Yintoni ipyrroloquinoline quinone (pqq)?

IPyrroloquinoline quinone (PQQ) ekwabizwa ngokuba yi-methoxatin sisithako esine-cofactor efumaneka ngokutya kwizityalo ezininzi. I-PQQ nayo yenzeka ngokwendalo kubisi lwebele lomntu nakwizicubu ezincelisayo.

Nangona kunjalo, ifumaneka kuphela kwimilinganiselo yemizuzu kwindawo yokutya ubuninzi be-pqq yomgubo imveliso iyimfuneko ukufumana isixa esaneleyo emzimbeni.

I-PQQ yaqala ukufunyanwa njenge-coenzyme kwiibhaktheriya ezinomsebenzi ofana nowe-B-Vitamin ebantwini, kwaye zidlala indima ekukhuthazeni ukukhula kwezi zinto.

Kubantu, isebenza njengento engakhuli yevithamini enezibonelelo ezininzi zezempilo.

Indlela yokuSebenza

I-Pyrroloquinoline quinone (pqq) ibonisa izibonelelo ezininzi zempilo ngeendlela ezahlukeneyo njengommiselo weendlela zokungena kwiiselula, ukulahla i-radicals yasimahla kunye nomsebenzi weRox.

Iindlela zokwenza i-pqq zibandakanya:

• ichaphazela indlela yokusebenza kwemfuza

I-Pyrroloquinoline quinone inokuchaphazela indlela iintlobo zemfuza ezivezwa ngayo ingakumbi iintlobo ezibandakanyekayo kwimisebenzi ye-mitochondria. Umsebenzi wayo we-antioxidant kuthiwa ungama-100 amaxesha e-Vitamin C.

Ukongezwa kwe-PQQ kubonisiwe ukwenza ukuba i-CREB kunye ne-PGC-1a isayine iindlela ezibonisa ukubandakanyeka ngqo kwi-mitochondria biogeneis.

Yenza njenge-antioxidant

Umsebenzi we-Pyrroloquinoline quinone (pqq) anti-oxidative ubangelwa ikakhulu kukukwazi kwayo ukuncitshiswa kwi-PQQH2 ngokusabela kunye neearhente ezincitshisiweyo ezifana ne-cysteine, glutathione okanye nicotinamide adenine dinucleotide phosphate (NADPH).

• Ithintela ii-enzymes

Ipyrroloquinoline quinone iyayithintela i-enzyme Ukunciphisa kwakhona kwe-thioredoxin 1 (TrxR1), ethi iguqule imisebenzi ye-erythroid 2-N-factor 2 ehambelana ne-Nrf2 ekhuthaza ukuveliswa kwe-antioxidant.

I-PQQ ikwayaziwa ukuthintela ukukhula kwe-quinoproteins (iiprotein ezonakalisayo) ezikhokelela ekungongeni kweParkinson.

Ezona ziphumo zibalulekileyo (PQQ) pyrroloquinoline quinone

Kukho izibonelelo ezininzi zepinroloquinoline quinone kubandakanya:

i. I-PQQ ikhuthaza umsebenzi we-mitochondrial

I-Mitochondria zii-organelles ezivelisa amandla kwiiseli ezikwimo ye-ATP ngokuphefumla kweselula. Zihlala zidluliselwa kumagumbi okugcina amandla eseli okanye iifektri zamandla.

Ukuveliswa kwamandla sisitshixo sobomi obunempilo.

Ukudakumba kwe-Mitochondrial kudityaniswe neqela lokuphazamiseka njengokukhula okucothisiweyo, ubuthathaka bemisipha, ukuphazamiseka kwemithambo-luvo njengesifo sentliziyo, uxinzelelo kunye nesifo seswekile phakathi kwezinye iimeko zempilo.

I-Pyrroloquinoline quinone iphucula umsebenzi we-mitochondrial ngokunyusa ukuveliswa kweeseli ezintsha ze-mitochondria (mitochondrial biogenesis). Oku kwenzeka ngokuvula kwenkqubo yokuphendula ye-CAMP ebopha iprotein 1 (CREB) kunye nePeroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, iindlela ezikhulisa i-mitochondrial biogenesis.

