Urolithin A.

Aprili 8, 2021

I-Urolithin A ibonakalisiwe ukukhuthaza i-mitophagy kunye nokuphucula impilo yemisipha kwizilwanyana ezindala nakwiimodeli zangaphambi kokuguga. Okwangoku, ikwabonakalisiwe ukuba inqumle isithintelo sobuchopho begazi, kwaye inokuba nefuthe le-neuroprotective ngokuchasene nesifo se-Alzheimer's.

I-Urolithin A (1143-70-0) ividiyo

Urolithin A (1143-70-0)iinkcukacha

Igama lemveliso I-Urolithin A powder
Igama leKhemikhali 3,8-dihydroxy-6H-benzo [c] chromen-6-inye;

3,8-Dihydroxy-6H-dibenzo (b, d) ipyran-6-nye;

I-3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-inye;

6H-Dibenzo [b, d] pyran-6-inye, 3,8-dihydroxy-;

I-3,8-Hydroxydibenzo-alpha-pyrone;

Inani leCAS 1143-70-0
InChIKey I-RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
I molecular Fi-ormula C13H8O4
I molecular WSibhozo 228.2 g / mol
IMasaisotopic Mass 228.042259 g / mol
Indawo yokunyibilika 340-345 ° C
Indawo yokubilisa  527.9 ± 43.0 ° C (Kuxelwe kwangaphambili)
Indawo yokuflasha 214.2ºC
I-Biological Half-Life I-Urolithin A ikho kumchamo ukuya kuthi ga kwiiyure ezingama-48 emva kokusetyenziswa kwerharnati.
umbala Mhlophe ukuya kwi-beige
Sukufaneleka  I-DMSO: 20 mg / mL, icacile
Sisibetho Tukushisa  2-8 ° C
Aukuguquka Isetyenziswe njengesongezelelo sokutya kunye nemveliso yokuguga, ingasetyenziselwa ukunciphisa ukudumba kunye nokulwa nomhlaza;

 

Imbekiselo:

[1] UGarcia-Munoz, uCristina; UVaillant, uFabrice (2014-12-02). "Isiphelo seMetabolic se-Ellagitannins: Iziphumo zeMpilo, kunye nePhando lokuPhanda ngokutya okuSebenzayo okusebenzayo". Uphengululo oluBalulekileyo kwiSayensi yezoKutya kunye nesondlo. 54 (12): 1584-1598. ikhonkco: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. IINKCUKACHA:

[2] URyu, D. okqhubekayo. I-Urolithin A induces mitophagy kwaye iyolula ubomi kwi-C. elegans kwaye yonyusa ukusebenza kwemisipha kwiintonga. Nat. IMed. 22, 879-888 (2016).

[3] "Isaziso se-FDA GRAS GRN No. 791: urolithin A". Ulawulo lokutya kunye neziyobisi e-US. 20 Disemba 2018. Ibuyiswe ngomhla wama-25 Agasti 2020.

[4] Singh, A .; UAndreux, uP.; UBlanco-Bose, W.; Ryu, D.; Aebischer, P.; I-Auwerx, J.; I-Rinsch, C. (2017-07-01). "I-urolithin A elawulwa ngomlomo ikhuselekile kwaye imodareyitha i-biomarkers ye-muscle kunye ne-mitochondrial kubantu abadala". Ubutsha ekwaluphaleni. 1 (suppl_1): 1223–

[5] UHeilman, uJacqueline; UAndreux, uPénélope; Tran, Nga; Rinsch, uChris; UBlanco-Bose, uWilliam (2017). "Uvavanyo lokhuseleko lwe-urolithin A, imetabolite eveliswe sisisu somntu microbiota ekutyeni okutyayo izityalo ezivela kwi-ellagitannins kunye ne-ellagic acid". Ukutya kunye neChemical Toxicology. I-108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. IINKCUKACHA: