuliso. Esi sigqibo yi-FDA sisiphumo sezikhalazo ezininzi zokulahleka kokuva kwizigulana ezisebenzisa iTadalafil okanye iziyobisi ezifanayo ezibhaliswe kwi-FDA, ezifuna ukuba ziwuhlalutye kakuhle umba. Uphando lwe-FDA lufumene ilahleko yokuva ukuba sisiphumo esibi se-TAdalafil abakholelwa ukuba zonke izigulana kufuneka zaziswe, ngokucacileyo, ukuze bakwazi ukwenza isigqibo esifanelekileyo. 

Ukulahleka kombono yayisesinye isikhalazo esihlala sinxulunyaniswa nokusetyenziswa kweTadalafil kwaye xa i-FDA ijonge kwezi zikhalazo, kwafumaniseka ukuba le mpembelelo yecala yayisenzeka kakhulu kwizigulana esele zinengxaki yokugula kwamehlo, ezizezi non-arteritic anterior ischemic optic neuropathy okanye NAION. Kuba kwakungekho sizathu ngqo kunye nesiphumo esifunyenwe yi-FDA, akukho ilebhile yesilumkiso enxulumene nelahleko yombono kwiTadalafil powder okanye ezinye i-PDE5 inhibitors ezipakisha iilebheli. 

 

Ukudibana kwesiyobisi esiqhelekileyo kunye neTadalafil Powder

Amayeza athile akufuneki ukuba athathwe kunye njengoko enokunxibelelana nesiphumo ngasinye sokuhla kokubini, isiphumo esonyukayo sobabini, okanye ukonyusa iziphumo ezibi kuwo omabini amayeza. 

I-Tadalafil Powder yenye yezo nyango ezingafanelekanga ukuba zithathwe kunye nala mayeza alandelayo.

  • I-Antacids: La mayeza ayasebenzisana neTadalafil kangangokuba akhokelela ekunciphiseni ukusebenza kwesiyobisi samva, nangona indlela eyiyo ingekaqondwa. Nangona kunjalo, kubalulekile ukuba ulumkise abaguli malunga nokunxibelelana okunokwenzeka phakathi kwala mayeza mabini, ngakumbi njengoko ichiza langaphambili liyeza lasekhaya eliqhelekileyo. 
  • I-PDE5 Inhibitors: Ukusetyenziswa kweziyobisi ngendlela efanayo neTadalafil kunokubangela ukonyuka okubonakalayo kokuhamba kwegazi kunye nokwehla okusongela ubomi koxinzelelo lwegazi. Ukudibanisa ezimbini ezahlukeneyo ze-PDE5 inhibitors okanye ukuthatha idosi ephindwe kabini yechiza elifanayo kunokubangela iingxaki endaweni yezibonelelo ezongezelelweyo. 
  • Utywala: Ukuthatha i-Tadalafil powder ngotywala akunakubangela naziphi na iingxaki ezithile kodwa kunokubangela ukonyuka okukhulu kubungakanani beziphumo ebezingalindelekanga. Zingaqheleka ukwenzeka kodwa xa ziqinisiwe, zinokunyamezeleka kwaye zifuna uncedo lonyango. 
  • AmaNitrate: La mayeza asetyenziselwa iinjongo zentliziyo kunye nomsebenzi wawo ophambili kukonyusa ukuhamba kwegazi kwimithambo yegazi ngokuba nefuthe le-vasodilatory kubo. Le ndlela yokusebenza ifana naleyo yeTadalafil, yiyo loo nto ukudityaniswa kwamachiza amabini kukhokelela ekubaxeni kweziphumo ezibi kuwo omabini la machiza.
  • Anti Hypertensives: Isizathu soku siyinto efanayo naleyo yee-nitrate. I-anti hypertensives kunye neTaladafil zombini zisebenza ekunciphiseni uxinzelelo lwegazi ngemithambo ye-vasodilating, enokuthi xa idibene kunye, ibangele uxinzelelo lwegazi olusezantsi kakhulu olunokubangela ukusweleka, ukuba luyekwanga lunganyangwa.
  • I-CYP3A4 i-Inducers: I-CYP3A4 yi-enzyme ejongene nokukhutshelwa kwecandelo leTadalafil emzimbeni emva kokuba isebenze injongo yayo. Nangona kunjalo, iyeza elonyusa iziphumo zale enzyme liya kuthi ngenxa yoko likhokelele ekunyukeni kweTadalafil, kwangaphambi kokuba ikwazi ukuzalisekisa injongo yayo. Oku kwenza ukuba le yokugqibela ingasebenzi kwaye ingenamsebenzi. 
  • I-CYP3A4 Inhibitors: Nasiphi na isiyobisi esithintela isenzo se-CYP3A4 enzyme sinokukhokelela ekunciphiseni ukukhutshwa kweTadalafil eya kuyishiya kwinkqubo yabantu ixesha elide kunokuba liyimfuneko. Iziphumo ezide azifuneki kwaye zinokuba yingozi xa zizonke, yiyo loo nto indibaniselwano yezi zimbini kufuneka ithintelwe kuzo zonke iindleko. 
  • I-Guanylate Cyclase Stimulators: La mayeza ajolise kwimisipha yemiphunga, ejolise ukunciphisa uxinzelelo lwegazi elihamba ngayo. Nangona kunjalo, leyo yenye yeempembelelo eziluncedo kunye nokusetyenziswa kweTadalafil. Ukuthabatha ezi zinto zimbini kunye kunokubangela uxinzelelo lwegazi oluphantsi kakhulu, olunokubulala ukuba alunyangwa ngokufanelekileyo nangokufanelekileyo. 