I-Pyrroloquinoline quinone ikwanyusa nezinto ezikhutshelweyo ezisebenza njenge-antioxidants ngaphakathi kwe-mitochondria kungoko isikhusela kuxinzelelo lwe-oxidative.

I-Pqq iphinda ibangele ii-enzymes kwi-mitochondria eyonyusa imveliso yamandla.

Kwimodeli yerat, ukusilela kwe-PQQ ekutyeni kuye kwabikwa ukunciphisa ukusebenza kwe-mitochondrial.

Izibonelelo zepinroloquinoline quinone

ii. Uxolelwa kukuvuvukala

Ukusuleleka okungapheliyo kukwingcambu yeengxaki ezininzi ezifana nesifo sentliziyo kunye neswekile. I-Pyrroloquinoline quinone ine-antioxidant iipropathi ezinceda ukuba zisuse i-radicals yasimahla ngaloo ndlela ithintela ukuvuvukala kunye nokulimala kweseli.

Olunye uphando lubonisa oko Ukongezwa kwe-PQQ kukhokelela ekwehleni okumangalisayo kwamanqaku amaninzi okusasazeka anjenge-nitric oxide kwiintsuku ezintathu.

Kuphononongo lweempuku eziphethwe sisifo samathambo, i-PQQ eyaliswayo kwathiwa inika ukhuselo nxamnye nokuwohloka komzimba emva kweentsuku ezingama-45.

iii. Ukuphucula impilo yengqondo kunye nokusebenza

I-Pyrroloquinoline quinone inamandla okukhulisa ubuchopho kwakhona (neurogeneis) ngokuvelisa izinto ezininzi zokukhula kwe-nerve.

Olunye uphando lwagqiba ukuba i-pqq isongezelelo ivuselela ukukhula kwe-nerve factor (NGF) synthesis kunye neeseli ze-neuron.

I-Pyrroloquinoline quinone inxulunyaniswe nememori ephuculweyo kunye nokufunda ngenxa yokubanakho ukuphinda benze iiseli zengqondo.

Kwisifundo esiquka abantu abangama-41 abasempilweni kodwa abalupheleyo, i-PQQ elawulwa nge-20 mg / ngosuku kwiiveki ezili-12 yafunyanwa ukuthintela ukuncitshiswa kwengqondo, ngakumbi ngakumbi ekuqwalaseleni nasekubambeni inkumbulo.

I-prinone ye-Pyrroloquinoline inokunceda ukukhusela ukulimala kwengqondo.

Ngo-2012, uphononongo lwamagundwane anikwa i-pqq kwiintsuku ezi-3 ngaphambi kokuba wenzakale ngokwenzakala kwengqondo wafumanisa ukuba umongezo wakwazi ukukhusela iiseli zengqondo ngokulimala.

iv. I-PQQ iphucula ukulala

I-Pyrroloquinoline quinone (PQQ) inceda ekuphuculeni umgangatho wakho wokulala ngokunciphisa ixesha olithathileyo ukuba ulale, inyusa ixesha lokulala kwaye iphucula umgangatho wokulala ngokubanzi.

I-prinone ye-Pyrroloquinoline inokuthi yehlise inani lexinzelelo loxinzelelo (i-cortisol) ngaphakathi kwabantu kwaye ke oko kuphucula ukulala kwabo.

Kwisifundo sabantu abadala abayi-17, i-PQQ enikezwe nge-20 mg / ngosuku kwiiveki ezisi-8 yafunyanwa ukuphucula umgangatho wokulala ngokubhekiselele kwixesha elongezelelekileyo lokulala kunye nelokulala kancinci.

I-PQQ iphucula ukulala

v. Ukuphucula impilo yentliziyo

Amandla e-pyrroloquinoline quinone ukulawula amanqanaba e-cholesterol ayenza inciphise umngcipheko wesifo sentliziyo njengokubetha.

Kuphononongo lwabantu abadala abangama-29, ukongezelelwa kwe-pqq kunciphisa kakhulu amanqanaba amabi e-cholesterol ye-LDL.

I-Pyrroloquinoline quinone iphinda inciphise amanqanaba e-triglycerides akhokelela ekusebenzeni okuphuculiweyo kwe-mitochondrial. Kuphononongo kunye neegundane, i-ppq enikiweyo yafunyanwa ukubahlisa amanqanaba e-triglyceride.

Isongezelelo se-Pqq sinokunceda ukukhusela okanye ukuguqula i-atherosulinosis (ukubetha). Olunye uphononongo lubonise ukuba i-ppq inokuthoba i-C-protein esebenzayo kunye ne-trimethylamine-N-oxide ezizimpawu eziphambili zolu phazamiso.

vi. Ummeli onokubakho ixesha elide

I-Pyrroloquinoline quinone ithathwa njengento engakhuli yevithamini kwaye ke inokunceda ukukhuthaza ukukhula kwakho kunye nophuhliso.

Umsebenzi we-Pyrroloquinoline quinone ekulweni nosulelo, ukuthintela uxinzelelo lwe-oxidative kunye nokuxhasa umsebenzi we-mitochondrial kungqina amandla ayo ekwandiseni ubomi bomntu.

I-PQQ ikwangqinwe ukuba isebenze ukuze kusebenze iindlela zokubonisa iiseli eziguqula umva ukwaluphala kweselula.

Iziphumo ezihambelanayo ezivela kwezi nkqubo zenza ukuba i-PQQ ikhusele ekuguga kweeselfini kwaye ikhuthaze nobomi obude.

Kwimodeli yezilwanyana, ukongezwa nge-pqq kwafunyanwa ukunciphisa uxinzelelo lwe-oxidative kunye nokwandisa ixesha lobomi be-circworms.

vii. Ukukhuselwa kuxinzelelo lwe-oxidative

I-PQQ ibophelela kwiiproteni kungoko kuthintela i-oxidation kwiiseli. Iyakwazi nokukhupha i-radicals yasimahla emzimbeni.

Kwisifundo sesilwanyana, ukuxhaswa kwe-pqq kwafunyanwa ukukhusela ukufa kweseli ye-oxon.

Olunye uphando olwenziweyo in vitro uxele ukuba i-PQQ ikhusele iiseli ze-mitochondria zesisele ezizimeleyo kumonakalo emva koxinzelelo lwe-oxidative kwaye zisuse i-raderoxide radicals.

Uphando olongezelelekileyo ngeempuku zeeswekile ezineswekile (i-STZ) yesifo seswekile, i-PQQ enikezwe kwi-20 mg / kg yomzimba ngeentsuku ezili-15 kwafunyanwa ukunciphisa i-serum ye-glucose kunye neemveliso ze-lipid peroxidation, kunye nokuphakamisa imisebenzi ye-antioxidants kwingqondo yeeswekile yegundane. .

Ezinye i-pyrroloquinoline quinone zisebenzisa kwaye izibonelelo zibandakanya:

Ukuthintela ukutyeba kakhulu

Ukuphucula amajoni omzimba

Ukuphucula ukuchuma

Ikhuthaza ukusebenza kwengqondo nememori

Unceda ukulwa nokukhathala

Kwimeko yangoku yehlabathi, iindaba ezimbi ngenxa ye-COVID 19 ziyeza ngalo lonke ixesha. Ukulwa kwe-Pyrroloquinoline quinone coronavirus kunokusetyenziswa. Esi songezelelo esonwabisayo siyakwandisa ukungakhuseleki kwakho kunye nokubonelela ngoncedo lokulala ukukhulula uxinzelelo.

Ipinroloquinoline quinone isebenzisa

Zeziphi iziphumo ebezingalindelekanga ze-pyrroloquinoline quinone (pqq)?

Xa ufumana i-PQQ kwimithombo yokutya akukho miphumo mibi ilindelweyo ngaphandle kokuba umntu angadibani nokutya okuthile.

Kwizifundo zezilwanyana ezinegundane, isifo sezintso sinento yokwenza nokunxulumana ne-PQQ. Kwisifundo esinye esiquka iigundane, i-PQQ yalimala kwi-11-12 mg / kg ubunzima bomzimba kuxelwe ukuba ibange ukuvuvukala kwezintso.