 

Uphi uthengiswa ngePadalafil Powder?

I-Tadalafil Powder ukurhweba ngokuthengisa ngokubanzi kuxhaphake kakhulu kunentengiso yentengiso njengoko ihlala ithengwa ngobuninzi ngokuthe ngqo kumzi mveliso weTadalafil Powder. Ngokubanzi, amayeza endalo yabucala ahlala ethengwa kwi-Intanethi njengoko ibonelela abaguli ngokubona kunye nemfihlo abayifunayo. Iyeza liyafumaneka phantse kuzo zonke iikhemesti zalapha ekhaya nakwi-Intanethi kodwa abaguli kufuneka babe nephepha likagqirha ukuze bakwazi ukulithenga. 

 

Uphando oluqhubekayo lwezonyango kunye nolwazi

I-Tadalafil iphandwa rhoqo kwaye ifundelwa ukuvavanya naluphi na olunye usetyenziso lwamayeza. I-Tadalafil sisixhobo esiphambili kumachiza amiselweyo ohlukeneyo, onke athengiswa phantsi kwamagama eempawu ezahlukeneyo, ubukhulu becala kukuphazamiseka okunjenge-erectile dysfunction, i-benign prostatic hyperplasia, kunye ne-pulmonary arterial hypertension. Nangona kunjalo, kukho izifundo ezahlukeneyo kwizigaba zabo zokuqala eziye zabonisa ukuba iTadalafil, kwixa elizayo, inokumiselwa nakwezinye iingxaki. 

Esinye sezifundo ezibaluleke kakhulu ezenziwa kwiTadalafil sigxile ekusebenzeni nasekukhuselekeni ukuba sisetyenziswa mihla le zizigulana ezinengxaki yokungasebenzi kakuhle. Uphononongo lupapashwe kwiJenali yezeMpilo yaseIndonesia, kwaye ngokusekwe kuhlalutyo loncwadi olusuka kulwazi lwe-elektroniki, kwagqitywa kwelokuba ukusebenzisa iTadalafil kube kanye ngemini kusebenza ngakumbi ekunyangeni ukungasebenzi kakuhle kunokusetyenziswa kweyeza xa kufuneka njalo. 

Isizathu sokuba olu phononongo lubaluleke kakhulu kukuba inokubanakho ukutshintsha iiprotocol zonyango kunyango lwe-erectile dysfunction. Nangona kunjalo, ezinye izifundo kufuneka zenziwe ngaphambi kokuba kwenziwe utshintsho kwizicwangciso zonyango. 

Olunye uphando olwenziwe kwiTadalafil lujolise ekubuyiseleni kwiziyobisi ezikhuthaza isondo, kunye neziyobisi ezikudidi olunye, i-vardenafil, eza kusetyenziswa kunyango lweengxaki zamathambo. Ukuphazamiseka kwethambo apha kubhekisa kukuphazamiseka apho i-osteoclast okanye iiseli ezitshabalalisa amathambo zisebenza ngesantya esiphezulu kwaye ngokukuko ngokungenakuthelekiswa nanto nokusebenza kwe-osteoblast okanye iiseli ezenza amathambo. Oku kubangela ukwehla kwamathambo okwenza ukuba izigulana zichaphazeleke kukophuka komzimba. 

Kwisigaba se-vivo sophononongo lubonise ukuba omabini la machiza awanokwandisa kuphela umsebenzi wee-osteoblast kodwa kwangaxeshanye anciphise umsebenzi wee-osteoclasts. Amachiza ayakwazi ukwenza oku kuba indlela ye-PDE5A yeyona nto iphambili ekuveliseni ulungelelwaniso lwazo zombini iintlobo zeeseli. Indlela efanayo yile nto iziyobisi zijolise kuzo kunyango lwe-erectile dysfunction. Emva kokusetyenziswa kwe-vivo iikhonsepthi kwiimodeli zezilwanyana ngabaphandi abakhokela kolu phando, kwafunyaniswa ukuba omabini la machiza anokukhetha okunokwenzeka kulawulo lwethambo elinobunzima. Nangona kunjalo, ezinye izifundo kufuneka zenziwe kwiziphumo zazo zombini iziyobisi kubunzima bethambo labantu.  

Uhlalutyo lwe-meta olupapashwe kwi-Endocrinology Journal xa kuthelekiswa nokusebenza konyango lwe-tadalafil, unyango lwe-tamsulosin, kunye ne-tamsulosin kunye nonyango lwe-tadalafil ekuncedeni ukugxothwa kwamatye e-urethral. Injongo yesifundo yayikukufumana kungekuphela nje iindlela zonyango zokudibanisa ukunceda abaguli abanamatye okubuyisa kodwa nokuvavanya ukhuseleko kwezi zicwangciso zonyango. 

Ukusetyenziswa kwe-tadalafil yodwa okanye i-tadalafil kunye ne-tamsulosin zezona zikhetho zibini ezifumaneke ukuba zezona zinempumelelo kwaye zinokubanamandla okuvelisa isiphumo esibi. Ngaphaya koko, iimpembelelo zeTadalafil zinokunciphisa iintlungu ezininzi kwizigulana ezinamava e-ureteral ngelixa ichiza likwanceda ukukhupha ilitye kwinkqubo.