Kolunye uphononongo lwamagundane, i-PQQ kwi-20 mg / kg bodyweight yafunyanwa ibangela ubuthi kulusu kunye nethambo le-hepatic.

Ukusweleka kwamagayethi kuye kwaxelwa nangemithamo ephezulu malunga ne-500 mg.

Kubantu, akukho miphumo mibi ye-pyrroloquinoline quinone iye yanikwa ingxelo ngamayeza afikelela kwi-20 mg / ngosuku.

Nangona kunjalo, kwiimeko ezinqabileyo, ezinye iziphumo ezinokubakho ze-pyrroloquinoline quinone zinokwenzeka ngenxa yokuthatha ii-overdoses. Iziphumo ebezingalindelekanga zibandakanya ukuqaqanjelwa yintloko, ukudinwa, ukudakumba, ukuthoba ngamandla kunye nokuqaqamba.

Umthamo we-PQQ

Kuba i-pyrroloquinoline quinone (pqq) ayikavunywa ngokupheleleyo yi-Federal Drug Administration ekusebenziseni amayeza, akukho dosage yomgangatho wepinroloquinoline we-quinone usethe, nangona ezinye izifundo zifumene ukuba iipilisi ze-pinroloquinoline quinone ukusuka kwi-2 mg / ngosuku ziluncedo. Nangona kunjalo, uninzi lwezongezelelo ze-PQQ zikwidosi ezingama-20 ukuya kuma-40 mg.

Iprosroloquinoline quinone dosage ingahluka ngokwenjongo ebekiweyo. Olunye uphononongo lubonisa ukuba umthamo we-0.075 ukuya kwi-0.3 mg / kg ngosuku usebenza kakuhle ekuphuculeni umsebenzi we-mitochondria, ngelixa idosi ephezulu malunga ne-20 mg ngosuku inokuba yimfuneko ukulwa nokuvuvukala.

Xa kuthathwa kunye ne-COQ10, iidosi ezingama-20 mg PQQ kunye ne-200 mg COQ10 ziyacetyiswa, nangona ezinye izifundo zisebenzisa i-20 mg ye-PQQ kunye ne-300 mg COQ10 ingakhange ichaze naziphi na iziphumo ezibi.

Isongezelelo se-PQQ kufuneka sithathwe ngomlomo kwaye ngokukhethekileyo ngaphambi kokutya-kwisisu esingenanto.

Uyacetyiswa kakhulu ukuba uqale kwiidosi ezisezantsi kwaye unyuke njengoko kufuneka.

Kwaye kubalulekile ukuba uqaphele ukuba uninzi lwezifundo alukhuthazi ukuthatha idosi ngaphaya kwe-80 mg ngosuku.

Kukutya ntoni okuqukethe i-pyrroloquinoline quinone (pqq)?

IPyrroloquinoline quinone (pqq) ifumaneka ngokutya okuninzi kwesityalo, nangona zihlala zisezantsi kakhulu. Izityalo zifumana i-PQQ ngqo kumhlaba nakwintsholongwane yomhlaba njenge-methylotrophic, rhizobium, kunye neebhaktiriya ze-acetobacter.

I-Pqq kwizicubu zomntu iza ngokuyinxenye ekutyeni kwaye ngokuyinxenye kwimveliso yeebacteria ezifakwe ngaphakathi.

Inqanaba le-pyrroloquinoline quinine kwezi ndawo zokutya zahluka kakhulu ukusuka kwi-0.19 ukuya kwi-61ng / g. Nangona kunjalo, i-pqq igxile ngakumbi koku kukutya okulandelayo:

Ukutya kwe-Pqq

Eminye imithombo yokutya ye-PQQ ibandakanya amahlumela e-broccoli, i-mustard yentsimi, iimbotyi ze-fava, iiapile, amaqanda, isonka, iwayini kunye nobisi.

Ngenxa yamanqanaba asezantsi e-pqq kukutya okuninzi, kuya kuba nzima ukufumana isixa esaneleyo sokuxhuma izibonelelo ezinxulumene ne-pqq ngaphandle kokuba sithathe inani elikhulu kakhulu lokutya okuthile. Oku ke kunyanzelisa ukuba umntu athenge i-pqq isongezelelo sokuxhasa ukutya okufanelekileyo.

I-PQQ kunye ne-COQ10

I-coenzyme Q10 (COQ10) ihlala ithathwa njenge-mitochondria enhancer yenzeka emzimbeni womntu nakokutya okuninzi. Iyafana ne-PQQ; Nangona kunjalo, i-pyrroloquinoline quinine kunye ne-CQ10 isebenza ngeendlela ezahlukileyo kakhulu okanye zisebenzisa iindlela ezahlukeneyo zokuphucula imisebenzi ye-mitochondrial.

I-coenzyme Q10 yi-cofactor ebalulekileyo esebenza ngaphakathi kwe-mitochondria kwaye idlala indima ebalulekileyo ekuphefumleni kweselula kunye nokusetyenziswa kweoksijini kwimveliso yamandla. I-PQQ kwelinye icala inyusa inani leeseli ze-mitochondria kunye nokuphucula ukusebenza kwe-mitochondria.

Xa uthathwa kunye, i-pyrroloquinoline quinine kunye ne-CQ10, inika iziphumo ezihambelana kunye nokuphucula ukusebenza kwe-mitochondrial, ukusikhusela kuxinzelelo lwe-oxidative kunye nokulawula iindlela zokungena kweselula.

Thenga isongezelelo se-PQQ

Kukho izibonelelo ezininzi ezingenakulinganiswa ze-pqq supplement powder kwaye kuya kufuneka uthathele ingqalelo ukuxabisa ukutya kwakho ngayo. I-powder ye-PQQ yentengiso ifumaneka ngokulula kwi-intanethi. Nangona kunjalo, kwiziphumo ezilungileyo kakhulu hlala ngakumbi xa uthenga i-pqq eyongezelelweyo ukuqinisekisa ukuba ufumana umgangatho osemgangathweni.

Ukuba ucinga ukuthenga i-pqq bulk powkqinisekisa ukuba uyayifumana kubathengisi abanokuthenjwa.

Ucaphulo

  1. UChowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). I-Pyrroloquinoline quinone ivuselela i-biogenesis ye-mitochondrial ngokusebenzisa impendulo ye-cAMP-yokubopha i-phosphorylation yeproteination kunye nokunyusa ukubonakaliswa kwe-PGC-1α. Ibhayol. Imichiza. 285: 142–152.
  2. Harris CB1, Chowanadisai W, Mishchuk YENZA, Satre MA, ISlupsky CM, Rucker RB. (2013). I-dietary pyrroloquinoline quinone (PQQ) iimpawu ezibonisa ukuvuvukala kunye ne-metabolism enxulumene ne-metabolism kwizifundo zabantu. J Nutr Biochem.NgoDisemba; 24 (12): 2076-84. I-Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., noSuzuki O. (1995). Amanqanaba e-pyrroloquinoline quinone kukutya ezahlukeneyo. J.307: 331-333.
  4. UNunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). I-Pyrroloquinoline quinone ithintela ukufa kwe-oxidative ye-neuronal nokufa mhlawumbi ngokutshintsha kwesimo se-oxidative ye-DJ-1. Ikhemisi. Bull. 31: 1321–1326.
  5. UPaul Hwang kunye noDarryn S. Willoughby (ngo-2018). Iindlela ezingemva kwePyrroloquinoline Quinone Supplement kwiSkeletal Muscle Mitochondrial Biogenesis: Iziphumo ezinokubakho zeSynergistic ngokuzivocavoca, iJenali yeKholeji yaseMelika yoKondla, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Izibalo T, iSiphepho D, kunye noBauerly K, et al. (2006). Isicatshulwa esipheleleyo: I-Pyrroloquinoline quinone modulates ubungakanani be-mitochondrial kunye nokusebenza kweempuku. J Nutriti. Feb; 136 (2): 390-6.
  7. UZhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). Isiphumo se-neuroprotective ye-pyrroloquinoline quinone ekulimaleni konzakala kwengqondo. J Neurotrauma. Mar 20; 29 (5): 851-64.

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